Study of Tong-Xie-Yao-Fang Effects on Immune Balance and Metabolism in Adults with Diarrhea-Predominant Irritable Bowel Syndrome

What this Trial Is About

Diarrhea-predominant irritable bowel syndrome IBS-D is a common digestive disorder often linked to emotional factors, with unclear causes and no specific treatment. Traditional Chinese Medicine TCM sees liver depression and spleen deficiency as key issues and uses the classic Tong-Xie-Yao-Fang TXYF formula to soothe the liver and strengthen the spleen. Researchers are studying the effects and mechanisms of TXYF on IBS-D by examining its impact on intestinal flora and host metabolism through metabolomics and metagenomics techniques. The study evaluates the use of Tong-Xie-Yao-Fang granules taken twice daily, one hour after meals, for four weeks in patients with IBS-D. It includes an experimental group receiving TXYF and a healthy volunteer group without intervention. The research aims to clarify how TXYF influences the balance of immune and metabolic pathways related to IBS-D, focusing on the Trp-Kyn-AhR pathway and intestinal flora changes. Participants will provide samples of blood, urine, stool, and colon tissue for various tests over 16 weeks. These tests include measuring bacteria associated with tryptophan metabolism, assessing serum markers, and analyzing immune cell ratios and colon tissue through advanced laboratory methods. The study will monitor these outcomes to better understand TXYFs role in regulating immune balance and metabolism in IBS-D, with a total participation duration of 16 weeks.

Study on the Effectiveness and Mechanism of Tong-Xie-Yao-Fang in Treating Diarrhea-predominant Irritable Bowel Syndrome