Actively Recruiting
A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures
Led by Jazz Pharmaceuticals · Updated on 2026-05-07
100
Participants Needed
24
Research Sites
104 weeks
Total Duration
On this page
Sponsors
J
Jazz Pharmaceuticals
Lead Sponsor
J
Jazz Pharmaceuticals Research UK Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cannabidiol oral solution (CBD-OS) is approved in the US for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or Tuberous sclerosis complex (TSC) in patients 1 year of age and older. This study will assess the efficacy and safety of CBD-OS in participants aged 12 to 75 years for the treatment of focal-onset seizures (FOS).
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented diagnosis of focal epilepsy with typical EEG findings or normal EEG
- Currently treated with 1 to 4 antiseizure medications on a stable regimen
- Aged 12 to 75 years old at screening
You will not qualify if you...
- Diagnosis of non-epileptic seizures or events that affect efficacy assessment
- Unstable medical conditions other than epilepsy
- History or risk of suicidal behavior or active suicidal thoughts
- Known or suspected allergy to cannabinoids or excipients like sesame oil
- Current or recent (within 28 days) treatment with Epidiolex
- Use of recreational or medicinal cannabis or cannabinoid products within 28 days prior to screening or unwillingness to abstain during the study
- Only nonmotor focal aware seizures or primary generalized epilepsies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Banner University Medical Center-Phoenix
Phoenix, Arizona, United States, 85006
Not Yet Recruiting
2
UC San Diego
La Jolla, California, United States, 92037-1300
Actively Recruiting
3
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
4
University of South Florida
Tampa, Florida, United States, 33606
Not Yet Recruiting
5
Emory University
Atlanta, Georgia, United States, 30329
Actively Recruiting
6
Savannah Neurology Specialists
Savannah, Georgia, United States, 31406
Actively Recruiting
7
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
8
Mid-Atlantic Epilepsy and Sleep Center
Bethesda, Maryland, United States, 20817
Actively Recruiting
9
Wayne State University
Detroit, Michigan, United States, 48201
Not Yet Recruiting
10
Corewell Health
Grand Rapids, Michigan, United States, 49503
Not Yet Recruiting
11
Hackensack Meridian Neuroscience Institute at JFK University Medical Center
Edison, New Jersey, United States, 08820
Not Yet Recruiting
12
Saint Peter's University Hospital
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
13
Boston Children's Health Physicians
Hawthorne, New York, United States, 10532
Actively Recruiting
14
Onsite Clinical Solutions
Charlotte, North Carolina, United States, 28211
Actively Recruiting
15
Velocity Clinical Research at Raleigh Neurology
Raleigh, North Carolina, United States, 27607
Actively Recruiting
16
Cincinnati Children's Hospital
Cincinnati, Ohio, United States, 45229
Not Yet Recruiting
17
University of Cincinnati, Gardner Neuroscience Institute
Cincinnati, Ohio, United States, 45267-0525
Not Yet Recruiting
18
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
19
Le Bonheur Children's Hospital
Memphis, Tennessee, United States, 38103
Actively Recruiting
20
Child Neurology & Consultants of Austin
Austin, Texas, United States, 78757
Actively Recruiting
21
ANESC Research
El Paso, Texas, United States, 79912
Actively Recruiting
22
Intermountain Health
Murray, Utah, United States, 84107
Actively Recruiting
23
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
24
William S Middleton Memorial Veterans Hospital
Madison, Wisconsin, United States, 53705
Not Yet Recruiting
Research Team
C
Clinical Trial Disclosure & Transparency
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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