Actively Recruiting
A Prospective Cohort Study on the Correlation Between Cotinine Levels and Intracranial Unruptured Aneurysm Wall Enhancement Using High-resolution MRI
Led by Zhujiang Hospital · Updated on 2025-07-18
450
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with unruptured intracranial aneurysms to understand the relationship between cotinine levels and aneurysm wall enhancement seen on high-resolution magnetic resonance imaging (HRMRI). This observational study aims to explore how these imaging features and cotinine levels might relate to the risk of aneurysm rupture and patient outcomes. The research includes following patients' prognosis and aneurysm occlusion rates to better understand this connection. Participants undergo high-resolution magnetic resonance angiography to detect and classify the presence or absence of aneurysm wall enhancement. Blood or urine samples are collected for cotinine testing, which relates to smoking exposure. Patients are grouped based on whether their aneurysm wall shows enhancement on HRMRI. The study follows patients for at least one year to observe imaging features, functional outcomes measured by the modified Rankin Scale (mRS), and aneurysm occlusion rates. During the study, participants will have imaging and clinical assessments at baseline and follow-up visits according to the research protocol. Researchers will monitor aneurysm features on HRMRI, patient functional status at 12 months, and aneurysm occlusion status after treatment. Participants will also provide samples for cotinine analysis. The study is expected to last until March 2027, with ongoing follow-up to evaluate correlations between imaging findings, cotinine levels, and patient outcomes.
CONDITIONS
Brief Title
A Study on the Correlation Between Cotinine Levels and Aneurysm Wall Enhancement on HRMRI.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years old, male or infertile female
- Diagnosed with intracranial aneurysm by CTA, MRA, or DSA and suitable for endovascular treatment
- Fully understand the study purpose and voluntarily sign informed consent
- Willing to undergo high-resolution magnetic resonance imaging
- Willing to follow up and participate according to the study protocol
You will not qualify if you...
- Aneurysms related to arteriovenous malformation, Moyamoya disease, or dural arteriovenous fistula
- Contraindications for high-resolution magnetic resonance imaging
- Participation in other drug or medical device clinical trials
- Severe underlying diseases or poor clinical condition preventing surgery
- Poor compliance or inability to cooperate with follow-up
- History of severe allergy to contrast agents
- Life expectancy less than 2 years
- Women who are breastfeeding or planning pregnancy during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 day
Participants undergo high-resolution magnetic resonance imaging and cotinine testing to assess aneurysm wall enhancement and cotinine levels.
1 visit (in-person)
Duration - 1 year
Participants are followed up for imaging features, prognostic scores, and aneurysm occlusion rate over one year.
Follow-up visits as scheduled over 1 year
Trial Site Locations
Total: 1 location
1
Zhujiang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 528400
Actively Recruiting
Research Team
X
Xin Feng, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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