Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
https://pubmed.ncbi.nlm.nih.gov/24576776/Actively Recruiting
Led by MSD Italia S.r.l. · Updated on 2025-01-14
600
Participants Needed
25
Research Sites
N/A
Total Duration
Researchers are conducting a non-interventional, retrospective observational study to better understand the diagnosis and treatment of patients with early-stage and locally advanced non-small cell lung cancer NSCLC, specifically stages I to III. The study addresses the variability in treatment approaches, as there is no clear consensus on the best timing, sequence, or combination of surgery, chemotherapy, and radiotherapy for these patients. This research aims to collect real-world data to improve knowledge on how these patients are managed across different healthcare settings. This study involves reviewing past medical records of patients diagnosed with stage I-III NSCLC who underwent curative surgery or radiotherapy between January 2018 and June 2019. The data collection covers treatment approaches, discussions in multidisciplinary teams, healthcare resource use, and direct medical costs from January 2018 to January 2021. There are no interventions or treatments being given directly as part of this study since it is observational and retrospective. Participants involvement consists of allowing access to their medical charts and treatment records for data capture. Researchers will evaluate treatment timelines and approaches as they occurred in routine clinical practice. The study also tracks the extent of healthcare resources used and costs involved. Data privacy is maintained by obtaining informed consent from patients or their representatives. The study is expected to conclude in June 2025.
CONDITIONS
A Study to Describe the Diagnostic and Therapeutic Path of Patients with NSCLC in Early Stage and Locally Advanced
D
Daniele Righi, PM
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MSD Italia S.r.l.
Lead Sponsor
YGHEA, CRO Division of Ecol Studio spa
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Retrospective from January 2018 to January 2021
Participants undergo diagnostic assessments to characterize their NSCLC stage and plan treatment.
Data collected from medical charts during usual care
Duration - Retrospective from January 2018 to January 2021
Participants with stage I-III NSCLC are observed through their treatment path including surgery, chemotherapy, and radiotherapy as per routine clinical practice.
Follow-up visits and treatments as per standard care
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Lead Sponsor
YGHEA, CRO Division of Ecol Studio spa
Collaborating Sponsor