Actively Recruiting
A Study to Evaluate Adrixetinib (Q702) in Adults With Active Chronic Graft-Versus-Host Disease
Led by Qurient Co., Ltd. · Updated on 2025-12-30
18
Participants Needed
8
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Open-label, dose escalation study to evaluate safety, tolerability pharmacokinetic and pharmacodynamic activity, and efficacy of Adrixetinib (Q702) in subjects with relapsed or refractory active chronic graft-versus-host disease (cGVHD).
CONDITIONS
Official Title
A Study to Evaluate Adrixetinib (Q702) in Adults With Active Chronic Graft-Versus-Host Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults who have received an allogeneic hematopoietic stem cell transplant with moderate or severe active chronic graft-versus-host disease requiring systemic immune suppression
- Have relapsed or refractory active chronic graft-versus-host disease progressing after all standard treatments
- Documented progressive disease by NIH 2014 consensus criteria or active symptomatic cGVHD needing new systemic therapy
- Adequate organ and bone marrow function
- Karnofsky Performance Scale score of 60 or higher
You will not qualify if you...
- Prior treatment with CSF1R inhibitor therapy after allogeneic transplant
- Evidence of relapse of the original cancer by histologic, cytogenetic, molecular, hematologic, or mixed means
- Diagnosis of another malignancy (other than the one treated by transplant) within 3 years before enrollment
- Female participants who are pregnant or breastfeeding
- Active, uncontrolled bacterial, viral, or fungal infections requiring systemic treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Hospital Clinic de Barcelona
Barcelona, Spain
Actively Recruiting
2
Hospital General Universitario Gregorio Maranon
Madrid, Spain
Actively Recruiting
3
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain
Actively Recruiting
4
Hospital Universitario Virgen de la Arrixaca
Murcia, Spain
Actively Recruiting
5
Clinica Universidad de Navarra
Pamplona, Spain
Actively Recruiting
6
Hospital Universitario Marques de Valdecilla
Santander, Spain
Actively Recruiting
7
Hospital Universitario Virgen del Rocio
Seville, Spain
Actively Recruiting
8
Instituto de Investigacion Sanitaria
Valencia, Spain
Actively Recruiting
Research Team
Q
Qurient Clinical Trial Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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