What is this study trying to find out about intracranial aneurysms?

This study is investigating the relationship between cotinine levels, which indicate smoking exposure, and the enhancement of the aneurysm wall seen on high-resolution MRI in patients with unruptured intracranial aneurysms. Researchers aim to understand how these factors might relate to the risk of aneurysm rupture and patient outcomes. The study is led by Zhujiang Hospital.

Who may be eligible for this intracranial aneurysm clinical trial?

Adults aged 18 to 75 years with a diagnosis of unruptured intracranial aneurysm who are willing to undergo high-resolution MRI and participate in follow-up may be eligible. Both males and infertile females can join. People with certain vascular conditions, severe illnesses, or MRI contraindications may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this intracranial aneurysm clinical trial?

Study-related care, including imaging, cotinine testing, and all trial visits, is provided at no cost. Personal travel and other expenses may vary and are typically not covered by the study. Participants should plan accordingly.

Actively Recruiting

Age: 18Years - 75Years

All Genders

Healthy Volunteers

ID06447714

Study of Cotinine Levels and Intracranial Aneurysm Wall Enhancement Using High-Resolution MRI in Adults Aged 18 to 75

Led by Zhujiang Hospital · Updated on 2025-07-18

450

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying patients with unruptured intracranial aneurysms to understand the relationship between cotinine levels and aneurysm wall enhancement seen on high-resolution magnetic resonance imaging HRMRI. This observational study aims to explore how these imaging features and cotinine levels might relate to the risk of aneurysm rupture and patient outcomes. The research includes following patients prognosis and aneurysm occlusion rates to better understand this connection. Participants undergo high-resolution magnetic resonance angiography to detect and classify the presence or absence of aneurysm wall enhancement. Blood or urine samples are collected for cotinine testing, which relates to smoking exposure. Patients are grouped based on whether their aneurysm wall shows enhancement on HRMRI. The study follows patients for at least one year to observe imaging features, functional outcomes measured by the modified Rankin Scale mRS, and aneurysm occlusion rates. During the study, participants will have imaging and clinical assessments at baseline and follow-up visits according to the research protocol. Researchers will monitor aneurysm features on HRMRI, patient functional status at 12 months, and aneurysm occlusion status after treatment. Participants will also provide samples for cotinine analysis. The study is expected to last until March 2027, with ongoing follow-up to evaluate correlations between imaging findings, cotinine levels, and patient outcomes.

CONDITIONS

Brief Title

A Study on the Correlation Between Cotinine Levels and Aneurysm Wall Enhancement on HRMRI.

Who Can Participate

Age: 18Years - 75Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age 18 to 75 years old, male or infertile female
Diagnosed with intracranial aneurysm by CTA, MRA, or DSA and suitable for endovascular treatment
Fully understand the study purpose and voluntarily sign informed consent
Willing to undergo high-resolution magnetic resonance imaging
Willing to follow up and participate according to the study protocol

You will not qualify if you...

Aneurysms related to arteriovenous malformation, Moyamoya disease, or dural arteriovenous fistula
Contraindications for high-resolution magnetic resonance imaging
Participation in other drug or medical device clinical trials
Severe underlying diseases or poor clinical condition preventing surgery
Poor compliance or inability to cooperate with follow-up
History of severe allergy to contrast agents
Life expectancy less than 2 years
Women who are breastfeeding or planning pregnancy during the study period

Research Team

Xin Feng, MD

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