Actively Recruiting
Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-09-16
280
Participants Needed
9
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if the dose of radiation therapy that is effective in producing a treatment response, delivered over a shorter treatment period, is a safe approach that causes few or mild side effects in women with newly diagnosed breast cancer or DCIS who have had a lumpectomy procedure.
CONDITIONS
Official Title
Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Age 45 years or older
- Unicentric pathological stage I invasive ductal breast cancer or DCIS less than 3 cm confirmed by pathology or mammogram
- Histologically negative tumor margin or no tumor in a re-excision specimen on final shaved specimen
- ECOG Performance Status of 0 or 1
- Negative serum pregnancy test within 14 days before treatment if of child-bearing potential
- Ability to provide written informed consent and comply with study requirements
- Female subjects of childbearing potential willing to use two methods of birth control, be surgically sterile, or abstain from heterosexual activity during study participation
- Intermediate risk substudy includes specific criteria such as post-neoadjuvant chemotherapy status, oncotype RS score 26 or higher, PAM50 ROR high score, presence of lymphovascular invasion, age 40-49 with no history of certain breast conditions or family history, invasive lobular carcinoma, or surgical margins less than 1 mm to invasive or in-situ disease
You will not qualify if you...
- Patients with distant metastasis
- Pregnant or breastfeeding patients
- Patients with diffuse suspicious microcalcifications or known multicentric or multifocal disease
- Prior radiation therapy to the ipsilateral or contralateral breast or thorax
- Histological evidence of extensive lymphovascular invasion
- Histological evidence of extensive intraductal component (EIC)
- Known BRCA1 or BRCA2 mutation carriers
- History of cosmetic or reconstructive breast surgery
- Medical conditions such as uncontrolled infection, uncontrolled diabetes, or connective tissue diseases deemed hazardous
- Currently active second malignancy other than non-melanoma skin cancers
- Enrollment in other adjuvant systemic therapy protocols for breast cancer
- Expecting to conceive during the study period up to 180 days after last treatment
- Concurrent anti-neoplastic treatment during protocol treatment except hormonal or anti-Her2 therapies
- Ongoing therapy with other investigational agents
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Norwalk Hospital
Norwalk, Connecticut, United States, 06850
Actively Recruiting
2
Baptist Alliance Miami Cancer Institute
Miami, Florida, United States, 33143
Actively Recruiting
3
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
4
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
5
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
6
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
7
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Actively Recruiting
8
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10021
Actively Recruiting
9
Memorial Sloan Kettering Nassau
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
A
Atif J Khan, MD
CONTACT
S
Simon Powell, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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