Actively Recruiting
Study to Evaluate the Effects of AV-001 on HD-induced Brain Injury.
Led by London Health Sciences Centre Research Institute · Updated on 2026-04-17
60
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute
Lead Sponsor
V
Vasomune Therapeutics, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cognitive decline is increasingly recognized among patients receiving maintenance hemodialysis (HD). This can include trouble remembering, slower thinking or mentally feeling foggy. This research is being done to determine if a new medication (AV-001) can protect the brain from injury caused by hemodialysis by strengthening blood vessels in the brain and reducing inflammation. If successful, this research could lead to better protection for the brains of people undergoing regular dialysis, potentially reducing the risk of cognitive decline and stroke.
CONDITIONS
Official Title
Study to Evaluate the Effects of AV-001 on HD-induced Brain Injury.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- Male and non-pregnant female patients over 18 years old
- Receiving hemodialysis for at least 3 months
- On a thrice weekly hemodialysis schedule
You will not qualify if you...
- Receiving hemodialysis for less than 90 days
- Contraindication to MRI
- Severe cognitive impairment (MoCA score below 18) or diagnosed dementia
- History of clinical stroke
- Pregnancy, breastfeeding, or planning pregnancy
- Intradialytic hypotension event in the past month defined as a drop in systolic blood pressure of 40 mmHg or more with symptoms requiring intervention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
J
Jarrin D Penny, PhD, RN
CONTACT
K
Kathy Koyle
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
3
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