Actively Recruiting
Study Comparing Two Different Schedules of Radiation for Early-stage Lung Cancer
Led by University of Rochester · Updated on 2025-04-24
100
Participants Needed
1
Research Sites
413 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study's goal is to find out if the kind of side effects people experience from radiation is different depending on the schedule of their radiation treatment. Patients will be randomly assigned to either the 3 Fraction or 5 Fraction schedule of radiation. After patients complete radiation treatment, they will follow up with their radiation oncologist.
CONDITIONS
Official Title
Study Comparing Two Different Schedules of Radiation for Early-stage Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological confirmation not required, but eligible non-small cell lung cancers include squamous cell carcinoma, adenocarcinoma, large cell carcinoma, bronchioalveolar cell carcinoma, or unspecified non-small cell carcinoma
- Diagnosed with AJCC stage I or II lung cancer with one of the following TNM stages: T1, N0, M0 or T2 (≤ 5 cm), N0, M0
- Patients with hilar or mediastinal lymph nodes ≤ 1 cm and no abnormal uptake on PET are considered N0
- Patients with suspicious lymph nodes must have negative biopsies for cancer
- Zubrod performance status 0-2 within 4 weeks before study entry
- Women of childbearing potential and men must use effective contraception
- Required evaluations within specified timeframes before study entry: history and physical by radiation oncologist, vital signs, thoracic surgeon evaluation, pulmonary function tests, CT chest scan including lungs and mediastinum, whole-body PET scan
- Signed informed consent
You will not qualify if you...
- Central tumors located within 2 cm of the proximal bronchial tree
- Evidence of regional or distant metastases
- Synchronous primary non-small cell lung cancer
- Prior malignancy within the past 2 years except non-melanomatous skin cancer, in situ cancer, or thyroid cancer
- Previous lung or mediastinal radiotherapy
- Plans to receive other antineoplastic therapies concurrently
- Active systemic, pulmonary, or pericardial infection
- Pregnant or lactating women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
D
Deepinder Singh, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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