Actively Recruiting
Dose-response of Aerobic Training During Chemotherapy for Gastrointestinal Cancers
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-16
216
Participants Needed
8
Research Sites
6 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of different levels of aerobic exercise on reducing side effects in people receiving treatment for gastrointestinal cancers, including colorectal and esophago/gastric solid tumors. This phase 2 study aims to find safe, practical exercise doses that may improve how the body responds to chemotherapy and affect treatment outcomes like dose delivery and side effect management. The study also examines how exercise might influence treatment delays, reductions, or additional medication use. Participants will be randomly assigned to one of three groups with different weekly amounts of treadmill walking: 90, 150, or 300 minutes per week. The exercise sessions are individualized and supervised using TeleEx technology to track progress, following a non-linear schedule with rest and recovery. The exercise program runs throughout chemotherapy treatment, and staff will ensure participants have access to Wi-Fi and treadmills, providing tablets or local gym access if needed. During the study, participants will be assessed on their ability to complete planned chemotherapy doses, aiming for a ratio of delivered to planned treatment of 90% or higher over 5 years. Researchers will monitor adherence to the exercise program and evaluate physical responses using remote supervision. The total participation time varies with chemotherapy duration, and safety and treatment outcomes will be closely observed throughout the study period.
CONDITIONS
Brief Title
A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Diagnosed with colorectal or esophago/gastric solid tumors confirmed by histology or standard imaging
- Scheduled to receive neoadjuvant chemotherapy or chemotherapy for newly diagnosed metastatic disease
- Performing 90 minutes or less of structured moderate-intensity or strenuous-intensity exercise per week
- Willing to comply with all study-related procedures
- Cleared for exercise participation via the Physical Activity Readiness Questionnaire
You will not qualify if you...
- Enrolled in any other lifestyle interventional investigational study unless approved by the principal investigator
- Receiving treatment for any other invasive cancer diagnosis
- Having mental impairment that prevents cooperation
- Having any other condition or illness that makes participation unsafe or unsuitable according to the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - Duration of chemotherapy treatment
Participants undergo aerobic training consisting of individualized treadmill walking up to 7 times per week during chemotherapy. Training dose is adjusted non-linearly with rest and recovery sessions throughout the treatment period and monitored remotely.
Weekly visits for monitoring and supervised aerobic training
Trial Site Locations
Total: 8 locations
1
Hartford Healthcare Alliance (Data Collection Only)
Hartford, Connecticut, United States, 06102
Actively Recruiting
2
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
3
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
4
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
5
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
6
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
8
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
J
Jessica Scott, PhD
A
Andrea Cercek, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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