Actively Recruiting
Study of Efficacy and Safety of HB0017 in Patients With Moderate to Severe Plaque Psoriasis
Led by Huabo Biopharm Co., Ltd. · Updated on 2024-06-27
400
Participants Needed
44
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, randomized, double-blind, placebo-controlled, phase III clinical study which is designed to determine the efficacy, safety, immunogenicity and pharmacokinetics, and pharmacodynamics of HB0017 Injection in the treatment of moderate to severe plaque psoriasis in adults.
CONDITIONS
Official Title
Study of Efficacy and Safety of HB0017 in Patients With Moderate to Severe Plaque Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female subjects aged 18-75 years (inclusive)
- Chronic plaque psoriasis for at least 6 months prior to randomization
- Psoriasis Area Severity Index (PASI) ≥12 and body surface area affected by psoriasis ≥10%
- Static Physician Global Assessment (sPGA) score ≥3
- Suitable for systemic treatment or phototherapy for psoriasis as judged by the investigator
- Able to use effective contraception from screening to 6 months after last dose
You will not qualify if you...
- Forms of psoriasis other than chronic plaque-type (e.g., pustular, erythrodermic, guttate) at screening or baseline
- Drug-induced psoriasis
- Ongoing use of prohibited treatments
- Any active infection other than common cold within 14 days
- Serious infection requiring hospitalization or intravenous anti-infectives within 1 month prior to randomization
- Previous treatment with drugs targeting IL-17 or IL-17 receptor
- Recent use of biologic agents within specified washout periods before randomization
- History of inflammatory bowel disease or serious autoimmune disease
- Previously diagnosed with serious mental illness such as anxiety, depression, or suicidal tendency
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 44 locations
1
Jiangmen Central Hospital
Jiangmen, Guangdong, China
Not Yet Recruiting
2
Nanyang First People's Hospital
Nanyang, Henan, China
Actively Recruiting
3
Beijing Friendship Hospital
Beijing, China
Actively Recruiting
4
China-Japan Friendship hospital
Beijing, China
Actively Recruiting
5
Peking University People's Hospital
Beijing, China
Actively Recruiting
6
The First Affiliated Hospital of Bengbu Medical College
Bengbu, China
Actively Recruiting
7
Jilin University Second Hospital
Changchun, China
Actively Recruiting
8
The first hospital of Jilin University
Changchun, China
Actively Recruiting
9
Xiangya Hospital of Central South University
Changsha, China
Actively Recruiting
10
Affiliated Hospital of Chengde Medical University
Chengde, China
Actively Recruiting
11
Sichuan Provincial People's Hospital
Chengdu, China
Not Yet Recruiting
12
West China Hospital of Sichuan University
Chengdu, China
Not Yet Recruiting
13
Chongqing Traditional Chinese Medicine Hospital
Chongqing, China
Not Yet Recruiting
14
Dongguan People's Hospital
Dongguan, China
Actively Recruiting
15
The First Affiliated Hospital of Fujian Medical University
Fuzhou, China
Actively Recruiting
16
Dermatology Hospital of Southern Medical University
Guangzhou, China
Actively Recruiting
17
Guangdong Provincial People's Hospital
Guangzhou, China
Actively Recruiting
18
Hangzhou First People's Hospital
Hangzhou, China
Actively Recruiting
19
Hangzhou Third People's Hospital
Hangzhou, China
Not Yet Recruiting
20
The First Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Not Yet Recruiting
21
The Second Affiliated Hospital of Harbin Medical University
Harbin, China
Actively Recruiting
22
The Second Affiliated Hospital of Anhui Medical University
Hefei, China
Actively Recruiting
23
Jiaxing First Hospital
Jiaxing, China
Actively Recruiting
24
Shandong Dermatology Hospital
Jinan, China
Actively Recruiting
25
Jining First People's Hospital
Jining, China
Not Yet Recruiting
26
The First Affiliated Hospital of Kunming Medical University
Kunming, China
Actively Recruiting
27
The Second Affiliated Hospital of Kunming Medical University
Kunming, China
Actively Recruiting
28
The Second Affiliated Hospital of Henan University of Science and Technology
Luoyang, China
Actively Recruiting
29
Dermatology Hospital of Jiangxi Province
Nanchang, China
Actively Recruiting
30
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Actively Recruiting
31
Jiangsu University Affiliated Hospital
Nanjing, China
Actively Recruiting
32
Ningbo Second Hospital
Ningbo, China
Actively Recruiting
33
Shanghai Dermatology Hospital
Shanghai, China
Actively Recruiting
34
People's Hospital of Liaoning Province
Shenyang, China
Actively Recruiting
35
Shenzhen People's Hospital
Shenzhen, China
Actively Recruiting
36
Shiyan People's Hospital
Shiyan, China
Actively Recruiting
37
The Second Hospital of Shanxi Medical University
Taiyuan, China
Actively Recruiting
38
Wenzhou Medical University Affiliated First Hospital
Wenzhou, China
Actively Recruiting
39
Wuhan University People's Hospital
Wuhan, China
Actively Recruiting
40
The First Affiliated Hospital of Wannan Medical College
Wuhu, China
Actively Recruiting
41
Wuxi Second People's Hospital
Wuxi, China
Actively Recruiting
42
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Actively Recruiting
43
Xingtai People's Hospital
Xingtai, China
Actively Recruiting
44
Yangjiang People's Hospital
Yangjiang, China
Not Yet Recruiting
Research Team
J
Jianzhong Zhang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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