Actively Recruiting
A Study to Develop Molecular Integrated Predictive Models of Breast Radio-toxicity (Precise-RTox)
Led by Centro di Riferimento Oncologico - Aviano · Updated on 2023-11-07
420
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Breast radiation treatment is burdened by acute and chronic toxicities, in most cases mild. However, considering the excellent life expectancy of patients with breast cancer, maintaining a low toxicity profile is of primary importance in order to guarantee a satisfactory quality of life. The definition of the molecular and genetic variables related to radiotoxicity and their integration into predictive molecular signatures may allow the risk of toxicity to be individualized. This would provide the clinician with a useful tool in order to personalize the radiation treatment, thus being able to choose the best technique or schedule for each patient.
CONDITIONS
Official Title
A Study to Develop Molecular Integrated Predictive Models of Breast Radio-toxicity (Precise-RTox)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to provide informed consent
- Diagnosed with distant nonmetastatic breast cancer
- Histology includes infiltrating NST (no special type), lobular carcinoma, or ductal carcinoma in situ
- Stage pTis; pT1-3 pN1-3 M0
- Any hormone receptor and HER-2 status
- Underwent breast-conserving surgery with negative surgical margins, including sentinel lymph node biopsy or axillary lymphadenectomy
- Candidates for postoperative radiation treatment
You will not qualify if you...
- Refusal to undergo radiotherapy treatment (no signed informed consent)
- Previous radiation therapy at the same site
- Receiving chemotherapy with anthracyclines or taxanes concurrently
- Unable to maintain treatment position
- Receiving partial breast radiotherapy (PBI)
- Male breast cancer
- Underwent mastectomy surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centro di Riferimento Oncologico (CRO) di Aviano - IRCCS
Aviano, Pordenone, Italy, 33081
Actively Recruiting
Research Team
L
Lorenzo Vinante, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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