Actively Recruiting
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
Led by Alnylam Pharmaceuticals · Updated on 2026-05-14
93
Participants Needed
3
Research Sites
126 weeks
Total Duration
On this page
Sponsors
A
Alnylam Pharmaceuticals
Lead Sponsor
H
Hoffmann-La Roche
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.
CONDITIONS
Official Title
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult participants with mean seated office systolic blood pressure (SBP) of at least 130 mmHg and no more than 170 mmHg (Part A)
- Adult participants with mean seated office SBP of at least 140 mmHg and no more than 170 mmHg (Part B)
- Participants either not taking antihypertensive medication or on stable therapy with up to 2 antihypertensive medications (Part A)
- Participants who have discontinued all prior antihypertensive medication except calcium channel blockers and/or thiazide/thiazide-like diuretics for at least 3 weeks (Part B)
You will not qualify if you...
- Known secondary hypertension
- Serum potassium level more than 5 mmol/L
- Estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m^2
- Other protocol defined exclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Clinical Trial Site
Lake Forest, California, United States, 92630
Actively Recruiting
2
Clinical Trial Site
Tampa, Florida, United States, 33602
Actively Recruiting
3
Clinical Trial Site
Savannah, Georgia, United States, 31401
Actively Recruiting
Research Team
A
Alnylam Clinical Trial Information Line
CONTACT
A
Alnylam Clinical Trial Information Line
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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