Actively Recruiting
A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA
Led by Qianfoshan Hospital · Updated on 2026-01-23
44
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the efficacy and safety of bronchoscopic airway clearance and amphotericin B spraying in the treatment of allergic bronchopulmonary aspergillosis
CONDITIONS
Official Title
A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the diagnostic criteria for allergic bronchopulmonary aspergillosis according to ISHAM 2024 guidelines
- Presence of mucus plugs or hyperattenuated mucus confirmed by chest high-resolution CT
- Active disease defined as newly diagnosed ABPA or acute exacerbation after treatment discontinuation with clinical worsening and at least 50% increase in total serum IgE
- Age 18 years or older
You will not qualify if you...
- ABPA serotype with no obvious abnormality on chest CT
- Contraindications to electronic bronchoscopy
- Allergy to amphotericin B or its excipients
- Bronchiectasis caused by HIV infection, active tuberculosis, pulmonary malignant tumor, or other non-ABPA causes
- Other diseases requiring long-term systemic glucocorticoids or immunosuppressants
- Previous or current smoking history
- Pregnant or lactating women
- Participation in other interventional clinical research
- Conditions preventing study participation such as nonadherence, predicted survival less than 1 year, or severe mental illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China
Jinan, Shandong, China, 250014
Actively Recruiting
Research Team
Q
Qian Qi, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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