Actively Recruiting

Age: 0 - 10Years
All Genders
NCT04509050

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

Led by Sonya Heltshe · Updated on 2024-08-12

210

Participants Needed

35

Research Sites

471 weeks

Total Duration

On this page

Sponsors

S

Sonya Heltshe

Lead Sponsor

C

Cystic Fibrosis Foundation

Collaborating Sponsor

AI-Summary

What this Trial Is About

This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).

CONDITIONS

Official Title

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

Who Can Participate

Age: 0 - 10Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Part A: Less than 10 years of age at the first study visit
  • Part A: Documentation of a cystic fibrosis diagnosis
  • Part B: Participated in Part A OR less than 7 years of age at the first study visit
  • Part B: Documentation of a cystic fibrosis diagnosis
  • Part B: CFTR mutations consistent with FDA labeled indication of highly effective modulator therapy (ivacaftor or elexacaftor/tezacaftor/ivacaftor)
  • Part B: Physician intent to prescribe ivacaftor or elexacaftor/tezacaftor/ivacaftor
Not Eligible

You will not qualify if you...

  • Use of an investigational drug within 28 days prior to and including the first study visit
  • Use of ivacaftor or elexacaftor/tezacaftor/ivacaftor within the 28 days prior to and including the first study visit
  • Use of chronic oral corticosteroids within the 28 days prior to and including the first study visit

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 35 locations

1

The Children's Hospital Alabama, University of Alabama at Birmingham

Birmingham, Alabama, United States, 35233

Actively Recruiting

2

Stanford University Medical Center

Palo Alto, California, United States, 94304

Actively Recruiting

3

Children's Hospital Colorado

Aurora, Colorado, United States, 80045

Actively Recruiting

4

Nemours Children's Clinic

Jacksonville, Florida, United States, 32207

Actively Recruiting

5

University of Miami

Miami, Florida, United States, 33136

Actively Recruiting

6

The Nemours Children's Clinic - Orlando

Orlando, Florida, United States, 32827

Actively Recruiting

7

Riley Hospital for Children

Indianapolis, Indiana, United States, 46202

Actively Recruiting

8

University of Iowa

Iowa City, Iowa, United States, 52242

Actively Recruiting

9

University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

Actively Recruiting

10

Boston Children's Hospital

Boston, Massachusetts, United States, 02115

Actively Recruiting

11

University of Michigan, Michigan Medicine

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

12

Helen DeVos Children's Hospital

Grand Rapids, Michigan, United States, 49503

Actively Recruiting

13

Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, United States, 55404

Actively Recruiting

14

The Minnesota Cystic Fibrosis Center

Minneapolis, Minnesota, United States, 55455

Actively Recruiting

15

Children's Mercy Kansas City

Kansas City, Missouri, United States, 64108

Actively Recruiting

16

St. Louis Children's Hospital

St Louis, Missouri, United States, 63110

Actively Recruiting

17

The Cystic Fibrosis Center of Western New York

Buffalo, New York, United States, 14203

Actively Recruiting

18

Children's Hospital of New York

New York, New York, United States, 10032

Actively Recruiting

19

SUNY Upstate Medical University

Syracuse, New York, United States, 13210

Actively Recruiting

20

New York Medical College at Westchester Medical Center

Valhalla, New York, United States, 10595

Actively Recruiting

21

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States, 45229

Actively Recruiting

22

Nationwide Children's Hospital

Columbus, Ohio, United States, 43205

Actively Recruiting

23

Oklahoma Cystic Fibrosis Center

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

24

Oregon Health Sciences University

Portland, Oregon, United States, 97239

Actively Recruiting

25

Hershey Medical Center Pennsylvania State University

Hershey, Pennsylvania, United States, 17033

Actively Recruiting

26

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

27

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, United States, 15224

Actively Recruiting

28

University of Texas Southwestern / Children's Health

Dallas, Texas, United States, 75207

Actively Recruiting

29

Cook Children's Medical Center

Fort Worth, Texas, United States, 76104

Actively Recruiting

30

Baylor College of Medicine

Houston, Texas, United States, 77030

Actively Recruiting

31

Primary Children's Cystic Fibrosis Center

Salt Lake City, Utah, United States, 84113

Actively Recruiting

32

Vermont Children's Hospital

Burlington, Vermont, United States, 05401

Actively Recruiting

33

University of Virginia

Charlottesville, Virginia, United States, 22903

Actively Recruiting

34

Seattle Children's Hospital

Seattle, Washington, United States, 98105

Actively Recruiting

35

University of Wisconsin

Madison, Wisconsin, United States, 53792

Actively Recruiting

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Research Team

R

Rachael Buckingham

CONTACT

A

Anna Mead

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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