Actively Recruiting
Study on Deep Transcranial Magnetic Stimulation for Enhancing Insight
Led by Shanghai Mental Health Center · Updated on 2025-02-18
138
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Impaired insight is a key factor in the conversion of high-risk individuals to schizophrenia, but there is a lack of targeted interventions. We found that an electroencephalogram (EEG) signal, error-related negativity (ERN), was closely related to impaired insight. The more pronounced the ERN attenuation in patients with high-risk and first-episode psychosis, the more severe the impairement of clinical insight. ERN is a negative potential that appears at the frontal and central scalp electrode locations within 100 ms after an erroneous behavioral response, reflecting the activity of the brain's error-monitoring system. Research has shown that the brain region underlying ERN is partly located in the anterior cingulate cortex (ACC). Other research has reported that the activity extending from the ACC to the medial prefrontal cortex (mPFC) is associated with impaired insight in patients with various disorders. Therefore, this project targets mPFC/ACC and uses deep transcranial magnetic stimulation (dTMS) for targeted modulation, with an exploratory observation of changes in patients' insight before and after neurostimulation.
CONDITIONS
Official Title
Study on Deep Transcranial Magnetic Stimulation for Enhancing Insight
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet criteria for clinical high risk for psychosis or diagnosis of schizophrenia by DSM-V
- Impaired insight defined by specific low scores on the Scale to Assess Unawareness of Mental Disorder (SAI)
- Completed at least six years of primary education
- Able to provide informed consent (oral consent for those under 18, with written consent from guardians)
You will not qualify if you...
- Currently participating in other clinical intervention studies
- Diagnosed with psychotic disorders including affective disorders
- Psychotic symptoms caused by other mental disorders or psychoactive substances
- On antipsychotic medication for more than 2 weeks
- Diagnosed with organic brain diseases or severe physical illnesses
- History of traumatic brain injury with a score of 7
- Diagnosis of dementia or intellectual disability (IQ below 70)
- Scalp infections
- Presence of pacemaker, metal implants, pregnancy, or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
L
Lihua Xu, Doctoral
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here