Actively Recruiting
Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer
Led by City of Hope Medical Center · Updated on 2025-09-16
30
Participants Needed
1
Research Sites
276 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study collects urine and stool samples to determine the ability to identify changes in the microbiome (bacteria, fungi, and viruses that live in the gut and urine) of patients with prostate cancer during androgen deprivation therapy and radiation therapy. Radiation therapy has the potential to harm the genitourinary area or the bowel, causing a feeling of urgency or increased inflammation in the area. The radiation therapy is designed to not irradiate the bowel and bladder areas, but there is still some radiation exposure. The gut microbiome has been associated with differences in inflammation as well as producing molecules that influence healing. The purpose of this study is to see whether the microbiome may contribute to the healing of the organs exposed to radiation. Information learned from this study may help researchers discover a new risk factor that could be manipulated to improve the quality of life in patients with prostate cancer.
CONDITIONS
Official Title
Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed prostate cancer with planned radiation therapy for definitive or salvage treatment or radiation without androgen deprivation therapy
- Cohort A: Gleason grade group 3 or higher with planned androgen deprivation therapy
- Cohort B: rising prostate-specific antigen and planned androgen deprivation therapy with salvage radiation
- Cohort C: radiation planned without androgen deprivation therapy
- Male patients aged 18 years or older
- Willing to provide urine and stool samples at specified times
You will not qualify if you...
- Men with inflammatory bowel disease
- Men with pre-existing cystitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
Research Team
T
Tanya B Dorff
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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