Actively Recruiting
Study for Epidemiology and Characterization of Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leucemia (JMML) in Childhood
Led by University Hospital Freiburg · Updated on 2026-05-04
260
Participants Needed
1
Research Sites
921 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to improve the accuracy of diagnosis for children and adolescents with MDS by a standardized review of morphology and standardized cytogenetic and molecular analysis. The primary objectives of the study are: * To evaluate the frequency of the different subtypes of MDS in childhood and adolescence by a standardized diagnostic approach * To evaluate the frequency of cytogenetic and molecular abnormalities: Specifically using array-CGH to evaluate the frequency of subtle chromosomal imbalances, i.e. gains and losses of defined chromosomal regions, and amplifications. Specifically using mFISH to identify unknown chromosomal aberrations, particularly subtle translocations involving new candidate genes, and to better define chromosomal breakpoints. The secondary objectives of the study are: * To assess survival for children and adolescents with MDS and JMML * To evaluate relapse rate, morbidity and mortality in children with MDS and JMML treated by HSCT
CONDITIONS
Official Title
Study for Epidemiology and Characterization of Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leucemia (JMML) in Childhood
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent by the caretakers and whenever possible the patient's assent.
- Confirmed diagnosis of MDS or JMML (morphology, cytogenetics).
- Myeloid leukemia of Down syndrome in patients aged over 6 years.
- Age less than 18 years.
You will not qualify if you...
- Denied informed consent and/or assent by caretakers or patient.
- Myeloid leukemia of Down syndrome in patients under 6 years.
- Participation in another study within the last 4 weeks (except therapy optimizing studies in cancer or bone marrow failure disorders and diagnostic studies).
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital of Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106
Actively Recruiting
Research Team
C
Charlotte M. Niemeyer, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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