Actively Recruiting
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
Led by Eli Lilly and Company · Updated on 2026-04-20
140
Participants Needed
207
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).
CONDITIONS
Official Title
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have had an established diagnosis of UC of �3 months in duration before baseline.
- Have moderately to severely active UC as assessed by the UC disease activity score.
- Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators).
- Are on a stable dose of certain oral UC medications (including corticosteroids).
- Must meet contraception requirements.
You will not qualify if you...
- Have received anti-interleukin (IL)-23p19 or anti-IL-12p40 antibodies in the past.
- Have experienced a thrombotic event within 24 weeks before baseline.
- Have a current diagnosis of Crohn's Disease or certain other inflammatory gastrointestinal diseases.
- Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study.
- Have a history of certain adenomas, dysplasia's, or malignancies.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 207 locations
1
AZ Gastro Care - Chandler
Chandler, Arizona, United States, 85225
Not Yet Recruiting
2
Applied Research Center of Arkansas
Little Rock, Arkansas, United States, 72205
Actively Recruiting
3
Preferred Research Partners
Little Rock, Arkansas, United States, 72211
Not Yet Recruiting
4
Erick Alayo Medical Corp/Gastro SB Clinic
Chula Vista, California, United States, 91910
Actively Recruiting
5
Southern California GI and Liver Centers (SCLC)
Coronado, California, United States, 92118
Actively Recruiting
6
Valley View Research
Garden Grove, California, United States, 92845
Actively Recruiting
7
Om Research, LLC
Lancaster, California, United States, 93534
Actively Recruiting
8
United Medical Doctors
Los Alamitos, California, United States, 90720-3433
Actively Recruiting
9
Clinnova Research
Orange, California, United States, 92868-4402
Actively Recruiting
10
Prospective Research Innovations
Rancho Cucamonga, California, United States, 91730-4850
Actively Recruiting
11
Clinical Trials Management Services, LLC
Thousand Oaks, California, United States, 91360
Actively Recruiting
12
Om Research LLC
Victorville, California, United States, 92395
Actively Recruiting
13
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States, 80907-6262
Actively Recruiting
14
Medical Research Center of Connecticut, LLC
Hamden, Connecticut, United States, 06518-3602
Actively Recruiting
15
Novum Research, LLC
Clermont, Florida, United States, 34711
Not Yet Recruiting
16
I.V.A.M. Clinical & Investigational Center, LLC
Doral, Florida, United States, 33126
Not Yet Recruiting
17
Florida Research Institute
Lakewood Rch, Florida, United States, 34211
Not Yet Recruiting
18
Well Pharma Medical Research Corp.
Miami, Florida, United States, 33173
Actively Recruiting
19
Reserka
Miami, Florida, United States, 33176
Not Yet Recruiting
20
Digestive Disease Consultants DDCJAX
Orange Park, Florida, United States, 32073-4752
Not Yet Recruiting
21
Orlando Health Digestive Health Institute
Orlando, Florida, United States, 32803-1248
Actively Recruiting
22
AdventHealth Orlando
Orlando, Florida, United States, 32803
Not Yet Recruiting
23
Nodal Medical Center
Tampa, Florida, United States, 33607
Actively Recruiting
24
Research Bay,Inc.
Tampa, Florida, United States, 33607
Actively Recruiting
25
GCP Clinical Research, LLC
Tampa, Florida, United States, 33609
Actively Recruiting
26
International Center for Research LLC
Tampa, Florida, United States, 33614
Actively Recruiting
27
Northwestern University
Chicago, Illinois, United States, 60611
Not Yet Recruiting
28
Avicenna Clinical Research - SW Gastroenterology
Oak Lawn, Illinois, United States, 60453-3754
Actively Recruiting
29
Clinical Trials Management, LLC
Metairie, Louisiana, United States, 70006
Not Yet Recruiting
30
Gastroenterology Associates of Western Michigan, P.L.C.
Wyoming, Michigan, United States, 49519
Actively Recruiting
31
Ellipsis Research Group
Brooklyn, New York, United States, 11215
Actively Recruiting
32
Smart Medical Research - Jackson Heights
Jackson Heights, New York, United States, 11372
Actively Recruiting
33
Pioneer Clinical Research NY
New York, New York, United States, 10012-3645
Actively Recruiting
34
Digestive Disease Medicine of Central New York
Utica, New York, United States, 13502
Actively Recruiting
35
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
36
GCGA Physicians, LLC dba / Gastro Health Research
Cincinnati, Ohio, United States, 45219
Actively Recruiting
37
NexGen Research
Lima, Ohio, United States, 45801
Actively Recruiting
38
Inquest Clinical Research
Baytown, Texas, United States, 77521
Actively Recruiting
39
DHR Health Gastroenterology - Edinburg
Edinburg, Texas, United States, 78539
Actively Recruiting
40
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
41
Intergrity Research
Houston, Texas, United States, 77043
Actively Recruiting
42
Gastroenterology Research of San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
43
Tyler Research Institute
Tyler, Texas, United States, 75701
Actively Recruiting
44
Care Access-Ogden
Ogden, Utah, United States, 84403
Actively Recruiting
45
Advanced Research Institute - South Ogden
Ogden, Utah, United States, 84405
Actively Recruiting
46
University of Washington School Medicine
Seattle, Washington, United States, 98195
Not Yet Recruiting
47
CIPREC
CABA, Argentina, C1061AAS
Actively Recruiting
48
Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
Ciudad Autonoma de Buenos Air, Argentina, C1128AAF
Actively Recruiting
49
Clínica Privada Independencia
Munro, Argentina, 1605
Not Yet Recruiting
50
CER Instituto Medico
Quilmes, Argentina, B1878DVB
Not Yet Recruiting
51
Hospital Provincial del Centenario
Rosario, Argentina, S2002KDS
Actively Recruiting
52
Centro Medico Privado de Reumatologia
SAN M. de Tucuman, Argentina, T4000AXL
Actively Recruiting
53
Chu Tivoli
La Louvière, Belgium, 7100
Actively Recruiting
54
CHU UCL Namur site Godinne
Yvoir, Belgium, 5530
Actively Recruiting
55
London Health Sciences Centre
London, Canada, N6A 5W9
Actively Recruiting
56
London Digestive Disease Institute
London, Canada, N6K 1M6
Not Yet Recruiting
57
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Canada, H1T 2M4
Not Yet Recruiting
58
Montreal General Hospital
Montreal, Canada, H3G 1A4
Not Yet Recruiting
59
Hospital Universitario Mayor Méderi
Bogotá, Colombia, 111411
Not Yet Recruiting
60
Comité de Ética en Investigación Biomédica IPS Centro Médico Julián Coronel
Cali, Colombia, 750035
Not Yet Recruiting
61
Centro de Inmunología y Genética (CIGE)
Medellín, Colombia, 5001000
Not Yet Recruiting
62
General Hospital Dr Andjelko Visic Bjelovar
Bjelovar, Croatia, 43000
Actively Recruiting
63
Poliklinika Borzan
Osijek, Croatia, 31000
Actively Recruiting
64
Special Hospital Medico
Rijeka, Croatia, 51000
Actively Recruiting
65
General Hospital Dr. J. Bencevic
Slavonski Brod, Croatia, 35 000
Not Yet Recruiting
66
Poliklinika Solmed
Zagreb, Croatia, 10000
Actively Recruiting
67
University Hospital Center Zagreb
Zagreb, Croatia, 10000
Not Yet Recruiting
68
SurGal clinic s.r.o.
Brno, Czechia, 60200
Not Yet Recruiting
69
Vojenska nemocnice Brno p.o.
Brno, Czechia, 615 00
Actively Recruiting
70
Etická komise Nemocnice Slaný
Slaný, Czechia, 27401
Actively Recruiting
71
Etická komise Krajské nemocnice T. Bati, a. s.
Zlín, Czechia, 762 75
Actively Recruiting
72
Bispebjerg Hospital
København NV, Denmark, 2400
Not Yet Recruiting
73
Henri Mondor Hospital
Créteil, France, 94010
Actively Recruiting
74
CHU De Grenoble Hopital Albert Michallon
Grenoble, France, 38043
Actively Recruiting
75
Centre Hospitalier Departemental (CHD) Vendee
La Roche-sur-Yon, France, 85925
Actively Recruiting
76
CHU de Nice Hopital de L'Archet
Nice, France, 06202
Actively Recruiting
77
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
Pierre-Bénite, France, 69495
Actively Recruiting
78
Chu de Rouen Hopital Charles Nicolle
Rouen, France, 76031
Actively Recruiting
79
Universitätsklinikum Augsburg, III. Medizinische Klinik Studienzentrum
Augsburg, Germany, 86156
Actively Recruiting
80
Charité Campus Virchow-Klinikum
Berlin, Germany, 13353
Actively Recruiting
81
Universitätsklinikum Brandenburg GmbH
Brandenburg an der Havel, Germany, 14770
Actively Recruiting
82
MVZ für spezialärztliche Versorgung Dr. Friedrichs GmbH
Duisburg, Germany, 47055
Actively Recruiting
83
Universitätsklinikum Frankfurt Goethe-Universität, Medizinische Klinik 1
Frankfurt am Main, Germany, 60590
Actively Recruiting
84
Interdisziplinäres Crohn Colitis Centrum Rhein-Main
Frankfurt am Main, Germany, 60594
Not Yet Recruiting
85
Studiengesellschaft BSF Unternehmergesellschaft
Halle, Germany, 06108
Actively Recruiting
86
HaFCED e.K. - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
Hamburg, Germany, 20251
Not Yet Recruiting
87
Medizinische Hochschule Hannover
Hanover, Germany, 30625
Actively Recruiting
88
Universitätsklinikum Schleswig-Holstein
Kiel, Germany, 24105
Actively Recruiting
89
Klinikum Rechts der Isar der TU München
München, Germany, 81675
Actively Recruiting
90
Magen-Darm-Zentrum Remscheid
Remscheid, Germany, 42859
Actively Recruiting
91
Universitätsklinikum Ulm
Ulm, Germany, 89081
Not Yet Recruiting
92
General Hospital of Athens 'Evangelismos'
Athens, Greece, 10676
Actively Recruiting
93
General Hospital of Athens Hippokratio
Athens, Greece, 115 27
Actively Recruiting
94
Sotiria Thoracic Diseases Hospital of Athens
Athens, Greece, 11527
Actively Recruiting
95
Alexandra Hospital
Athens, Greece, 11528
Actively Recruiting
96
PAGNI-University General Hospital of Heraklion
Heraklion, Greece, 71500
Actively Recruiting
97
University Hospital of Ioannina
Ioannina, Greece, 45500
Actively Recruiting
98
General Oncology Hospital of Kifissia "Agioi Anargiroi"
Nea Kifissia, Greece, 14564
Not Yet Recruiting
99
Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft
Budapest, Hungary, 1033
Actively Recruiting
100
Óbudai Egészségügyi Centrum
Budapest, Hungary, 1036
Actively Recruiting
101
Semmelweis University
Budapest, Hungary, 1088
Actively Recruiting
102
Bugát Pál Kórház
Gyöngyös, Hungary, 3200
Not Yet Recruiting
103
Clinexpert Gyöngyös Kft.
Gyöngyös, Hungary, 3200
Not Yet Recruiting
104
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, Hungary, 6725
Not Yet Recruiting
105
Fejér Megyei Szent György Egyetemi Oktató Kórház
Székesfehérvár, Hungary, 8000
Actively Recruiting
106
Beaumont Hospital, Dublin
Dublin, Ireland, D9
Actively Recruiting
107
IRCCS - AOU di Bologna
Bologna, Italy, 40138
Actively Recruiting
108
Fondazione Poliambulanza
Brescia, Italy, 25124
Not Yet Recruiting
109
AST Pesaro Urbino - Presidio Ospedaliero Santa Croce
Fano, Italy, 61032
Actively Recruiting
110
Azienda Ospedaliera Universitaria Careggi
Florence, Italy, 50134
Actively Recruiting
111
A.O.U. Policlinico G. Martino
Gazzi - Messina, Italy, 98125
Actively Recruiting
112
Ospedale S. Paolo
Milan, Italy, 20142
Actively Recruiting
113
Azienda Ospedaliero Universitaria
Modena, Italy, 41124
Not Yet Recruiting
114
Università di Cagliari - Presidio Policlinico Monserrato
Monserrato, Italy, 09042
Actively Recruiting
115
Azienda Ospedale Università di Padova
Padova, Italy, 35128
Actively Recruiting
116
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
117
Policlinico Tor Vergata
Roma, Italy, 00133
Actively Recruiting
118
Ospedale Sandro Pertini
Roma, Italy, 157
Not Yet Recruiting
119
Policlinico Universitario Campus Bio-Medico
Rome, Italy, 00128
Actively Recruiting
120
Istituto Clinico Humanitas
Rozzano, Italy, 20089
Actively Recruiting
121
IRCCS Policlinico San Donato
San Donato Milanese, Italy, 20097
Actively Recruiting
122
IRCCS Ospedale Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy, 71013
Actively Recruiting
123
IRCCS Ospedale San Raffaele
Segrate, Italy, 20132
Actively Recruiting
124
A.O.U. Citta' della Salute e della Scienza di Torino
Torino, Italy, 10126
Actively Recruiting
125
SC Farmacia AO Ordine Mauriziano
Torino, Italy, 10128
Actively Recruiting
126
Chiba University Hospital
Chiba, Japan, 260-8677
Not Yet Recruiting
127
Fukuoka University Chikushi Hospital
Chikushino-shi, Japan, 818-8502
Actively Recruiting
128
Saiseikai Fukuoka General Hospital
Fukuoak, Japan, 810-0001
Not Yet Recruiting
129
Hachinohe City Hospital
Hachinohe-shi, Japan, 031-8555
Not Yet Recruiting
130
National Hospital Organization Hirosaki General Medical Center
Hirosaki, Japan, 036-8545
Not Yet Recruiting
131
Hiroshima City North Medical Center Asa Citizens Hospital
Hiroshima, Japan, 731-0293
Actively Recruiting
132
Hiroshima University Hospital
Hiroshima, Japan, 734-8551
Not Yet Recruiting
133
Tokai University Hospital
Isehara, Japan, 259-1193
Actively Recruiting
134
Isesaki Municipal Hospital
Isesaki-shi, Japan, 372-0817
Actively Recruiting
135
Kagoshima IBD Gastroenterology Clinic
Kagoshima, Japan, 892-0843
Actively Recruiting
136
National Hospital Organization Kanazawa Medical Center
Kanazawa, Japan, 920-8650
Not Yet Recruiting
137
Tsujinaka Hospital Kashiwanoha
Kashiwa, Japan, 277-0871
Actively Recruiting
138
JCHO Kyushu Hospital
Kitakyushu-Shi, Japan, 806 8501
Not Yet Recruiting
139
Yamanashi Prefectural Central Hospital
Kofu, Japan, 400-8506
Not Yet Recruiting
140
Hoshi General Hospital Foundation
Koriyama-shi, Japan, 963-8801
Not Yet Recruiting
141
Showa University Koto Toyosu Hospital
Kōtoku, Japan, 135 8577
Not Yet Recruiting
142
Our Lady of the Snow St. Mary's Hospital
Kurume-shi, Japan, 830 8543
Not Yet Recruiting
143
Kitasato University Kitasato Institute Hospital
Minatoku, Japan, 108 8642
Actively Recruiting
144
Kyorin University Hospital
Mitaka, Japan, 181-8611
Actively Recruiting
145
Iwate Medical University Hospital
Morioka, Japan, 020-8505
Actively Recruiting
146
Nara Prefecture General Medical Center
Nara, Japan, 630-8054
Actively Recruiting
147
Hyogo College of Medicine
Nishinomiya, Japan, 663-8501
Actively Recruiting
148
Infusion Clinic
Osaka, Japan, 530-0011
Actively Recruiting
149
Oita Red Cross Hospital
Ōita, Japan, 870-0033
Not Yet Recruiting
150
Sapporo Higashi Tokushukai Hospital
Sapporo, Japan, 065-0033
Actively Recruiting
151
Tokushukai Sapporo Tokushukai Hospital
Sapporo, Japan, 40041
Actively Recruiting
152
Sapporo IBD Clinic
Sapporo Shi Chuo Ku, Japan, 064-0919
Actively Recruiting
153
NTT Medical Center Tokyo
Shinagawa-KU, Japan, 141-8625
Not Yet Recruiting
154
JHCO Tokyo Yamate Medical Center
Shinjuku-ku, Japan, 169-0073
Not Yet Recruiting
155
Tokyo Metro Bokutoh Hospital
Sumida-ku, Japan, 130-8575
Not Yet Recruiting
156
National Hospital Organization Shizuoka Medical Center
Sunto-gun, Japan, 411-8611
Actively Recruiting
157
Toyama University Hospital
Toyama, Japan, 930-0194
Actively Recruiting
158
Mie University Hospital
Tsu, Japan, 514-8507
Actively Recruiting
159
Matsushima Hospital
Yokohama, Japan, 220 0041
Not Yet Recruiting
160
Liepaja Regional Hospital
Liepāja, Latvia, LV-3414
Actively Recruiting
161
Pauls Stradins Clinical Univeristy Hospital
Riga, Latvia, LV-1002
Actively Recruiting
162
ManerMed Sp z o.o. Centrum Medyczne ,Medis
Bydgoszcz, Poland, 85-229
Actively Recruiting
163
Centrum Medyczne Kermed Renata Bojata-Bronisz i Ewa Kowalińska Sp.j.
Bydgoszcz, Poland, 85-231
Actively Recruiting
164
Centrum Medyczne Plejady Magdalena Celińska-Löwenhoff, Michał Żołnowski sp.k
Krakow, Poland, 30-363
Actively Recruiting
165
Centrum Nowoczesnych Terapii "Dobry Lekarz" sp. z o. o.
Krakow, Poland, 31-011
Actively Recruiting
166
Topolowa Medicenter Ryszawa & Wspólnicy Sp.j.
Krakow, Poland, 31-506
Actively Recruiting
167
Ip Clinic Sp. Z O. O.
Lodz, Poland, 90-752
Actively Recruiting
168
Med-GASTR SP. Z O.O., SP.K.
Lodz, Poland, 91 034
Actively Recruiting
169
Medrise Sp. z o.o
Lublin, Poland, 20-582
Actively Recruiting
170
Twoja Przychodnia Opolskie Centrum Medyczne
Opole, Poland, 45 819
Actively Recruiting
171
Twoja Przychodnia Pcm
Poznan, Poland, 60-324
Actively Recruiting
172
Endoskopia Sp. z.o.o.
Sopot, Poland, 81-756
Actively Recruiting
173
Gastromed Sp. z o.o.
Torun, Poland, 87-100
Actively Recruiting
174
H-T. Centrum Medyczne-Endoterapia
Tychy, Poland, 43-100
Not Yet Recruiting
175
NZOZ FOR MED sp. z o.o.
Wadowice, Poland, 34-100
Actively Recruiting
176
WIP Warsaw IBD Point Profesor Kierkus
Warsaw, Poland, 04-501
Actively Recruiting
177
Centrum Medyczne Oporów
Wroclaw, Poland, 52-416
Actively Recruiting
178
VISTAMED
Wroclaw, Poland, 53-149
Actively Recruiting
179
Melita Medical
Wroclaw, Poland, 53-611
Actively Recruiting
180
Dr.Carol Davila Emergency University Central Military Hospital
Bucharest, Romania, 010825
Not Yet Recruiting
181
S.C. Centrul Medical Medicum SRL
Bucharest, Romania, 012015
Actively Recruiting
182
Colentina Clinical Hospital
Bucharest, Romania, 020125
Actively Recruiting
183
Emergency University Hospital
Bucharest, Romania, 50098
Actively Recruiting
184
Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
Cluj-Napoca, Romania, 400162
Actively Recruiting
185
Valahia Medical Center SRL
Ploieşti, Romania, 100032
Actively Recruiting
186
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
Timișoara, Romania, 300002
Actively Recruiting
187
Clinical Center " Dr Dragisa Misovic Dedinje"
Belgrade, Serbia, 11000
Actively Recruiting
188
Clinical Hospital Center Bezanijska Kosa
Belgrade, Serbia, 11000
Actively Recruiting
189
Clinical Hospital Center Zvezdara
Belgrade, Serbia, 11000
Actively Recruiting
190
Clinical Hospital Centre Zemun
Belgrade, Serbia, 11000
Not Yet Recruiting
191
Military Medical Academy
Belgrade, Serbia, 11000
Actively Recruiting
192
Clinical Center of Vojvodina
Novi Sad, Serbia, 21000
Actively Recruiting
193
General Hospital Pancevo
Pančevo, Serbia, 26101
Actively Recruiting
194
General Hospital "Djordje Joanovic"
Zrenjanin, Serbia, 23000
Actively Recruiting
195
Centro Medico Teknon - DIGESTIVO
Barcelona, Spain, 8022
Actively Recruiting
196
Hospital General Tomelloso
Ciudad Real, Spain, 13700
Actively Recruiting
197
Hospital Universitario Reina Sofia Comite Etico
Córdoba, Spain, 14004
Actively Recruiting
198
Hospital Universitario Juan Ramon Jimenez
Huelva, Spain, 21005
Actively Recruiting
199
Hospital Universitario de Gran Canaria Doctor Negrín
Las Palmas de GC, Spain, 35019
Actively Recruiting
200
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
201
Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, Spain, 15706
Actively Recruiting
202
Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
203
CEIM Hospital Universitario y Politecnico la Fe
Valencia, Spain, 46026
Actively Recruiting
204
Gazi University Medical Faculty Gazi Hospital
Ankara, Turkey (Türkiye), 6560
Not Yet Recruiting
205
Ege Universitesi Hastanesi
Izmir, Turkey (Türkiye), 35100
Not Yet Recruiting
206
İnönü Üniversitesi Tıp Fakültesi
Malatya, Turkey (Türkiye), 44280
Not Yet Recruiting
207
Mersin University Medical Faculty Hospital
Mersin, Turkey (Türkiye), 33169
Not Yet Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here