Actively Recruiting
Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes
Led by The Second Affiliated Hospital of Kunming Medical University · Updated on 2025-06-11
717
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with brain injuries caused by various reasons often need tracheotomy to improve breathing, but this procedure can cause the air to lose its nasal regulation, increase the risk of lung infections, and reduce their quality of life. Tracheal extubation is crucial for patient recovery. Environmental factors in high-altitude areas have a significant impact on human cardiovascular function, including changes in blood oxygen caused by low oxygen environments and cardiovascular adaptability of long-term residents. There is limited research on the impact of high altitude on the success rate of tracheal extubation in brain injury. The research team conducted a retrospective study on 501 patients who underwent tracheotomy at the Second Affiliated Hospital of Kunming Medical University and found that high GCS scores and hemoglobin concentrations were beneficial for extubation. The increase in hemoglobin concentration among high-altitude residents may be an adaptive response to hypoxia, and the research team speculates that this may become a protective factor for successful extubation. However, some argue that altitude sickness and adaptive genetic changes may counteract each other. Simonson's team found that the decline of hemoglobin concentration in Tibetans was related to specific gene expression, indicating that the genetic adaptability of high altitude residents had a unique relationship with hemoglobin concentration. Therefore, the research team speculates that people living in highlands for a long time are more adaptable to hypoxic environments than those living in lowlands. Under severe stress (hypoxia), people living in highlands for a long time may have lower sensitivity to pulmonary blood flow redistribution or oxygen delivery compared to those living in lowlands. This study is a multicenter observational study, with sub centers listed as follows: Jiangchuan District People's Hospital, Huaning County People's Hospital, Baoshan Second People's Hospital, Huize County People's Hospital, Mengla County People's Hospital, Tonghai County People's Hospital, Jinghong City First People's Hospital, Xuanwei City First People's Hospital, Qiubei County People's Hospital, Fengqing County People's Hospital, Weixin County People's Hospital, Yulong County People's Hospital, Yanshan County People's Hospital, Xundian County People's Hospital, Shizong County People's Hospital, Luxi County People's Hospital, Yunnan Province Northeast Yunnan Central Hospital, Luoping County People's Hospital, Xinping County General Hospital, Suijiang County People's Hospital, Nanhua County Hospital, Guangnan County People's Hospital County People's Hospital, Jianshui County People's Hospital, Simao District People's Hospital of Pu'er City, Funing County People's Hospital, Xinping County Traditional Chinese Medicine Hospital Xundian County First People's Hospital and Jingdong County People's Hospital.
CONDITIONS
Official Title
Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Hospitalized in rehabilitation with acute non-traumatic ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage requiring tracheostomy
- Stable vital signs: systolic blood pressure 90-160 mmHg, diastolic 60-100 mmHg, respiratory rate 12-30 breaths/min, heart rate 60-120 beats/min, body temperature 36.5°C-38.5°C, arterial oxygen saturation above 90%
- Glasgow Coma Scale score between 5 and 15
- Tracheostomy performed within 24 to 72 hours after stroke onset
- Peripheral blood hemoglobin concentration at admission within 120-180 g/L for males and 110-160 g/L for females
- Signed informed consent from patient or legal guardian
You will not qualify if you...
- History of severe cardiopulmonary diseases with New York Heart Association class III or IV, or recent acute myocardial infarction or unstable angina within 6 months
- Advanced cancer with life expectancy less than 6 months or ongoing chemotherapy, radiotherapy, or palliative care
- Severe liver or kidney failure such as decompensated cirrhosis or long-term dialysis
- Uncontrolled endocrine disorders like thyrotoxic crisis, myxedema coma, diabetic ketoacidosis, or hyperosmolar hyperglycemic state
- Blood clotting disorders including congenital or acquired coagulopathies or active anticoagulation therapy not correctable within 72 hours
- Major surgery within the past 3 months
- Severe chest or abdominal trauma within 1 month before stroke with incomplete recovery
- Active uncontrolled infection at admission with fever over 38.5°C lasting more than 24 hours, elevated white blood cells, or positive bacterial cultures
- Recent exposure to infectious diseases within 1 week with suspected infection
- History of neurodegenerative or motor neuron diseases
- Congenital neurological developmental disorders
- Severe uncontrolled psychiatric disorders affecting daily life or treatment adherence
- Cognitive impairment with Mini-Mental State Examination score below 10
- Pregnancy or breastfeeding
- Allergies or contraindications to study drugs or procedures
- Unable to complete follow-up or required tests
- Non-compliance with study protocol
- Lack of informed consent
- Participation in other interventional clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Electroencephalography
Kunming, Yunnan, China
Actively Recruiting
Research Team
L
liqing Yao
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here