Actively Recruiting
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Led by Children's Hospital of Fudan University · Updated on 2026-03-16
60
Participants Needed
1
Research Sites
334 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Fudan University
Lead Sponsor
S
Shanghai Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia, and organ failure. The difficulty of clinical treatment is microcirculation and mitochondrial dysfunction in septic shock. Once shock enters the stage of microcirculation failure, conventional treatment is ineffective. ECMO can effectively support the circulatory system and provide good oxygen delivery, but there are many controversies in clinical treatment. 1) whether ECMO can effectively improve the clinical prognosis of children with septic shock; 2) appropriate timing for ECMO intervention; 3) which key clinical factors affect the effect of ECMO treatment. This study intends to adopt a multi-center, prospective, non-randomized controlled trial design, and the main research hypothesis is whether ECMO treatment can improve the success of discharge survival of children with septic shock.
CONDITIONS
Official Title
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children with septic shock and refractory septic shock admitted to the PICU of all the study centers
You will not qualify if you...
- Fatal chromosomal abnormalities (e.g., trisomy 13 or 18)
- Uncontrolled bleeding
- Irreversible brain damage
- After allogeneic bone marrow transplantation
- Weight less than 2.5kg or severe malnutrition
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Children'S Hosptial of Fuan University
Shanghai, China
Actively Recruiting
Research Team
G
Guoping Lu, Doctor
CONTACT
Y
Ye Cheng, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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