Actively Recruiting
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Led by National Institute of Environmental Health Sciences (NIEHS) · Updated on 2026-04-14
725
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: \- To examine how specific genes and proteins in blood cells respond to environmental exposures. Eligibility: \- Healthy volunteers between 18 and 45 years of age. Design: * The study will involve one visit of 45 to 60 minutes. * Participants will be screened with a brief physical examination and finger stick to determine if they are eligible to donate blood for the study, and will complete a questionnaire about any medications or other drugs (e.g., cigarettes) they may be taking. * Participants will provide a blood sample for research purposes.
CONDITIONS
Official Title
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 years of age or older
- Able to understand and provide written informed consent
- Able to travel to the clinical research unit
- Willing and able to fast after midnight before the study appointment
- Healthy as defined by International Red Cross guidelines, including controlled chronic conditions like diabetes or high blood pressure
You will not qualify if you...
- Use of nonsteroidal anti-inflammatory drugs within 5 days before enrollment
- Use of acetaminophen within 5 days before enrollment
- Use of cholesterol-lowering drugs (statins) within 30 days before enrollment
- Use of immunosuppressants, immune-modifying drugs, monoclonal antibodies, or corticosteroids
- Current cancer treatment with chemotherapy or radiation
- Confirmed or suspected immunosuppressive or immunodeficient condition
- Gastrointestinal or respiratory illness, including cold or allergies, within 5 days before enrollment
- Tobacco use, including smoking, chewing, or electronic cigarettes, within 2 weeks before enrollment
- Alcohol consumption exceeding 2 standard drinks in the 24 hours before enrollment
- Body weight less than 50 kg (110 lbs)
- Temperature over 37.6 C, blood pressure below 90/50 or above 170/95 mm Hg, pulse rate below 50 or above 100 beats per minute
- Pregnant or suspected pregnancy
- Chronic Kidney Disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, United States, 27709
Actively Recruiting
Research Team
N
NIEHS Join A Study Recruitment Group
CONTACT
M
Michael B Fessler, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
13
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