Actively Recruiting
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
Led by Erasmus Medical Center · Updated on 2025-12-17
430
Participants Needed
14
Research Sites
260 weeks
Total Duration
On this page
Sponsors
E
Erasmus Medical Center
Lead Sponsor
D
Dutch Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded. These trial domains will, in a perpetual way, study the effects of a range of patient management strategies which aim to improve VA ECMO weaning success. A first trial domain will address the effects of left ventricular (LV) unloading through intra-aortic balloon pumping on weaning succes in VA ECMO supported patients.
CONDITIONS
Official Title
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Having received ECMO support for severe circulatory and/or respiratory insufficiency
- Cardiogenic shock
- Having received VA ECMO support for severe circulatory (and respiratory) insufficiency
- Age 18 years or older
- Left ventricular unloading (IABP or Impella) can be initiated within 8 hours after ECMO start
You will not qualify if you...
- Objecting to participation in the registry by patient or proxy
- VA ECMO used only during surgery or intervention and removed afterwards
- No or deferred informed consent provided by patient or proxy
- Pregnancy
- Isolated right ventricular failure (e.g., pulmonary embolism)
- Existing left ventricular assist device (LVAD), Impella or IABP in place
- Ventricular septal defect or papillary muscle rupture causing shock
- Thoracic or abdominal aortic dissection
- Moderate or severe aortic regurgitation
- Mechanical prosthesis in mitral valve position
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
AZ Sint-Jan Brugge
Bruges, Belgium
Actively Recruiting
2
ZOL Genk
Genk, Belgium
Actively Recruiting
3
UZ Gent
Ghent, Belgium
Actively Recruiting
4
Amphia hospital
Breda, North Brabant, Netherlands, 4818 CK
Not Yet Recruiting
5
Catharina hospital
Eindhoven, North Brabant, Netherlands, 5623 EJ
Not Yet Recruiting
6
Amsterdam University Medical Center
Amsterdam, North Holland, Netherlands, 1105 AZ
Not Yet Recruiting
7
Leiden University Medical Center
Leiden, South Holland, Netherlands, 2333 ZA
Not Yet Recruiting
8
Erasmus Medical Center
Rotterdam, South Holland, Netherlands, 3015 GD
Actively Recruiting
9
Haga ziekenhuis
The Hague, South Holland, Netherlands, 2545 AA
Not Yet Recruiting
10
Antonius hospital
Nieuwegein, Utrecht, Netherlands, 3435 CM
Not Yet Recruiting
11
University Medical Center Utrecht
Utrecht, Utrecht, Netherlands, 3584 CX
Not Yet Recruiting
12
OLVG
Amsterdam, Netherlands
Actively Recruiting
13
Maastricht UMC
Maastricht, Netherlands
Actively Recruiting
14
Radboud UMC
Nijmegen, Netherlands
Actively Recruiting
Research Team
M
Myrthe van Steenwijk
CONTACT
C
Christiaan Meuwese
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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