Actively Recruiting
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Led by Corxel Pharmaceuticals · Updated on 2026-04-17
240
Participants Needed
46
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady dose of an SGLT2 inhibitor, for at least 90 days. The study is being done at multiple medical centers. Participants are assigned by chance (randomized) to different groups, and neither the participants nor the study staff know which group they're in (double-blind). The groups are compared side by side (parallel), and some participants will receive inactive pills (placebo) to help measure the true effect of the study drug. After screening, participants will be randomly placed into one of six groups, with equal chances of being in any group. Each group will receive a different dose of CX11 or a placebo. Treatment will last 24 weeks. After that, all participants will have a 2-week follow-up period to check on safety.
CONDITIONS
Official Title
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75
- Diagnosis of type 2 diabetes for at least 6 months
- HbA1c between 7.0% and 10.5%
- Body mass index between 23 and 50 kg/m²
- Stable body weight for the past 3 months
- Stable dose of metformin (≥1000 mg/day) with or without SGLT2 inhibitor for at least 3 months
- Women of childbearing potential must use highly effective contraception for at least 6 months before screening, during the study, and for 90 days after last dose
- Negative pregnancy test within 24 hours before first dose
- Agreement to avoid grapefruit and grapefruit products
You will not qualify if you...
- Planned start or change of medications affecting weight or glucose metabolism for more than 14 days
- Type 1 diabetes or history of diabetic ketoacidosis
- Use of GLP-1 receptor agonists within past 6 months or any prior exposure to CX11
- Use of insulin for blood sugar control within past 12 months
- More than one episode of severe low blood sugar with awareness
- Cardiovascular or cerebrovascular events within past 6 months including heart attack, bypass surgery, valve disease, unstable angina, stroke, or decompensated heart failure
- Abnormal ECG indicating safety risk
- Poorly controlled hypertension (systolic ≥180 mmHg or diastolic ≥100 mmHg)
- Acute or chronic pancreatitis or symptomatic gallbladder disease
- Abnormal or unstable thyroid function or relevant family history
- Cancer within past 5 years except certain low-risk skin or prostate cancers
- Gastrointestinal conditions affecting drug absorption or major GI surgery
- Active liver disease other than nonalcoholic fatty liver
- Uncontrolled diabetic eye diseases
- Abnormal lab results at screening including kidney function, liver enzymes, bilirubin, amylase, lipase, triglycerides, thyroid tests, calcitonin, or low hemoglobin levels
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 46 locations
1
Central Research Associates - Flourish - PPDS
Birmingham, Alabama, United States, 35205-1605
Actively Recruiting
2
AES - DRS - Synexus Clinical Research US, Inc. - Birmingham
Birmingham, Alabama, United States, 35211-1320
Actively Recruiting
3
AES - DRS - Optimal Research Alabama - Huntsville
Huntsville, Alabama, United States, 35802-2569
Actively Recruiting
4
Ark Clinical Research - Long Beach
Long Beach, California, United States, 90815-2521
Actively Recruiting
5
Flourish Research - Walnut Creek - PPDS
Walnut Creek, California, United States, 94598-3343
Actively Recruiting
6
AES - DRS - Optimal Research Florida - Melbourne
Melbourne, Florida, United States, 32934-8172
Actively Recruiting
7
Tampa General Hospital
Tampa, Florida, United States, 33606-3571
Actively Recruiting
8
Conquest Research LLC - Winter Park
Winter Park, Florida, United States, 32789-1857
Actively Recruiting
9
Privia Medical Group Georgia, LLC - Albany - Javara - PPDS
Albany, Georgia, United States, 31707-0205
Actively Recruiting
10
Javara Inc. - Fayetteville
Fayetteville, Georgia, United States, 30214
Not Yet Recruiting
11
Privia Medical Group Georgia, LLC - Savannah - Javara - PPDS
Savannah, Georgia, United States, 31406-3928
Actively Recruiting
12
Privia Medical Group Georgia, LLC - Thomasville - Javara - PPDS
Thomasville, Georgia, United States, 31792-6618
Actively Recruiting
13
AES - DRS - Synexus Clinical Research US, Inc. - Chicago
Chicago, Illinois, United States, 60602-3960
Actively Recruiting
14
AES - DRS - Synexus Clinical Research US, Inc. - Evansville
Evansville, Indiana, United States, 47714-7513
Actively Recruiting
15
Privia Medical Group, LLC - Kelly's Collaborative Care - Javara - PPDS
Silver Spring, Maryland, United States, 20901-1586
Actively Recruiting
16
Elixia Health - Springfield - Elixia - PPDS
Springfield, Massachusetts, United States, 01103
Actively Recruiting
17
Elixia Health - Michigan Kidney Consultants, LLC - Elixia - PPDS
Pontiac, Michigan, United States, 48341
Actively Recruiting
18
AES - DRS - Synexus Clinical Research US, Inc. - Edina - Minneapolis
Edina, Minnesota, United States, 55435-4305
Actively Recruiting
19
Mankato Clinic - East Main Street - Javara - PPDS
Mankato, Minnesota, United States, 56001
Actively Recruiting
20
Hassman Research Institute - Berlin - CenExel - PPDS
Berlin, New Jersey, United States, 08009
Actively Recruiting
21
Albuquerque Clinical Trials Inc
Albuquerque, New Mexico, United States, 87102-2619
Actively Recruiting
22
M3 Wake Research, Inc - M3 WR
Raleigh, North Carolina, United States, 27612-8106
Actively Recruiting
23
Unity Clinical Research
Oklahoma City, Oklahoma, United States, 73118-2872
Actively Recruiting
24
Monroe Biomedical Research Charleston
North Charleston, South Carolina, United States, 29406
Actively Recruiting
25
M3 Wake Research - Dallas
Dallas, Texas, United States, 75246
Actively Recruiting
26
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390-7202
Not Yet Recruiting
27
SMS Clinical Research, LLC - 400 W. Kearney St
Mesquite, Texas, United States, 751497
Actively Recruiting
28
AES - DRS - Synexus Clinical Research US, Inc. - San Antonio
San Antonio, Texas, United States, 78229-3272
Actively Recruiting
29
Flourish Research - San Antonio - PPDS
San Antonio, Texas, United States, 78229-3539
Actively Recruiting
30
Privia Medical Group- North Texas - Stephenville - Javara - PPDS
Stephenville, Texas, United States, 76401-1860
Actively Recruiting
31
Conquest Research - Arlington
Arlington, Virginia, United States, 22205
Actively Recruiting
32
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Poznaniu
Poznan, Greater Poland Voivodeship, Poland, 60-702
Not Yet Recruiting
33
Centrum Medyczne Pratia Bydgoszcz - PPDS
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85 001
Not Yet Recruiting
34
Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne
Krakow, Lesser Poland Voivodeship, Poland, 31-261
Not Yet Recruiting
35
FutureMeds - Krakow - PPDS
Krakow, Lesser Poland Voivodeship, Poland, 31-501
Not Yet Recruiting
36
Gabinet Lekarski Robert Witek
Tarnów, Lesser Poland Voivodeship, Poland, 33-100
Not Yet Recruiting
37
METABOLICA Sp. z o.o
Tarnów, Lesser Poland Voivodeship, Poland, 33-100
Not Yet Recruiting
38
AES - DRS - Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
Wroclaw, Lower Silesian Voivodeship, Poland, 50-381
Not Yet Recruiting
39
AES - DRS - Synexus Polska Sp. Z o.o. Oddzial w Lodzi
Lodz, Lódzkie, Poland, 90-127
Not Yet Recruiting
40
FutureMeds - Lodz - PPDS
Lodz, Lódzkie, Poland, 91-363
Not Yet Recruiting
41
FutureMeds - Warszawa Centrum - PPDS
Warsaw, Masovian Voivodeship, Poland, 00-215
Not Yet Recruiting
42
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie
Warsaw, Masovian Voivodeship, Poland, 02-672
Not Yet Recruiting
43
ETG Warszawa - PPDS
Warsaw, Masovian Voivodeship, Poland, 02-677
Not Yet Recruiting
44
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku
Gdansk, Pomeranian Voivodeship, Poland, 80-382
Not Yet Recruiting
45
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdyni
Gdynia, Pomeranian Voivodeship, Poland, 81-537
Not Yet Recruiting
46
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Czestochowie
Częstochowa, Silesian Voivodeship, Poland, 42-202
Not Yet Recruiting
Research Team
S
Study Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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