Actively Recruiting
A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
Led by M.D. Anderson Cancer Center · Updated on 2026-01-08
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new method to assess perioperative risk in patients with esophageal and lung cancer undergoing major cancer surgery. The study aims to understand how preoperative energy reserve capacity and cardiopulmonary gas exchange metabolism relate to postoperative complications. This observational study focuses on cancer patients receiving neoadjuvant therapies such as chemotherapy, radiation, or immunotherapy before surgery. Participants will undergo cardiopulmonary exercise testing (CPET), which involves pedaling on a stationary bicycle at a controlled speed with increasing resistance. These tests will be conducted before and after neoadjuvant therapy to measure various gas exchange parameters and functional capacity. The study seeks to link these measurements with postoperative outcomes to better predict surgical risks. During the study, participants will be monitored for morbid events up to 30 days after surgery. Assessments include CPET measures before and after treatment, as well as clinical evaluations by anesthesiologists and perioperative management teams. The study involves collecting laboratory and diagnostic data to ensure participants are fit for anesthesia and surgery, with a total observation period extending through the immediate postoperative phase.
CONDITIONS
Brief Title
A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants 18 years of age or older.
- Participants with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy.
- Participants who have signed the consent form to participate in the study.
- Participants must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist.
- All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed.
- All participants must be approved to undergo anesthesia by the standards of the POEM Center.
- No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.
You will not qualify if you...
- Participant is under age 18.
- Participant is unwilling to sign consent.
- Participant is unable to exercise (bedridden or wheel chair bound).
- Participant is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
- Participant's condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
- Participant has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina.
- Participant has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation.
- Participant has a history of a pulmonary embolic event within three months of the preanesthetic evaluation.
- Participant is known to have acute or chronic deep vein thrombosis.
- Participant is pregnant.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies depending on neoadjuvant therapy duration
Participants undergo cardiopulmonary exercise testing (CPET) before and after neoadjuvant therapy to measure functional capacity.
2 visits (in-person)
Duration - 30 days postoperatively
Participants are monitored for postoperative outcomes including morbid events.
Follow-up visits during 30 days after surgery
Trial Site Locations
Total: 1 location
1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
A
Anh Q Dang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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