Actively Recruiting
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
Led by Seagen, a wholly owned subsidiary of Pfizer · Updated on 2026-05-05
172
Participants Needed
141
Research Sites
270 weeks
Total Duration
On this page
Sponsors
S
Seagen, a wholly owned subsidiary of Pfizer
Lead Sponsor
R
RemeGen Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood. Once they've grown bigger in one spot or spread to other parts of the body, they're harder to treat. This is called advanced or metastatic cancer. Participants in this study must have breast cancer or gastric cancer. Participants must have tumors that have HER2 on them. This allows the cancer to grow more quickly or spread faster. There are few treatment options for patients with advanced or metastatic solid tumors that express HER2. This clinical trial uses an experimental drug called disitamab vedotin (DV). Disitamab vedotin is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. This clinical trial uses a drug called tucatinib, which has been approved to treat cancer in the United States and some other countries. This drug is sold under the brand name TUKYSA®. This study will test how safe and how well DV with tucatinib works for participants with solid tumors. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease.
CONDITIONS
Official Title
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Measurable disease according to RECIST v1.1
- ECOG Performance Status score of 0 or 1
- Histologically or cytologically confirmed breast carcinoma or gastric/gastroesophageal junction adenocarcinoma
- Locally-advanced, unresectable, or metastatic stage
- Experienced disease progression on or after standard therapies or intolerant of them
- For HER2-low breast cancer: HER2-low status (IHC 1+ or IHC 2+/ISH-negative)
- No more than 3 prior systemic chemotherapy regimens for locally advanced/metastatic breast cancer
- For known BRCA mutation, prior PARP-inhibitor treatment if available and not contraindicated
- Progression on or intolerance to certain therapies like T-DXd, sacituzumab govitecan, or topoisomerase I inhibitors
- For hormone receptor positive tumors, intolerance or refractory to endocrine therapy with specific prior treatments
- For HER2+ breast cancer: HER2+ status (IHC 3+ or IHC 2+/ISH+)
- Prior trastuzumab, pertuzumab, and taxane if available for advanced disease
- For HER2-low gastric cancer: HER2-low expression (IHC 1+ or IHC 2+/ISH-negative)
- Prior systemic therapy with platinum, fluorouracil, or taxane for advanced gastric cancer
- No prior HER2-directed therapy for HER2-low gastric cancer
- For HER2+ gastric cancer: HER2+ status (IHC 3+ or IHC 2+/ISH+)
- Prior trastuzumab plus fluoropyrimidine and platinum chemotherapy unless contraindicated
- No more than 2 prior systemic chemotherapy regimens for advanced gastric cancer
You will not qualify if you...
- Known allergy to disitamab vedotin or tucatinib or their ingredients
- Prior treatment with ADCs containing MMAE or prior tucatinib therapy
- Active central nervous system or leptomeningeal metastases
- Received systemic anticancer treatment including investigational agents within 4 weeks before study treatment
- History of other invasive cancers within 3 years or evidence of residual disease from previous cancers
- Unable to swallow oral medications or have gastrointestinal conditions preventing adequate absorption
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 141 locations
1
Banner-University Medical Center Tucson Campus
Tucson, Arizona, United States, 85704
Actively Recruiting
2
Banner-University Medical Center Tucson Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
3
The University of Arizona Cancer Center-North Campus Pharmacy, Attn: Kelly Myrdal
Tucson, Arizona, United States, 85719
Actively Recruiting
4
University of Arizona Cancer Center - North Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
5
The University of Arizona Cancer Center-Main
Tucson, Arizona, United States, 85724
Actively Recruiting
6
UC Irvine Health - Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868
Actively Recruiting
7
UC Irvine Medical Center
Orange, California, United States, 92868
Actively Recruiting
8
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies
San Francisco, California, United States, 94158
Actively Recruiting
9
UCLA Department of Medicine - Hematology & Oncology
Santa Monica, California, United States, 90404
Actively Recruiting
10
UCLA Hematology/Oncology - Parkside
Santa Monica, California, United States, 90404
Actively Recruiting
11
Colorado West Healthcare System, dba Community Hospital
Grand Junction, Colorado, United States, 81505
Not Yet Recruiting
12
Colorado West Healthcare, dba Grand Valley Oncology
Grand Junction, Colorado, United States, 81505
Not Yet Recruiting
13
Danbury Hospital
Danbury, Connecticut, United States, 06810
Not Yet Recruiting
14
Praxair Cancer Center / Danbury Hospital
Danbury, Connecticut, United States, 06810
Actively Recruiting
15
The Whittingham Cancer Center / Norwalk Hospital
Norwalk, Connecticut, United States, 06856
Not Yet Recruiting
16
Georgetown University Medical Center
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
17
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
18
Moffitt Cancer Center - International Plaza
Tampa, Florida, United States, 33607
Actively Recruiting
19
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612
Actively Recruiting
20
Moffitt Cancer Center - McKinley Campus
Tampa, Florida, United States, 33612
Actively Recruiting
21
Moffitt McKinley Hospital
Tampa, Florida, United States, 33612
Actively Recruiting
22
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel, Florida, United States, 33544
Actively Recruiting
23
Georgia Cancer Specialists - Athens
Athens, Georgia, United States, 30606
Actively Recruiting
24
Georgia Cancer Specialists - Annex
Atlanta, Georgia, United States, 30341
Actively Recruiting
25
Atlanta Cancer Care - Atlanta
Atlanta, Georgia, United States, 30342
Actively Recruiting
26
Georgia Cancer Specialists-Northside
Atlanta, Georgia, United States, 30342
Actively Recruiting
27
Northside Hospital, Inc.- Central Research Department
Atlanta, Georgia, United States, 30342
Actively Recruiting
28
Northside Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
29
Georgia Cancer Specialists - Blairsville
Blairsville, Georgia, United States, 30512
Actively Recruiting
30
Georgia Cancer Specialists - Canton
Canton, Georgia, United States, 30115
Actively Recruiting
31
Atlanta Cancer Care - Cumming
Cumming, Georgia, United States, 30041
Actively Recruiting
32
Georgia Cancer Specialists - Cumming
Cumming, Georgia, United States, 30041
Actively Recruiting
33
Georgia Cancer Specialists - Decatur
Decatur, Georgia, United States, 30033
Actively Recruiting
34
Suburban Hematology-Oncology Associates - Duluth
Duluth, Georgia, United States, 30096
Actively Recruiting
35
Suburban Hematology-Oncology Associates- Lawrenceville
Lawrenceville, Georgia, United States, 30046
Actively Recruiting
36
Georgia Cancer Specialists - Macon
Macon, Georgia, United States, 31217
Actively Recruiting
37
Georgia Cancer Specialists - Marietta
Marietta, Georgia, United States, 30060
Actively Recruiting
38
Memorial Hospital
Shiloh, Illinois, United States, 62269
Actively Recruiting
39
Siteman Cancer Center - Shiloh
Shiloh, Illinois, United States, 62269
Actively Recruiting
40
Massachusetts General Hospital.
Boston, Massachusetts, United States, 02114
Actively Recruiting
41
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
42
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
43
Dana Farber Cancer Institute- Chestnut Hill
Newton, Massachusetts, United States, 02459
Actively Recruiting
44
Siteman Cancer Center - St Peters
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
45
Siteman Cancer Center - West County
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
46
Siteman Cancer Center - North County
Florissant, Missouri, United States, 63031
Actively Recruiting
47
Saint Luke's Cancer Institute LLC
Kansas City, Missouri, United States, 64111
Actively Recruiting
48
Saint Luke's Hospital Investigational Pharmacy
Kansas City, Missouri, United States, 64111
Actively Recruiting
49
Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
50
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States, 63110
Actively Recruiting
51
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
52
Siteman Cancer Center - South County
St Louis, Missouri, United States, 63129
Actively Recruiting
53
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
54
MSK Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
55
MSK Monmouth.
Middletown, New Jersey, United States, 07748
Actively Recruiting
56
MSK Bergen.
Montvale, New Jersey, United States, 07645
Actively Recruiting
57
San Juan Oncology Associates
Farmington, New Mexico, United States, 87401
Terminated
58
MSK Commack.
Commack, New York, United States, 11725
Actively Recruiting
59
MSK Westchester.
Harrison, New York, United States, 10604
Actively Recruiting
60
Investigational Drug Service
Long Island City, New York, United States, 11101
Actively Recruiting
61
Memorial Sloan Kettering Cancer Center - Main Hospital
New York, New York, United States, 10065
Actively Recruiting
62
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
63
MSK Nassau.
Uniondale, New York, United States, 11553
Actively Recruiting
64
Zangmeister Cancer Center
Columbus, Ohio, United States, 43219
Actively Recruiting
65
Saint Francis Hospital / Bon Secours - South Carolina
Greenville, South Carolina, United States, 29607
Actively Recruiting
66
Sarah Cannon Research Institute - Pharmacy
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
67
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
68
Tennessee Oncology-Nashville/Sarah Cannon Research Institute
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
69
Parkland Health and Hospital System
Dallas, Texas, United States, 75235
Not Yet Recruiting
70
University of Texas Southwestern Medical Center - Simmons Cancer Center
Dallas, Texas, United States, 75235
Not Yet Recruiting
71
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy
Dallas, Texas, United States, 75235
Not Yet Recruiting
72
University of Texas Southwestern Medical Center Simmons Cancer Center - Redbird
Dallas, Texas, United States, 75237
Not Yet Recruiting
73
University of Texas Southwestern Medical Center Clinical Lab-Zale Lipshy University Hospital
Dallas, Texas, United States, 75390
Not Yet Recruiting
74
University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital
Dallas, Texas, United States, 75390
Not Yet Recruiting
75
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Not Yet Recruiting
76
University of Texas Southwestern Simmons Cancer Center - Fort Worth
Fort Worth, Texas, United States, 76104
Not Yet Recruiting
77
University of Texas Southwestern Medical Center Simmons Cancer Center - Richardson/Plano
Richardson, Texas, United States, 75080
Not Yet Recruiting
78
Harborview Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
79
Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of Washington
Seattle, Washington, United States, 98109
Actively Recruiting
80
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
81
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States, 53718
Actively Recruiting
82
Carbone Cancer Center / University of Wisconsin
Madison, Wisconsin, United States, 53792
Actively Recruiting
83
Peninsula & South Eastern Hematology and Oncology Group (PASO)
Frankston, Victoria, Australia, 3199
Not Yet Recruiting
84
Slade Pharmacy Frankston
Frankston, Victoria, Australia, 3199
Not Yet Recruiting
85
Peninsula & South Eastern Hematology and Oncology Group (PASO)
Frankston, Victoria, Australia
Not Yet Recruiting
86
Slade Health
Mount Waverley, Victoria, Australia, 3149
Not Yet Recruiting
87
Peter MacCallum Cancer Centre
Melbourne, Australia, 3000
Not Yet Recruiting
88
BC Cancer Kelowna.
Kelowna, British Columbia, Canada, V1Y 5L3
Actively Recruiting
89
Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
90
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
91
University Health Network - Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
92
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF)
Berlin, Germany, 12203
Actively Recruiting
93
Universitatsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
94
Heidelberg University Hospital and German Cancer Research Center
Heidelberg, Germany, 69120
Actively Recruiting
95
A.O.U. Federico II
Naples, Campania, Italy, 80131
Actively Recruiting
96
Azienda Ospedaliera Universitaria (AOU) Federico II
Naples, Campania, Italy, 80131
Actively Recruiting
97
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale.
Naples, Campania, Italy, 80131
Actively Recruiting
98
Istituto Europeo di Oncologia
Milan, Lombardy, Italy, 20141
Actively Recruiting
99
Humanitas Istituto Clinico Catanese
Misterbianco (CT), Sicily, Italy, 95045
Actively Recruiting
100
Azienda Ospedaliera Universitaria Integrata di Verona.
Verona, Veneto, Italy, 37134
Actively Recruiting
101
Niguarda Ca' Granda Hospital
Milan, Italy, 20162
Actively Recruiting
102
A.O.U. Federico II- U.O.C. Diagnostica per lmmagini e Radioterapia
Naples, Italy, 80131
Actively Recruiting
103
Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan, 135-8550
Not Yet Recruiting
104
Japanese Foundation for Cancer Research
Koto-ku, Tokyo, Japan, 135-8550
Not Yet Recruiting
105
Showa University Hospital
Shinagawa-ku, Tokyo-to, Japan, 142-8666
Not Yet Recruiting
106
Okayama University Hospital
Okayama, Japan, 700-8558
Not Yet Recruiting
107
Showa Medical University Hospital
Tokyo, Japan, 142-8666
Not Yet Recruiting
108
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
109
Dong-A University Hospital
Busan, Other, South Korea, 49201
Not Yet Recruiting
110
National Cancer Center
Goyang-si, Other, South Korea, 10408
Actively Recruiting
111
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03080
Actively Recruiting
112
Chungbuk National University Hospital
Cheongju-si, South Korea, 28644
Not Yet Recruiting
113
Gachon University Gil Medical Center
Incheon, South Korea, 21565
Not Yet Recruiting
114
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
115
Severance Hospital Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
116
St. Vincent's Hospital, The Catholic University of Korea
Suwon, South Korea, 16247
Not Yet Recruiting
117
Quirén Salud Barcelona
Barcelona, Spain, 08023
Actively Recruiting
118
Hospital Universitari Vall d´Hebron
Barcelona, Spain, 08035
Actively Recruiting
119
Institut Catala d'Oncologia
Barcelona, Spain, 08908
Actively Recruiting
120
CETIR Grup Medic
Barcelona, Spain, 08950
Actively Recruiting
121
Hospital Universitario de Basurto
Bilbao, Spain, 48013
Actively Recruiting
122
Grupo Hospitalario QuironSalud
Erandio Bizkaia, Spain, 48950
Actively Recruiting
123
Farmacia-Ensayos. Planta S - Hospital Universitario HM Sanchinarro-CIOCC-START Madrid
Madrid, Spain, 28050
Actively Recruiting
124
START Madrid-CIOCC_Hospital HM Sanchinarro
Madrid, Spain, 28050
Actively Recruiting
125
Ecg Medica Sl
Valencia, Spain, 46004
Actively Recruiting
126
Hospital Clinico Universitario de Valencia
Valencia, Spain, 46010
Actively Recruiting
127
National Cheng Kung University Hospital
Tainan, Taiwan, 704017
Not Yet Recruiting
128
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Not Yet Recruiting
129
National Taiwan University Hospital
Taipei, Taiwan, 100225
Not Yet Recruiting
130
National Taiwan University Hospital
Taipei, Taiwan, 100
Not Yet Recruiting
131
National Taiwan University Cancer Center
Taipei, Taiwan, 106
Not Yet Recruiting
132
Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan, 333
Not Yet Recruiting
133
Linkou Chang Gung Memorial Hospital
Taoyuan City, Taiwan, 333
Not Yet Recruiting
134
The Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
135
The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
136
St Bartholomew's Hospital
London, United Kingdom, EC1M 6BQ
Not Yet Recruiting
137
The Royal Marsden Hospital
London, United Kingdom, SW3 6JJ
Actively Recruiting
138
The Royal Marsden NHS Foundation Trust (RM)
London, United Kingdom, SW3 6JJ
Actively Recruiting
139
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW3 6JJ
Actively Recruiting
140
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4GJ
Not Yet Recruiting
141
The Royal Marsden NHS Foundation Trust
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
7
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