Actively Recruiting
Study on the Effects of Drugs That Modulate the Endocannabinoid System on Spontaneous and Induced Contractility of the Human Detrusor Muscle
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2026-04-22
65
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational, in vitro study is to evaluate the effects of drugs that modulate the endocannabinoid system on spontaneous and neuronally induced contractility of the human detrusor. The study will include adult patients undergoing elective radical cystectomy for bladder cancer. The main questions it aims to answer are whether modulation of endocannabinoid receptors, enzymes involved in endocannabinoid synthesis and degradation, and endocannabinoid transport mechanisms alters basal detrusor contractility and modifies excitatory motor responses induced by neuronal activation. Participants undergoing radical cystectomy will provide written informed consent for the collection of a small sample of macroscopically healthy bladder tissue from the surgical specimen. Detrusor muscle strips will be prepared and studied in vitro using organ bath techniques. Contractile activity will be recorded under baseline conditions and after electrical field stimulation, as well as following exposure to pharmacological modulators of the endocannabinoid system. Demographic, clinical, and pathological data will also be collected for descriptive analysis.
CONDITIONS
Official Title
Study on the Effects of Drugs That Modulate the Endocannabinoid System on Spontaneous and Induced Contractility of the Human Detrusor Muscle
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patients with bladder carcinoma at any stage scheduled for curative or demolitive surgery
- Patients undergoing upfront surgery or neoadjuvant therapy for more than 6 weeks
- Signed written informed consent to participate in the study
You will not qualify if you...
- Age under 18 years
- Procedures performed on an urgent or emergency basis
- Patients receiving corticosteroid therapy for immunorheumatic diseases
- Patients treated with radio-chemotherapy and undergoing surgery less than 6 weeks prior
- Refusal to sign written informed consent to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli, 100168 - Roma
Rome, Italy
Actively Recruiting
Research Team
M
MARIA CHIARA SIGHINOLFI, DR
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here