Actively Recruiting
A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)
Led by Actimed Therapeutics Ltd · Updated on 2026-02-17
120
Participants Needed
7
Research Sites
88 weeks
Total Duration
On this page
Sponsors
A
Actimed Therapeutics Ltd
Lead Sponsor
S
SCIRENT Clinical Research and Science d.o.o.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Semaglutide is approved for weight management (weight loss and weight maintenance) in adult obese patients. Drug treatments like semaglutide that result in weight-loss can also decrease muscle mass. The purpose of this study is to investigate the effect of ACM-001.1 (the study drug) on how much muscle is lost when a person takes it with semaglutide (PROACT 1) and how much muscle mass is gained when a person continues taking ACM-001.1 but stops taking semaglutide (PROACT 2).
CONDITIONS
Official Title
A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eligible for treatment with semaglutide
- Have a body mass index (BMI) of 30.0 kg/m² or higher
You will not qualify if you...
- Diagnosis of type 2 diabetes mellitus with any of the following in the past 90 days: use of GLP-1RA (including semaglutide), hypoglycemic event, weight loss greater than 5 kg, or HBA1C over 10.0%
- Cardiovascular event within the previous 6 months
- Uncontrolled hypertension
- Known congestive heart failure or angina during the past year
- Known severe chronic obstructive pulmonary disease (COPD)
- Use of beta blockers or contraindications to beta blockers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Clinical Hospital Center 'Dr Dragisa Misovic - Dedinje'
Belgrade, Serbia
Actively Recruiting
2
Clinical Hospital Center Bezanijska kosa
Belgrade, Serbia
Actively Recruiting
3
University Clinical Center of Serbia
Belgrade, Serbia
Actively Recruiting
4
University Clinical Center Kragujevac
Kragujevac, Serbia
Actively Recruiting
5
Klinika Za Endocrinologiju, Dijabetes I Bolesti Metabolizma
Niš, Serbia
Actively Recruiting
6
University Clinical Center of Vojvodina
Novi Sad, Serbia
Actively Recruiting
7
Opsta bolnica Pancevo
Pančevo, Serbia
Actively Recruiting
Research Team
F
Fabio Dorigotti, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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