Actively Recruiting
Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis
Led by Enveda Therapeutics · Updated on 2026-05-12
60
Participants Needed
20
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about the safety and effectiveness of ENV-294 in adults with moderate to severe atopic dermatitis. The main questions it will answer are: * Is there an impact on the severity and area of atopic dermatitis when participants take ENV-294 * What medical problems do participants have when taking ENV-294 Participants will: * Take drug ENV-294 or a placebo once every day for 12 weeks * Visit the clinic every 2 to 4 weeks for checkups and tests * Keep a diary of their symptoms and when they took their study drug * Return to the clinic for the final study visit at approximately week 16
CONDITIONS
Official Title
Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Have chronic atopic dermatitis diagnosed at least 12 months before the first study visit
- Have moderate to severe atopic dermatitis at screening and baseline, defined by: a vIGA score of 3 or 4, an EASI score of 16 or higher, BSA of 10% or more, and a PP-NRS score of 4 or higher
- Had a poor response or intolerance to topical treatments for atopic dermatitis in the past 6 months
- Use a bland moisturizer at least once daily
You will not qualify if you...
- Have current or recurrent medical conditions that could affect the study drug or assessments
- Have any illness that could impact safety or active infections
- Have ongoing skin conditions or large tattoos that would interfere with clinical assessments
- Have clinically significant skin infection needing treatment
- Have clinically significant abnormal laboratory results at screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
Enveda Investigative Site
Birmingham, Alabama, United States, 35244
Actively Recruiting
2
Enveda Investigative Site
Hot Springs, Arkansas, United States, 71913
Actively Recruiting
3
Enveda Investigative Site
Beverly Hills, California, United States, 90212
Actively Recruiting
4
Enveda Investigative Site
Fremont, California, United States, 94538
Actively Recruiting
5
Enveda Investigative Site
San Diego, California, United States, 92121
Actively Recruiting
6
Enveda Investigative Site
San Diego, California, United States, 92123
Actively Recruiting
7
Enveda Investigative Site
New Albany, Indiana, United States, 47150
Actively Recruiting
8
Enveda Investigative Site
West Lafayette, Indiana, United States, 47906
Actively Recruiting
9
Enveda Investigative Site
Louisville, Kentucky, United States, 40217
Actively Recruiting
10
Enveda Investigative Site
Auburn Hills, Michigan, United States, 48326
Actively Recruiting
11
Enveda Investigative Site
Bay City, Michigan, United States, 48706
Actively Recruiting
12
Enveda Investigative Site
Clinton Township, Michigan, United States, 48038
Actively Recruiting
13
Enveda Investigative Site
Las Vegas, Nevada, United States, 89145
Actively Recruiting
14
Enveda Investigative Site
Canton, Ohio, United States, 44718
Actively Recruiting
15
Enveda Investigative Site
Mayfield Heights, Ohio, United States, 44124
Actively Recruiting
16
Enveda Investigative Site
Camp Hill, Pennsylvania, United States, 17011
Actively Recruiting
17
Enveda Investigative Site
Arlington, Texas, United States, 76011
Actively Recruiting
18
Enveda Investigative Site
Houston, Texas, United States, 77004
Actively Recruiting
19
Enveda Investigative Site
San Antonio, Texas, United States, 78218
Actively Recruiting
20
Enveda Investigative Site
Norfolk, Virginia, United States, 23502
Actively Recruiting
Research Team
C
Clinical Operations
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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