Actively Recruiting
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
Led by Incyte Corporation · Updated on 2026-05-08
588
Participants Needed
212
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy and safety of standard chemotherapy with or without INCB161734 in participants with metastatic pancreatic ductal adenocarcinoma (PDAC).
CONDITIONS
Official Title
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed metastatic PDAC with a KRAS G12D mutation
- No prior systemic treatment in the metastatic setting
- ECOG Performance status 0-1
- Adequate organ function
You will not qualify if you...
- Prior treatment with any KRAS inhibitor
- Chronic or current active infection requiring systemic treatment within 1 week prior to the first dose of study drug
- Known active CNS metastases
- Other protocol-defined inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 212 locations
1
Investigative Site US058
Birmingham, Alabama, United States, 35233
Not Yet Recruiting
2
Investigative Site US016
Anchorage, Alaska, United States, 99508
Actively Recruiting
3
Investigative Site US026
Chandler, Arizona, United States, 85224
Not Yet Recruiting
4
Investigative Site US045
Tucson, Arizona, United States, 85719
Not Yet Recruiting
5
Investigative Site US051
Duarte, California, United States, 91010
Not Yet Recruiting
6
Investigative Site US048
Fountain Valley, California, United States, 92708
Not Yet Recruiting
7
Investigative Site US049
Irvine, California, United States, 92612
Not Yet Recruiting
8
Investigative Site US054
La Jolla, California, United States, 92093
Not Yet Recruiting
9
Investigative Site US027
Los Angeles, California, United States, 90027
Not Yet Recruiting
10
Investigative Site US036
Los Angeles, California, United States, 90033
Not Yet Recruiting
11
Investigative Site US034
San Francisco, California, United States, 94143
Not Yet Recruiting
12
Investigative Site US001
Santa Monica, California, United States, 90404
Not Yet Recruiting
13
Investigative Site US071
Denver, Colorado, United States, 80218
Actively Recruiting
14
Investigative Site US013
Washington D.C., District of Columbia, United States, 20007
Not Yet Recruiting
15
Investigative Site US046
Washington D.C., District of Columbia, United States, 20016
Not Yet Recruiting
16
Investigative Site US072
Fort Myers, Florida, United States, 33901
Actively Recruiting
17
Investigative Site US075
Miami, Florida, United States, 33136
Not Yet Recruiting
18
Investigative Site US074
St. Petersburg, Florida, United States, 33701-4553
Actively Recruiting
19
Investigative Site US073
West Palm Beach, Florida, United States, 33401
Actively Recruiting
20
Investigative Site US023
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
21
Investigative Site US079
Chicago, Illinois, United States, 60637
Not Yet Recruiting
22
Investigative Site US030
Evanston, Illinois, United States, 60201
Not Yet Recruiting
23
Investigative Site US005
Naperville, Illinois, United States, 60540
Not Yet Recruiting
24
Investigative Site US009
Springfield, Illinois, United States, 62702
Not Yet Recruiting
25
Investigative Site US021
Indianapolis, Indiana, United States, 46250
Not Yet Recruiting
26
Investigative Site US007
New Orleans, Louisiana, United States, 70121
Not Yet Recruiting
27
Investigative Site US022
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
28
Investigative Site US006
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
29
Investigative Site US010
Detroit, Michigan, United States, 48201
Not Yet Recruiting
30
Investigative Site US078
Grand Rapids, Michigan, United States, 49546
Not Yet Recruiting
31
Investigative Site US012
Ypsilanti, Michigan, United States, 48197
Not Yet Recruiting
32
Investigative Site US066
Maple Grove, Minnesota, United States, 55369
Not Yet Recruiting
33
Investigative Site US047
Hattiesburg, Mississippi, United States, 39401
Not Yet Recruiting
34
Investigative Site US077
Hackensack, New Jersey, United States, 07601
Not Yet Recruiting
35
Investigative Site US017
Morristown, New Jersey, United States, 07960
Not Yet Recruiting
36
Investigative Site US059
Lake Success, New York, United States, 11042
Actively Recruiting
37
Investigative Site US031
New York, New York, United States, 10016
Not Yet Recruiting
38
Investigative Site US041
New York, New York, United States, 10029
Not Yet Recruiting
39
Investigative Site US004
New York, New York, United States, 10032
Not Yet Recruiting
40
Investigative Site US003
New York, New York, United States, 10065
Not Yet Recruiting
41
Investigative Site US029
The Bronx, New York, United States, 10461
Not Yet Recruiting
42
Investigative Site US035
Chapel Hill, North Carolina, United States, 27514
Not Yet Recruiting
43
Investigative Site US050
Cleveland, Ohio, United States, 44106
Not Yet Recruiting
44
Investigative Site US020
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
45
Investigative Site US033
Columbus, Ohio, United States, 43210
Not Yet Recruiting
46
Investigative Site US042
Portland, Oregon, United States, 97239
Not Yet Recruiting
47
Investigative Site US008
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
48
Investigative Site US043
Philadelphia, Pennsylvania, United States, 19107
Not Yet Recruiting
49
Investigative Site US056
Pittsburgh, Pennsylvania, United States, 15212
Not Yet Recruiting
50
Investigative Site US055
Sioux Falls, South Dakota, United States, 57105
Not Yet Recruiting
51
Investigative Site US039
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
52
Investigative Site US060
Nashville, Tennessee, United States, 37203
Actively Recruiting
53
Investigative Site US070
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
54
Investigative Site US067
Dallas, Texas, United States, 75246
Actively Recruiting
55
Investigative Site US062
Denison, Texas, United States, 75020
Actively Recruiting
56
Investigative Site US011
Houston, Texas, United States, 77030
Not Yet Recruiting
57
Investigative Site US018
Houston, Texas, United States, 77030
Not Yet Recruiting
58
Investigative Site US063
San Antonio, Texas, United States, 78240
Actively Recruiting
59
Investigative Site US053
Salt Lake City, Utah, United States, 84112
Not Yet Recruiting
60
Investigative Site US076
Charlottesville, Virginia, United States, 22903
Not Yet Recruiting
61
Investigative Site US057
Fairfax, Virginia, United States, 22031
Not Yet Recruiting
62
Investigative Site US065
Fairfax, Virginia, United States, 22031
Not Yet Recruiting
63
Investigative Site US064
Salem, Virginia, United States, 24153
Actively Recruiting
64
Investigative Site US032
Seattle, Washington, United States, 98122
Not Yet Recruiting
65
Investigative Site US044
Madison, Wisconsin, United States, 53706
Not Yet Recruiting
66
Investigative Site AU007
Liverpool, New South Wales, Australia, 02170
Not Yet Recruiting
67
Investigative Site AU003
Wollongong, New South Wales, Australia, 02500
Not Yet Recruiting
68
Investigative Site AU006
Woodville South, South Australia, Australia, 05011
Not Yet Recruiting
69
Investigative Site AU005
Box Hill, Victoria, Australia, 03128
Not Yet Recruiting
70
Investigative Site AU004
Melbourne, Victoria, Australia, 03000
Not Yet Recruiting
71
Investigative Site AU001
Melbourne, Victoria, Australia, 03004
Not Yet Recruiting
72
Investigative Site AU002
Canberra, Australia, 02605
Not Yet Recruiting
73
Investigative Site AU008
Perth, Australia, 06009
Not Yet Recruiting
74
Investigative Site AT002
Innsbruck, Austria, 06020
Not Yet Recruiting
75
Investigative Site AT004
Linz, Austria, 04010
Not Yet Recruiting
76
Investigative Site AT003
Salzburg, Austria, 05020
Not Yet Recruiting
77
Investigative Site AT001
Vienna, Austria, 01090
Not Yet Recruiting
78
Investigative Site BE008
Anderlecht, Belgium, 01070
Not Yet Recruiting
79
Investigative Site BE003
Brussels, Belgium, 01090
Not Yet Recruiting
80
Investigative Site BE009
Brussels, Belgium, 01200
Not Yet Recruiting
81
Investigative Site BE001
Edegem, Belgium, 02650
Not Yet Recruiting
82
Investigative Site BE005
Ghent, Belgium, 09000
Not Yet Recruiting
83
Investigative Site BE007
Gilly, Belgium, 06060
Not Yet Recruiting
84
Investigative Site BE004
Leuven, Belgium, 03000
Not Yet Recruiting
85
Investigative Site BE006
Liège, Belgium, 04000
Not Yet Recruiting
86
Investigative Site BE002
Yvoir, Belgium, 05530
Not Yet Recruiting
87
Investigative Site CA001
Toronto, Ontario, Canada, M5G 2M9
Not Yet Recruiting
88
Investigative Site CA005
Laval, Quebec, Canada, H7M 3L9
Not Yet Recruiting
89
Investigative Site CA006
Montreal, Quebec, Canada, H4A 3J1
Not Yet Recruiting
90
Investigative Site CA004
Québec, Quebec, Canada, G1J 1Z4
Not Yet Recruiting
91
Investigative Site DK006
Aalborg, Denmark, 09000
Not Yet Recruiting
92
Investigative Site DK005
Århus N, Denmark, 08200
Not Yet Recruiting
93
Investigative Site DK001
Herlev, Denmark, 02730
Not Yet Recruiting
94
Investigative Site DK004
Odense C, Denmark, 05000
Not Yet Recruiting
95
Investigative Site DK003
Roskilde, Denmark, 04000
Not Yet Recruiting
96
Investigative Site DK002
Vejle, Denmark, 07100
Not Yet Recruiting
97
Investigative Site FI001
Helsinki, Finland, 00029
Not Yet Recruiting
98
Investigative Site FI003
Tampere, Finland, 33521
Not Yet Recruiting
99
Investigative Site FI002
Turku, Finland, 20521
Not Yet Recruiting
100
Investigative Site FR013
Brest, France, 29200
Not Yet Recruiting
101
Investigative Site FR012
Chambray-lès-Tours, France, 37170
Not Yet Recruiting
102
Investigative Site FR014
Dijon, France, 21000
Not Yet Recruiting
103
Investigative Site FR002
Lille, France, 59037
Not Yet Recruiting
104
Investigative Site FR011
Lyon, France, 69008
Not Yet Recruiting
105
Investigative Site FR016
Lyon, France, 69373
Not Yet Recruiting
106
Investigative Site FR006
Marseille, France, 13385
Not Yet Recruiting
107
Investigative Site FR015
Montpellier, France, 34298
Not Yet Recruiting
108
Investigative Site FR003
Paris, France, 75013
Not Yet Recruiting
109
Investigative Site FR009
Paris, France, 75015
Not Yet Recruiting
110
Investigative Site FR004
Pessac, France, 33604
Not Yet Recruiting
111
Investigative Site FR008
Poitiers, France, 86021
Not Yet Recruiting
112
Investigative Site FR010
Reims, France, 51100
Not Yet Recruiting
113
Investigative Site FR005
Rennes, France, 35042
Not Yet Recruiting
114
Investigative Site FR007
Toulouse, France, 31059
Not Yet Recruiting
115
Investigative Site FR001
Villejuif, France, 94805
Not Yet Recruiting
116
Investigative Site DE018
Berlin, Germany, 10365
Not Yet Recruiting
117
Investigative Site DE020
Berlin, Germany, 13353
Not Yet Recruiting
118
Investigative Site DE003
Bochum, Germany, 44791
Not Yet Recruiting
119
Investigative Site DE019
Bonn, Germany, 53127
Not Yet Recruiting
120
Investigative Site DE008
Cologne, Germany, 50937
Not Yet Recruiting
121
Investigative Site DE001
Dresden, Germany, 01307
Not Yet Recruiting
122
Investigative Site DE013
Düsseldorf, Germany, 40225
Not Yet Recruiting
123
Investigative Site DE004
Essen, Germany, 45147
Not Yet Recruiting
124
Investigative Site DE005
Frankfurt, Germany, 60488
Not Yet Recruiting
125
Investigative Site DE016
Freiburg im Breisgau, Germany, 79106
Not Yet Recruiting
126
Investigative Site DE017
Göttingen, Germany, 37075
Not Yet Recruiting
127
Investigative Site DE002
Halle, Germany, 06120
Not Yet Recruiting
128
Investigative Site DE007
Hamburg, Germany, 20246
Not Yet Recruiting
129
Investigative Site DE006
Hamburg, Germany, 22763
Not Yet Recruiting
130
Investigative Site DE009
Leipzig, Germany, 04103
Not Yet Recruiting
131
Investigative Site DE015
Munich, Germany, 81377
Not Yet Recruiting
132
Investigative Site DE014
München, Germany, 81737
Not Yet Recruiting
133
Investigative Site DE010
Nuremberg, Germany, 90419
Not Yet Recruiting
134
Investigative Site DE011
Ulm, Germany, 89081
Not Yet Recruiting
135
Investigative Site IT002
Bologna, Italy, 40138
Not Yet Recruiting
136
Investigative Site IT010
Brescia, Italy, 25124
Not Yet Recruiting
137
Investigative Site IT009
Candiolo, Italy, 10060
Not Yet Recruiting
138
Investigative Site IT012
Foggia, Italy, 71122
Not Yet Recruiting
139
Investigative Site IT006
Milan, Italy, 20132
Not Yet Recruiting
140
Investigative Site IT008
Milan, Italy, 20133
Not Yet Recruiting
141
Investigative Site IT011
Naples, Italy, 80131
Not Yet Recruiting
142
Investigative Site IT003
Pisa, Italy, 56126
Not Yet Recruiting
143
Investigative Site IT004
Roma, Italy, 00152
Not Yet Recruiting
144
Investigative Site IT005
Rome, Italy, 00138
Not Yet Recruiting
145
Investigative Site IT001
Rozzano, Italy, 20089
Not Yet Recruiting
146
Investigative Site IT007
Verona, Italy, 37134
Not Yet Recruiting
147
Investigative Site JP002
Kashiwa-shi, Japan, 277-8577
Not Yet Recruiting
148
Investigative Site JP003
Kōtoku, Japan, 135-8550
Not Yet Recruiting
149
Investigative Site JP007
Mitaka-shi, Japan, 181-8611
Not Yet Recruiting
150
Investigative Site JP004
Osaka, Japan, 541-8567
Not Yet Recruiting
151
Investigative Site JP009
Shinjuku-ku, Japan, 160-0023
Not Yet Recruiting
152
Investigative Site JP006
Toyama, Japan, 930-0194
Not Yet Recruiting
153
Investigative Site JP008
Wakayama, Japan, 641-8510
Not Yet Recruiting
154
Investigative Site JP001
Yokohama, Japan, 241-8515
Not Yet Recruiting
155
Investigative Site NL001
Amsterdam, Netherlands, 1081 HV
Not Yet Recruiting
156
Investigative Site NL007
Eindhoven, Netherlands, 5623 EJ
Not Yet Recruiting
157
Investigative Site NL005
Groningen, Netherlands, 9700 RB
Not Yet Recruiting
158
Investigative Site NL003
Maastricht, Netherlands, 6202 AZ
Not Yet Recruiting
159
Investigative Site NL006
Nieuwegein, Netherlands, 3430 EM
Not Yet Recruiting
160
Investigative Site NO002
Bergen, Norway, 05021
Not Yet Recruiting
161
Investigative Site NO001
Oslo, Norway, 00379
Not Yet Recruiting
162
Investigative Site NO005
Stavanger, Norway, 04011
Not Yet Recruiting
163
Investigative Site NO003
Trondheim, Norway, 07030
Not Yet Recruiting
164
Investigative Site PL008
Gdansk, Poland, 80-214
Not Yet Recruiting
165
Investigative Site PL003
Krakow, Poland, 31-501
Not Yet Recruiting
166
Investigative Site PL007
Warsaw, Poland, 01-748
Not Yet Recruiting
167
Investigative Site PL001
Warsaw, Poland, 02-034
Not Yet Recruiting
168
Investigative Site PL002
Warsaw, Poland, 02-507
Not Yet Recruiting
169
Investigative Site PL004
Wroclaw, Poland, 53-439
Not Yet Recruiting
170
Investigative Site PR001
Dorado, Puerto Rico, 00646
Actively Recruiting
171
Investigative Site KR004
Goyang-si, South Korea, 10408
Not Yet Recruiting
172
Investigative Site KR005
Seongnam, South Korea, 13620
Not Yet Recruiting
173
Investigative Site KR007
Seongnam-si, South Korea, 13496
Not Yet Recruiting
174
Investigative Site KR002
Seoul, South Korea, 03080
Not Yet Recruiting
175
Investigative Site KR006
Seoul, South Korea, 03722
Not Yet Recruiting
176
Investigative Site KR001
Seoul, South Korea, 05505
Not Yet Recruiting
177
Investigative Site KR003
Seoul, South Korea, 06351
Not Yet Recruiting
178
Investigative Site KR008
Seoul, South Korea, 06591
Not Yet Recruiting
179
Investigative Site ES011
Badalona, Spain, 08916
Not Yet Recruiting
180
Investigative Site ES003
Barcelona, Spain, 08035
Not Yet Recruiting
181
Investigative Site ES002
Barcelona, Spain, 08036
Not Yet Recruiting
182
Investigative Site ES014
Las Palmas de Gran Canaria, Spain, 35016
Not Yet Recruiting
183
Investigative Site ES016
Madrid, Spain, 28007
Not Yet Recruiting
184
Investigative Site ES006
Madrid, Spain, 28034
Not Yet Recruiting
185
Investigative Site ES007
Madrid, Spain, 28040
Not Yet Recruiting
186
Investigative Site ES012
Madrid, Spain, 28040
Not Yet Recruiting
187
Investigative Site ES008
Madrid, Spain, 28041
Not Yet Recruiting
188
Investigative Site ES013
Madrid, Spain, 28050
Not Yet Recruiting
189
Investigative Site ES005
Palma de Mallorca, Spain, 07120
Not Yet Recruiting
190
Investigative Site ES009
Santander, Spain, 39012
Not Yet Recruiting
191
Investigative Site ES010
Seville, Spain, 41009
Not Yet Recruiting
192
Investigative Site ES015
Valencia, Spain, 46009
Not Yet Recruiting
193
Investigative Site ES017
Valencia, Spain, 46010
Not Yet Recruiting
194
Investigative Site ES001
Valencia, Spain, 46014
Not Yet Recruiting
195
Investigative Site ES004
Zaragoza, Spain, 50009
Not Yet Recruiting
196
Investigative Site SE003
Linköping, Sweden, 58185
Not Yet Recruiting
197
Investigative Site SE001
Malmö, Sweden, 21428
Not Yet Recruiting
198
Investigative Site SE002
Solna, Sweden, 171 76
Not Yet Recruiting
199
Investigative Site CH005
Basel, Switzerland, 04058
Not Yet Recruiting
200
Investigative Site CH003
Bern, Switzerland, 03010
Not Yet Recruiting
201
Investigative Site CH004
Geneva, Switzerland, 01205
Not Yet Recruiting
202
Investigative Site CH002
Lausanne, Switzerland, 01011
Not Yet Recruiting
203
Investigative Site CH001
Zurich, Switzerland, 08091
Not Yet Recruiting
204
Investigative Site GB008
Dundee, United Kingdom, DD1 9SY
Not Yet Recruiting
205
Investigative Site GB011
Guildford, United Kingdom, GU2 7XX
Not Yet Recruiting
206
Investigative Site GB002
Headington, United Kingdom, OX3 7LE
Not Yet Recruiting
207
Investigative Site GB001
Leeds, United Kingdom, LS9 7TF
Not Yet Recruiting
208
Investigative Site GB009
London, United Kingdom, EC1A 7BE
Not Yet Recruiting
209
Investigative Site GB004
London, United Kingdom, NW3 2QG
Not Yet Recruiting
210
Investigative Site GB003
Manchester, United Kingdom, M20 4BX
Not Yet Recruiting
211
Investigative Site GB010
Northwood, United Kingdom, HA6 2RN
Not Yet Recruiting
212
Investigative Site GB005
Norwich, United Kingdom, NR4 7UY
Not Yet Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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