Actively Recruiting
Evaluating The Role Of Corticosteroids In Post-Ureteroscopy Recovery For Urinary Calculi
Led by Mayo Clinic · Updated on 2026-02-03
90
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research is focused on adults aged 18 years and older who have kidney or ureteral stones and are undergoing ureteroscopy with stent placement. The study aims to find out whether adding the corticosteroid prednisone to the usual pain medications after surgery can help reduce postoperative pain. It is a Phase 4 trial sponsored by Mayo Clinic, involving people of all genders and ethnic backgrounds. Participants are randomly assigned to one of two groups. One group receives the standard postoperative ureteroscopy medication plus prednisone 25 mg taken orally once daily for five days after surgery. The other group receives the same standard care plus a placebo pill with the same schedule. This triple-blind study compares the effects of prednisone versus placebo in managing post-surgical pain. During the study, pain levels will be measured using the Visual Analog Scale at baseline and on days 1, 2, and 3 after surgery. Researchers will also track the use and amount of non-opioid pain medications over three days, as well as changes in quality of life and stent symptom scores. The study includes careful monitoring of participant adherence and safety throughout the postoperative period, with total participation spanning at least the first three days after surgery.
CONDITIONS
Brief Title
A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with kidney or ureteral stones confirmed by imaging and choosing ureteroscopy with stent placement
- Age 18 years or older
- Patients of any gender
- Patients of all ethnic backgrounds
- Able to give informed consent
- Willing and able to follow study requirements
You will not qualify if you...
- History of chronic pain
- Chronic use of opioids or other pain medications for more than 12 weeks
- Known allergy to corticosteroids
- Known or suspected pregnancy
- Unable to give informed consent or meet study requirements
- Undergoing bilateral ureteroscopy
- Current use of corticosteroids
- Insulin-dependent diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 days
Participants receive standard postoperative ureteroscopy medication plus either prednisone 25 mg or a placebo pill orally once a day for 5 days post-surgery.
1 baseline visit and 3 follow-up visits during the first 3 days post-surgery
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
Research Team
R
Rev V. Vilasan Shylaja
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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