Actively Recruiting
Study of Contrast - Induced Nephropathy After Intravenous Contrast Procedures at Sohag University Hospitals
Led by Sohag University · Updated on 2025-05-14
200
Participants Needed
2
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Contrast-induced nephropathy (CIN) is a serious complication of angiographic procedures and results from administration of iodinated contrast media (CM). CIN is the third most common cause of hospital acquired acute renal injury representing about 12% of the cases. The reported incidence of CIN varies widely across the literature, depending on the patient population studied and the baseline risk factors . An overall incidence of CIN following intraarterial contrast injection in the general population was reported to be 0.6-2.3%. Although the incidence of CIN is low in patients with normal renal function, its prevalence can be much higher in several patient subsets e.g. diabetics, patients with existing renal insufficiency. Contrast-induced nephropathy is defined as a rise in serum creatinine of at least 0.5 mg/dL or a 25% increase from baseline within 48 to 72 hours after contrast exposure. The Kidney Disease Improving Global Outcome (KDIGO) definition is different, with stage 1 being a rapid rise of creatinine to greater than 0.3 mg/dL within 48 hours or the relative rise of 50% or more from baseline in 7 days or less or a reduction in urine output to less than 0.5 ml/kg/hr for 6 to 12 hours. This severity is further staged based on creatinine levels, urine output, or the need for renal replacement therapy. In most cases of CIN there is an asymptomatic, non-oliguric rise of serum creatinine within 24hours; however, in more severe cases, the creatinine concentration may not peak until 5-10 days and the increase may be associated with oliguria, It may occasionally progress to end-stage renal failure. The incidence of CIN varies widely among the publications in the literature and studies. In this study, we will evaluate the incidence of CIN amongst patients receiving intravenous contrast in sohag university hospital, to study the variations in serum creatinine levels with contrast administration.
CONDITIONS
Official Title
Study of Contrast - Induced Nephropathy After Intravenous Contrast Procedures at Sohag University Hospitals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Inpatients and outpatients aged 18 years and above who underwent a single intravenous contrast procedure
You will not qualify if you...
- Patients below 18 years or unable to provide consent
- Patients with end-stage renal disease or on maintenance hemodialysis
- Patients with New York Heart Association class IV congestive cardiac failure or cardiogenic shock
- History of hypersensitivity to contrast or exposure to contrast in the last 24-48 hours
- Nursing or pregnant subjects
- Patients with malignancy or other organ failure such as decompensated liver cirrhosis
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sohag university hospitals
Sohag, Egypt
Actively Recruiting
2
Sohag university hospitals
Sohag, Egypt
Actively Recruiting
Research Team
E
Esraa R Youssef, Resident
CONTACT
U
Usama A Arafa, professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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