Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT06993597

Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

Led by University of Maryland, Baltimore · Updated on 2025-09-09

60

Participants Needed

1

Research Sites

39 weeks

Total Duration

On this page

Sponsors

U

University of Maryland, Baltimore

Lead Sponsor

N

National Eye Institute (NEI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.

CONDITIONS

Official Title

Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Diagnosis of primary open angle glaucoma (POAG) or no history of glaucoma (for controls)
  • Open angle on gonioscopy (Shaffer grade 3 or 4)
  • Best-corrected visual acuity of 20/25 or better
  • Refractive error between +3.00 and -5.00 diopters
  • No prior use of topical glaucoma medications
  • Diagnosis of High Tension Glaucoma (IOP 65 22 mmHg on 3 visits)
  • Diagnosis of Normal Tension Glaucoma (IOP 64 21 mmHg on 3 visits)
  • Age-matched control with normal optic nerve and visual fields
Not Eligible

You will not qualify if you...

  • Corneal abnormalities or conditions interfering with Brillouin or applanation tonometry
  • Retinal diseases affecting RNFL (e.g., macular traction)
  • History of ocular surgery or laser
  • Diagnosis of diabetes
  • History of uveitis
  • History of prolonged steroid use
  • Neurodegenerative or systemic diseases (e.g., multiple sclerosis, Alzheimer's, Parkinson's, schizophrenia)
  • Unreliable visual fields
  • Contraindications to beta blockers (e.g., bradycardia, severe pulmonary disease)
  • Moderate to severe glaucoma (per Hodapp-Anderson-Parrish criteria)
  • History of contact lens use
  • Low blood pressure

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Maryland School of Medicine

Baltimore, Maryland, United States, 21201-1757

Actively Recruiting

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Research Team

O

Osamah Saeedi, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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