Study of Prednisone to Reduce Pain After Ureteroscopy for Kidney or Ureteral Stones

What this Trial Is About

This research is focused on adults aged 18 years and older who have kidney or ureteral stones and are undergoing ureteroscopy with stent placement. The study aims to find out whether adding the corticosteroid prednisone to the usual pain medications after surgery can help reduce postoperative pain. It is a Phase 4 trial sponsored by Mayo Clinic, involving people of all genders and ethnic backgrounds. Participants are randomly assigned to one of two groups. One group receives the standard postoperative ureteroscopy medication plus prednisone 25 mg taken orally once daily for five days after surgery. The other group receives the same standard care plus a placebo pill with the same schedule. This triple-blind study compares the effects of prednisone versus placebo in managing post-surgical pain. During the study, pain levels will be measured using the Visual Analog Scale at baseline and on days 1, 2, and 3 after surgery. Researchers will also track the use and amount of non-opioid pain medications over three days, as well as changes in quality of life and stent symptom scores. The study includes careful monitoring of participant adherence and safety throughout the postoperative period, with total participation spanning at least the first three days after surgery.

A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi