Actively Recruiting
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery
Led by Nantes University Hospital · Updated on 2025-11-14
278
Participants Needed
4
Research Sites
404 weeks
Total Duration
On this page
Sponsors
N
Nantes University Hospital
Lead Sponsor
C
Centre de Recherche en Nutrition Humaine Ouest (CRNH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of the numerical pain rating scale in the 72 hours post-surgery.
CONDITIONS
Official Title
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (over 18 years old)
- Scheduled for a major abdominal surgery as a second procedure: eventration cure and restoration of digestive continuity
- Planned use of a patient-controlled morphine pump or oral opioids after surgery
- Ability to attend follow-up visits for up to 7 months (including 1 and 6 months post-surgery if needed)
- Written informed consent provided
- Affiliated with social security
You will not qualify if you...
- Pregnant women
- Minors, adults under guardianship, or those with legal protection
- Undergoing oncological surgery
- Surgery not considered painful (such as cholecystectomy, hernia, thyroidectomy, bariatric surgery)
- Drug addiction or opioid dependency
- Chronic pain lasting more than 3 months
- Residents of nursing or convalescence homes
- Planned hospitalization within 7 days before surgery
- Severe undernutrition as defined by specific criteria
- Refusal to change eating habits
- Unable to eat by mouth before surgery
- Unable to report or express pain
- Severe psychiatric disorders
- Unable to understand the protocol or provide informed consent
AI-Screening
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Trial Site Locations
Total: 4 locations
1
CHRU Brest La Cavale Blanche
Brest, France
Actively Recruiting
2
Hôpital Louis Mourier from Ap-HP
Colombes, France, 92700
Actively Recruiting
3
CHD Vendée
La Roche-sur-Yon, France
Actively Recruiting
4
CHU Nantes Hôtel Dieu
Nantes, France
Actively Recruiting
Research Team
C
Claire Blanchard, MD-PhD
CONTACT
L
Laetitia Berly
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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