Actively Recruiting
A Study of EP0031 in Patients With Advanced RET-altered Malignancies
Led by Ellipses Pharma · Updated on 2026-02-03
265
Participants Needed
40
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to assess the safety, side effects and effectiveness of EP0031 in patients with advanced RET-altered malignancies (NSCLC)
CONDITIONS
Official Title
A Study of EP0031 in Patients With Advanced RET-altered Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be 18 years of age or older with documented RET-altered cancers
- Patients should be informed and consented about alternative treatment options including approved RET-targeted therapies
- ECOG performance status of 0 or 1 and life expectancy greater than 3 months at screening
- Ability to understand and provide written informed consent and participate in all required evaluations and procedures
- Additional cohort-specific criteria apply
You will not qualify if you...
- Any known major driver gene alterations other than RET
- Spinal cord compression or brain metastases (except stable brain metastases)
- Active infection requiring systemic antibiotic, antifungal, or antiviral medication
- Severe or uncontrolled medical or psychiatric conditions
- Chronic glomerulonephritis or renal transplant
- Active hepatitis B or hepatitis C infection
- Active HIV infection (unless adequate CD4+ count and no AIDS-defining infections in past 12 months)
- Receipt of any strong inhibitor or inducer of CYP3A4
- Impaired liver or kidney function, inadequate bone marrow reserve or organ function
- Clinically important ECG abnormalities or recent serious heart conditions
- Uncontrolled hypertension
- Corneal ulceration at screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
David Geffen School of Medicine at UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
2
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
3
Georgetown University
Washington D.C., District of Columbia, United States, 20057
Actively Recruiting
4
Florida Cancer Specialist
Fort Myers, Florida, United States, 33908
Actively Recruiting
5
RUSH University Medical Center
Chicago, Illinois, United States, 60612
Terminated
6
Northwestern University
Evanston, Illinois, United States, 60208
Actively Recruiting
7
University of Kentucky
Lexington, Kentucky, United States, 40506
Actively Recruiting
8
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
9
Karmanos
Detroit, Michigan, United States, 48201
Terminated
10
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 07920
Actively Recruiting
11
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
12
Providence Portland Medical Centre
Portland, Oregon, United States, 97213
Actively Recruiting
13
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
14
Sarah Cannon
Nashville, Tennessee, United States, 37203
Actively Recruiting
15
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
16
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
17
Washington University
Seattle, Washington, United States, 63130
Actively Recruiting
18
Seattle Cancer Care / Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109
Actively Recruiting
19
Assistance publique - Hôpitaux de Marseille
Marseille, Bouches-du-Rhône, France
Actively Recruiting
20
Center Bergonié
Bordeaux, Gironde, France
Actively Recruiting
21
Institut Gustave-Roussy
Villejuif, Paris, France
Actively Recruiting
22
Centre François Baclesse
Caen, France
Actively Recruiting
23
Centre Léon Bérard
Lyon, France
Actively Recruiting
24
Charité Comprehensive Cancer Center
Berlin, Germany
Actively Recruiting
25
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Actively Recruiting
26
Hospital Universitario de A Coruña
A Coruña, Spain
Actively Recruiting
27
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
28
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, Spain
Actively Recruiting
29
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
30
University Hospital October 12
Madrid, Spain, 28041
Actively Recruiting
31
Hospital Madrid Sanchinarro
Madrid, Spain, 28050
Actively Recruiting
32
Hospital Virgen de la Victoria de Malaga
Málaga, Spain, 29010
Actively Recruiting
33
Tawam Hospital
Al Ain City, Abu Dhabi Emirate, United Arab Emirates
Actively Recruiting
34
Sheik Shakhbout Medical City (SSMC)
Abu Dhabi, United Arab Emirates, 11001
Actively Recruiting
35
Cleveland Clinic Abu Dhabi (CCAD)
Abu Dhabi, United Arab Emirates, 112412
Actively Recruiting
36
University College London Hospital
London, United Kingdom, NW1 2BU
Actively Recruiting
37
Guy's Hospital
London, United Kingdom, SE1 9RT
Actively Recruiting
38
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW36JJ
Actively Recruiting
39
The Christie NHS Foundation Trust - Christie Hospital
Manchester, United Kingdom, M20 4BX
Actively Recruiting
40
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S10 2JF
Actively Recruiting
Research Team
C
Clinical Trials Team
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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