Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06065748

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Led by Hoffmann-La Roche · Updated on 2026-05-05

1050

Participants Needed

351

Research Sites

270 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib), in participants with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer who have developed resistance to adjuvant endocrine therapy.

CONDITIONS

Official Title

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Locally advanced or metastatic adenocarcinoma of the breast, not amenable to treatment with curative intent
  • Documented estrogen receptor-positive (ER+), HER2-negative (HER2-) tumor assessed locally on the most recent tumor biopsy (or an archived tumor sample if a recent tumor sample is not available for testing)
  • Confirmed ESR1 mutation status (ESR1m versus ESR1nmd) in baseline circulating tumor DNA (ctDNA) through central laboratory testing
  • Resistance to prior adjuvant endocrine therapy (ET), which is defined as having relapsed with prior standard adjuvant ET, on-treatment after >/=12 months or off-treatment within 12 months of completion. Prior use of adjuvant CDK4/6i is allowed (if relapse occurred >/=12 months since completion).
  • No prior systemic anti-cancer therapy for advanced disease
  • Measurable disease as defined per RECIST v.1.1 or non-measurable (including bone-only) disease
  • Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-1
  • For pre/perimenopausal women and for men: willing to undergo and maintain treatment with approved LHRH agonist therapy (as per local guidelines) for the duration of study treatment
Not Eligible

You will not qualify if you...

  • Prior systemic therapy (e.g., prior chemotherapy, immunotherapy, or biologic therapy) for locally advanced unresectable or metastatic breast cancer
  • Prior treatment with another SERD (e.g., fulvestrant, oral SERDs) or novel ER-targeting agents
  • Advanced, symptomatic, visceral spread that is at risk of life-threatening complications in the short term
  • Active cardiac disease or history of cardiac dysfunction
  • Clinically significant history of liver disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 351 locations

1

Southern Cancer Center

Daphne, Alabama, United States, 36526

Actively Recruiting

2

Sutter Auburn Faith Hospital

Auburn, California, United States, 95602

Withdrawn

3

La Hematology Oncology Medical Group

Glendale, California, United States, 91260

Actively Recruiting

4

Marin Cancer Care Inc

Greenbrae, California, United States, 94904

Actively Recruiting

5

Kaiser Permanente - Harbor City

Harbor City, California, United States, 90710

Actively Recruiting

6

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States, 90033

Actively Recruiting

7

USC Norris Cancer Center

Newport Beach, California, United States, 92663

Actively Recruiting

8

Sutter Medical Group, Roseville Clinic

Roseville, California, United States, 95661

Withdrawn

9

Sutter Health Medical Center

Sacramento, California, United States, 95816

Withdrawn

10

The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente

Torrance, California, United States, 90502

Actively Recruiting

11

Rocky Mountain Cancer Centers

Littleton, Colorado, United States, 80120-4413

Actively Recruiting

12

Georgetown University Medical Center

Washington D.C., District of Columbia, United States, 20007

Actively Recruiting

13

MedStar Washington Hosp Center

Washington D.C., District of Columbia, United States, 20010

Actively Recruiting

14

AdventHealth Altamonte

Altamonte Springs, Florida, United States, 32701

Actively Recruiting

15

Florida Cancer Specialists - Broadway

Fort Myers, Florida, United States, 33901

Actively Recruiting

16

Cancer Specialists of North Florida

Jacksonville, Florida, United States, 32256

Actively Recruiting

17

Florida Cancer Specialists - North;725 6th Ave South (St. Petersburg)

St. Petersburg, Florida, United States, 33701-4553

Actively Recruiting

18

Comprehensive Hematology Oncology

St. Petersburg, Florida, United States, 33709

Actively Recruiting

19

Florida Cancer Specialists - EAST - SCRI - PPDS

West Palm Beach, Florida, United States, 33401-3406

Actively Recruiting

20

Grady Health System

Atlanta, Georgia, United States, 30303

Actively Recruiting

21

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States, 30329

Actively Recruiting

22

Advocate Lutheran General Hospital

Park Ridge, Illinois, United States, 60068

Actively Recruiting

23

Springfield Clinic

Springfield, Illinois, United States, 62702

Actively Recruiting

24

Mission Cancer + Blood - IMMC

Des Moines, Iowa, United States, 50309

Actively Recruiting

25

Baptist Health Lexington

Lexington, Kentucky, United States, 40503

Actively Recruiting

26

Baptist Health Hamburg

Lexington, Kentucky, United States, 40509

Actively Recruiting

27

Baptist Health Louisville

Louisville, Kentucky, United States, 40207

Actively Recruiting

28

New England Cancer Specialists

Scarborough, Maine, United States, 04074

Actively Recruiting

29

Maryland Oncology Hematology

Annapolis, Maryland, United States, 21401

Actively Recruiting

30

Frederick Health Hospital

Frederick, Maryland, United States, 21702

Withdrawn

31

Dana Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

32

Henry Ford Hospital

Detroit, Michigan, United States, 48202

Actively Recruiting

33

HCA Midwest Division

Kansas City, Missouri, United States, 64132

Actively Recruiting

34

Cancer Care Center of O'Fallon

O'Fallon, Missouri, United States, 62269

Actively Recruiting

35

Oncology Hematology West - Grand Island

Grand Island, Nebraska, United States, 68803

Actively Recruiting

36

Oncology Hematology West - Legacy

Omaha, Nebraska, United States, 68130-2042

Actively Recruiting

37

Astera Cancer Care East Brunswick

East Brunswick, New Jersey, United States, 08816

Actively Recruiting

38

Capital Health Regional Medical Center

Pennington, New Jersey, United States, 08534

Withdrawn

39

Queens Hospital Cancer Center

Jamaica, New York, United States, 11432

Actively Recruiting

40

Duke Women Cancer Care

Raleigh, North Carolina, United States, 27607

Actively Recruiting

41

Oncology Hematology Care

Cincinnati, Ohio, United States, 45242

Withdrawn

42

Asante Rogue Regional Medical Center

Medford, Oregon, United States, 97504-8332

Actively Recruiting

43

Alliance Cancer Specialists

Bensalem, Pennsylvania, United States, 19020

Actively Recruiting

44

Ann B. Barshinger Cancer Institute

Lancaster, Pennsylvania, United States, 17604

Actively Recruiting

45

Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit

Philadelphia, Pennsylvania, United States, 19106

Actively Recruiting

46

WellSpan Oncology Research

York, Pennsylvania, United States, 17403

Withdrawn

47

Brown University Health

Providence, Rhode Island, United States, 02905

Actively Recruiting

48

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Actively Recruiting

49

Avera Cancer Institute - Aberdeen

Aberdeen, South Dakota, United States, 57401

Actively Recruiting

50

Avera Cancer Institute

Sioux Falls, South Dakota, United States, 57105

Actively Recruiting

51

West Cancer Center

Germantown, Tennessee, United States, 38138

Actively Recruiting

52

SCRI Oncology Partners

Nashville, Tennessee, United States, 37203

Actively Recruiting

53

Texas Oncology Cancer Center

Austin, Texas, United States, 78731

Actively Recruiting

54

JPS Oncology & Infusion Center

Fort Worth, Texas, United States, 76104

Actively Recruiting

55

Texas Oncology - DFW

Irving, Texas, United States, 75063

Actively Recruiting

56

Virginia Cancer Specialists, PC

Fairfax, Virginia, United States, 22031

Actively Recruiting

57

Virginia Commonwealth University - Massey Cancer Center

Richmond, Virginia, United States, 23219

Actively Recruiting

58

Northwest Medical Specialties

Tacoma, Washington, United States, 98405

Actively Recruiting

59

West Virginia University Hospitals Inc

Morgantown, West Virginia, United States, 26056

Actively Recruiting

60

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States, 54311

Actively Recruiting

61

Aurora St Lukes Medical Center

Milwaukee, Wisconsin, United States, 53215

Actively Recruiting

62

Centro de Investigaciones Médicas y Desarrollo LC S.R.L

Buenos Aires, Argentina, C1113AAE

Actively Recruiting

63

Inst. de Oncologia Angel H. Roffo

Buenos Aires, Argentina, C1417DTB

Actively Recruiting

64

Centro Oncologico Korben

Ciudad Autonoma Buenos Aires, Argentina, C1426AGE

Actively Recruiting

65

Sanatorio Allende

Córdoba, Argentina, X5000JHQ

Actively Recruiting

66

Centro Oncologico Riojano Integral (CORI)

La Rioja, Argentina, F5300COE

Actively Recruiting

67

Hospital Alemán

Recoleta, Argentina, C1118AAT

Actively Recruiting

68

Instituto de Oncología de Rosario

Rosario, Argentina, S2000KZE

Actively Recruiting

69

Sanatorio Parque S.A.

Rosario, Argentina, S2000QGB

Actively Recruiting

70

Hospital Provincial del Centenario

Rosario, Argentina, S2002KDS

Actively Recruiting

71

Centro Oncológico de Excelencia

San Juan, Argentina, J5400

Actively Recruiting

72

Northern Beaches Hospital

Frenchs Forest, New South Wales, Australia, 2086

Actively Recruiting

73

Nepean Hospital

Kingswood, New South Wales, Australia, 2747

Actively Recruiting

74

Mater Hospital

North Sydney, New South Wales, Australia, 2060

Actively Recruiting

75

University of the Sunshine Coast

Sippy Downs, Queensland, Australia, 4556

Actively Recruiting

76

Mater Misericordiae Limited

South Brisbane, Queensland, Australia, 4101

Actively Recruiting

77

Cancer Research SA

Adelaide, South Australia, Australia

Actively Recruiting

78

Barwon Health

Geelong, Victoria, Australia, 3220

Actively Recruiting

79

Sunshine Hospital

St Albans, Victoria, Australia, 3021

Actively Recruiting

80

South West Healthcare

Warrnambool, Victoria, Australia, 3280

Withdrawn

81

Lkh-Univ. Klinikum Graz

Graz, Austria, 8036

Actively Recruiting

82

Medical University Innsbruck

Innsbruck, Austria, 6020

Withdrawn

83

Ordensklinikum Linz Barmherzige Schwestern

Linz, Austria, 4010

Actively Recruiting

84

Oö. Gesundheits- und Spitals-AG/LKH Steyr

Steyr, Austria, 4400

Actively Recruiting

85

Medizinische Universität Wien

Vienna, Austria, 1090

Withdrawn

86

Cliniques Universitaires St-Luc

Brussels, Belgium, 1200

Actively Recruiting

87

GHdC Site Les Viviers

Charleroi, Belgium, 6060

Actively Recruiting

88

UZ Gent

Ghent, Belgium, 9000

Actively Recruiting

89

UZ Leuven Gasthuisberg

Leuven, Belgium, 3000

Actively Recruiting

90

CHU de Liège (Sart Tilman)

Liège, Belgium, 4000

Actively Recruiting

91

AZ St Maarten Campus Leopoldstr

Mechelen, Belgium, 2800

Actively Recruiting

92

Clinique Ste-Elisabeth

Namur, Belgium, 5000

Actively Recruiting

93

ZAS Sint Augustinus Wilrijk

Wilrijk, Belgium, 2610

Actively Recruiting

94

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará, Brazil, 60336-232

Actively Recruiting

95

CEDOES - Diagnóstico e Pesquisa

Vitória, Espírito Santo, Brazil, 29055-450

Actively Recruiting

96

Obras Sociais Irma Dulce - Osid

Salvador, Estado de Bahia, Brazil, 40415-006

Actively Recruiting

97

Hospital Sírio-Libanês

Brasília, Federal District, Brazil, 70200-730

Actively Recruiting

98

Hospital Araujo Jorge

Goiânia, Goiás, Brazil, 74605-070

Actively Recruiting

99

Hospital Sao Domingos

São Luís, Maranhão, Brazil, 65060-645

Actively Recruiting

100

Hospital do Câncer de Londrina

Londrina, Paraná, Brazil, 86015-520

Actively Recruiting

101

Hospital do Cancer de Pernambuco - HCP

Recife, Pernambuco, Brazil, 50040-000

Actively Recruiting

102

Vencer Oncoclínica - Centro de Pesquisa do Piauí

Teresina, Piauí, Brazil, 64049-200

Actively Recruiting

103

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, Rio Grande do Sul, Brazil, 98700-000

Actively Recruiting

104

Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil, 90020-090

Actively Recruiting

105

Hospital Moinhos de Vento

Porto Alegre, Rio Grande do Sul, Brazil, 90035-000

Actively Recruiting

106

Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul, Brazil, 90610-000

Actively Recruiting

107

Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, Brazil, 91350-200

Actively Recruiting

108

Hospital de Cancer de Barretos

Barretos, São Paulo, Brazil, 14784-400

Actively Recruiting

109

Hospital Amaral Carvalho

Jaú, São Paulo, Brazil, 17210-120

Actively Recruiting

110

Hospital Sírio-Libanês

São Paulo, São Paulo, Brazil, 01308-050

Actively Recruiting

111

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

São Paulo, São Paulo, Brazil, 01317-001

Actively Recruiting

112

Hospital A. C. Camargo

São Paulo, São Paulo, Brazil, 01509-010

Actively Recruiting

113

Instituto D'Or de Pesquisa e Ensino

Rio de Janeiro, Brazil, 22281-100

Actively Recruiting

114

Cross Cancer Institute

Edmonton, Alberta, Canada, T6G 1Z2

Actively Recruiting

115

Royal Victoria Regional Health Centre

Barrie, Ontario, Canada, L4M 6M2

Actively Recruiting

116

Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre

Mississauga, Ontario, Canada, L5M 2N1

Actively Recruiting

117

Lakeridge Health Oshawa

Oshawa, Ontario, Canada, L1G 2B9

Actively Recruiting

118

Thunder Bay Regional Health Sciences Centre

Thunder Bay, Ontario, Canada, P7B 6V4

Actively Recruiting

119

North York General Hospital

Toronto, Ontario, Canada, M2K 1E1

Actively Recruiting

120

Princess Margaret Cancer Center

Toronto, Ontario, Canada, M5G 2M9

Actively Recruiting

121

CIUSSS du Saguenay Lac-Saint-Jean, Chicoutimi Hospital

Chicoutimi, Quebec, Canada, G7H 5H6

Actively Recruiting

122

CISSS Chaudière-Appalaches

Lévis, Quebec, Canada, G6V 3Z1

Actively Recruiting

123

Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, Canada, H2X 0C2

Actively Recruiting

124

McGill University Health Centre - Glen Site

Montreal, Quebec, Canada, H4A 3J1

Withdrawn

125

CHU de Québec - Hôpital du Saint-Sacrement

Québec, Quebec, Canada, G1S 4L8

Actively Recruiting

126

Hopital regional de saint jerome

Saint-Jérôme, Quebec, Canada, J7Z 5T3

Actively Recruiting

127

Centre hospitalier regional de Trois-Rivieres

Trois-Rivières, Quebec, Canada, G8Z 3R9

Actively Recruiting

128

Allan Blair Cancer Centre

Regina, Saskatchewan, Canada, S4T 7T1

Actively Recruiting

129

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, Canada, SK S7N 4H4

Actively Recruiting

130

Hospital las Higueras

Concepción, Región Bio Bio, Chile, Alto Horno 777

Actively Recruiting

131

Medicina de Precisión - Celerity

Las Condes, Chile, 7560908

Actively Recruiting

132

Clínica Puerto Montt

Port Montt, Chile, 5500243

Actively Recruiting

133

Oncovida

Providencia, Chile, 750000

Actively Recruiting

134

Centro De Cancer Universidad Catolica

Santiago, Chile, 8330032

Actively Recruiting

135

Instituto Nacional del Cancer

Santiago, Chile, 8380000

Actively Recruiting

136

Icegclinic

Santiago, Chile

Actively Recruiting

137

Beijing Cancer Hospital

Beijing, China, 100142

Actively Recruiting

138

the First Hospital of Jilin University

Changchun, China, 130021

Actively Recruiting

139

Hunan Cancer Hospital

Changsha, China, 410013

Actively Recruiting

140

West China Hospital of Sichuan University

Chengdu, China, 610041

Actively Recruiting

141

Sichuan Provincial People's Hospital

Chengdu, China, 610072

Actively Recruiting

142

The First Affiliated Hospital, Chongqing Medical University

Chongqing, China, 400016

Withdrawn

143

Fujian Medical University Union Hospital

Fuzhou, China, 350001

Actively Recruiting

144

No. 900 Hospital (Fuzhou General Hospital)

Fuzhou, China, 350009

Actively Recruiting

145

Cancer Center, Sun Yat-sen University of Medical Sciences

Guangzhou, China, 510060

Actively Recruiting

146

The Second Affiliated Hospital of Zhejiang University College

Hangzhou, China, 310009

Actively Recruiting

147

Harbin Medical University Cancer Hospital

Harbin, China, 150081

Actively Recruiting

148

Jinan Central Hospital

Jinan, China, 250013

Actively Recruiting

149

Shandong Cancer Hospital

Jinan, China, 250117

Actively Recruiting

150

The First People's Hospital of Yunnan Province

Kunming, China, 650034

Actively Recruiting

151

The First Affiliated Hospital to Henan University of Science and Technology

Luoyang, China, 471003

Actively Recruiting

152

Guangxi Cancer Hospital of Guangxi Medical University

Nanning, China, 530021

Actively Recruiting

153

Zhongshan Hospital Fudan University

Shanghai, China, 200032

Actively Recruiting

154

Fudan University Shanghai Cancer Center

Shanghai, China, 200120

Actively Recruiting

155

Shanxi Province Cancer Hospital

Taiyuan, China, 030013

Actively Recruiting

156

Taizhou Hospital of Zhejiang Province

Taizhou, China

Withdrawn

157

Tianjin Cancer Hospital

Tianjin, China

Actively Recruiting

158

The Tumor Hospital of Xinjiang Medical University

Ürümqi, China, 830000

Actively Recruiting

159

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China, 430022

Actively Recruiting

160

Hubei Cancer Hospital

Wuhan, China, 430079

Actively Recruiting

161

The Second Affiliated Hospital of Xi'an Jiao Tong University

Xi'an, China, 710004

Actively Recruiting

162

Xi'an International Medical Center Hospital

Xi'an, China, 710100

Actively Recruiting

163

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, China

Actively Recruiting

164

Zhejiang Cancer Hospital

Zhejiang, China, 310022

Actively Recruiting

165

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, China, 450052

Actively Recruiting

166

Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo

Bogota, D.C., Colombia, 110131

Actively Recruiting

167

Clinica Colsanitas S.A. sede Clinica Universitaria Colombia

Bogotá D.C., Colombia, 51000

Actively Recruiting

168

IPS Salud SURA Chipichape Cali

Cali, Colombia

Actively Recruiting

169

Oncomedica S.A.

Montería, Colombia, 230002

Actively Recruiting

170

Sociedad de Oncología y hematología del Cesar Ltda

Valledupar, Colombia, 200001

Actively Recruiting

171

Clinica CIMCA

San José, Costa Rica, 10103

Actively Recruiting

172

ICIMED Instituto de Investigación en Ciencias Médicas

San José, Costa Rica, 10108

Actively Recruiting

173

Proclinical Pharma

San José, Costa Rica, 11303

Withdrawn

174

Kuopio Uni Hospital

Kuopio, Finland, 70211

Actively Recruiting

175

Tampere University Hospital

Tampere, Finland, 33520

Actively Recruiting

176

ICO Paul Papin

Angers, France, 49055

Actively Recruiting

177

Institut Sainte Catherine

Avignon, France, 84918

Actively Recruiting

178

Hopital Jean Minjoz

Besançon, France, 25030

Actively Recruiting

179

Centre Francois Baclesse

Caen, France, 14076

Actively Recruiting

180

Centre Jean Perrin

Clermont-Ferrand, France, 63011

Actively Recruiting

181

Centre Hospitalier Saint Louis

La Rochelle, France, 17019

Actively Recruiting

182

Centre Oscar Lambret

Lille, France, 59020

Actively Recruiting

183

Centre Leon Berard

Lyon, France, 69373

Actively Recruiting

184

Centre Cancerologie Grand Montpellier

Montpellier, France, 34070

Actively Recruiting

185

Institut Jean Godinot

Reims, France, 51056

Actively Recruiting

186

Centre Eugene Marquis

Rennes, France, 35042

Actively Recruiting

187

IUCT Oncopole

Toulouse, France, 31100

Actively Recruiting

188

Gustave Roussy

Villejuif, France, 94805

Actively Recruiting

189

Sozialstiftung Bamberg, Klinikum am Bruderwald, Gynäkologie

Bamberg, Germany, 96049

Actively Recruiting

190

St. Elisabeth Krankenhaus Köln GmbH

Cologne, Germany, 50935

Actively Recruiting

191

DONAU ISAR Klinikum Deggendorf

Deggendorf, Germany, 94469

Withdrawn

192

Gynonco Düsseldorf, MVZ Medical Center GmbH

Düsseldorf, Germany, 40235

Completed

193

Universitätsklinikum Erlangen

Erlangen, Germany, 91054

Actively Recruiting

194

Kliniken Essen-Mitte

Essen, Germany, 45136

Actively Recruiting

195

Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

Freiburg im Breisgau, Germany, 79110

Actively Recruiting

196

Nationales Centrum für Tumorerkrankungen (NCT)

Heidelberg, Germany, 69120

Actively Recruiting

197

Universitätsklinikum des Saarlandes

Homburg/Saar, Germany, 66424

Actively Recruiting

198

Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

Mönchengladbach, Germany, 41061

Actively Recruiting

199

Rotkreuzklinikum München

München, Germany, 80637

Actively Recruiting

200

Anticancer Hospital Ag. Savas

Athens, Greece, 115 22

Actively Recruiting

201

Aretaieio Hospital of Athens

Athens, Greece, 115 28

Actively Recruiting

202

University Hospital of Larissa

Larissa, Greece, 411 10

Actively Recruiting

203

University Hospital of Patras Medical Oncology

Pátrai, Greece, 265 04

Actively Recruiting

204

European Interbalkan Medical Center

Thessaloniki, Greece, 570 01

Actively Recruiting

205

Oncomedica

Guatemala City, Guatemala, 01009

Actively Recruiting

206

Celan S.A.

Guatemala City, Guatemala, 01010

Actively Recruiting

207

INTEGRA Cancer Institute

Guatemala City, Guatemala, 01010

Actively Recruiting

208

Onco Go, S.A.

Guatemala City, Guatemala, 01010

Actively Recruiting

209

Grupo Angeles

Guatemala City, Guatemala, 01015

Actively Recruiting

210

Medi-k

Guatemala City, Guatemala, 01016

Actively Recruiting

211

Centro Medico Integral de Cancerologia CEMIC

Salcajá, Guatemala, 09002

Actively Recruiting

212

Pamela Youde Nethersole Eastern Hospital

Hong Kong, Hong Kong

Actively Recruiting

213

Queen Mary Hospital

Hong Kong, Hong Kong

Actively Recruiting

214

Orszagos Onkologiai Intezet

Budapest, Hungary, 1122

Actively Recruiting

215

Bács-Kiskun Vármegyei Oktatókórház

Kecskemét, Hungary, 6000

Actively Recruiting

216

B-A-Z Vármegyei Központi Kórház és Egyetemi Oktatókórház

Miskolc, Hungary, 3526

Actively Recruiting

217

Nograd Varmegyei Szent Lazar Korhaz

Salgótarján, Hungary, 3100

Actively Recruiting

218

HealthCare Global Enterprises Limited

Banglore, Karnataka, India, 560027

Actively Recruiting

219

MVR Cancer Centre and Research Institute

Kozhikode, Kerala, India, 673601

Actively Recruiting

220

Regional Cancer Centre

Trivandrum, Kerala, India, 695011

Actively Recruiting

221

Sir H. N. Reliance Foundation Hospital and Research Centre

Mumbai, Maharashtra, India, 400004

Actively Recruiting

222

Grant Medical Foundation, Ruby Hall Clinic

Pune, Maharashtra, India, 411001

Actively Recruiting

223

Sahyadri Speciality Hospital

Pune, Maharashtra, India, 411004

Actively Recruiting

224

Sunact Cancer Institute

Thane, Maharashtra, India, 400615

Actively Recruiting

225

Max Super Speciality Hospital

New Delhi, National Capital Territory of Delhi, India, 110017

Withdrawn

226

Hadassah Ein Karem Hospital

Jerusalem, Israel, 9112000

Actively Recruiting

227

Rabin Medical Center

Petah Tikva, Israel, 4910000

Actively Recruiting

228

Sheba MC

Ramat Gan, Israel, 5265601

Actively Recruiting

229

Sourasky Medical Center

Tel Aviv, Israel, 6423900

Actively Recruiting

230

Presidio Ospedaliero di Summa-Perrino

Brindisi, Apulia, Italy, 72100

Actively Recruiting

231

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati

Avellino, Campania, Italy, 83100

Actively Recruiting

232

Azienda Ospedaliera Universitaria Federico II

Naples, Campania, Italy, 80131

Actively Recruiting

233

Istituto Nazionale Tumori Irccs Fondazione g. PASCALE

Naples, Campania, Italy, 80131

Actively Recruiting

234

Policlinico S.Orsola-Malpighi

Bologna, Emilia-Romagna, Italy, 40138

Actively Recruiting

235

I.R.S.T Srl IRCCS

Meldola, Emilia-Romagna, Italy, 47014

Actively Recruiting

236

A.O. Universitaria Di Parma

Parma, Emilia-Romagna, Italy, 43100

Actively Recruiting

237

RCCS - Centro di Riferimento

Aviano (PN), Friuli Venezia Giulia, Italy, 33081

Actively Recruiting

238

A.O. Universitaria S. Maria Della Misericordia Di Udine

Udine, Friuli Venezia Giulia, Italy, 33100

Actively Recruiting

239

Policlinico Universitario Agostino Gemelli

Rome, Lazio, Italy, 00168

Actively Recruiting

240

Università Campus Bio-Medico di Roma

Rome, Lazio, Italy, 128

Actively Recruiting

241

Asst Papa Giovanni XXIII

Bergamo, Lombardy, Italy, 24127

Actively Recruiting

242

Asst Degli Spedali Civili Di Brescia

Brescia, Lombardy, Italy, 25123

Actively Recruiting

243

Asst Di Cremona

Cremona, Lombardy, Italy, 26100

Actively Recruiting

244

Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Lombardy, Italy, 20133

Actively Recruiting

245

Istituto Clinico Humanitas

Rozzano, Lombardy, Italy, 20089

Actively Recruiting

246

A.O.U. Maggiore della Carità

Novara, Piedmont, Italy, 28100

Actively Recruiting

247

Humanitas Centro Catanese Di Oncologia

Misterbianco (CT), Sicily, Italy, 95045

Actively Recruiting

248

Ospedale Di Macerata

Province of Macerata, The Marches, Italy, 62100

Actively Recruiting

249

Azienda Ospedaliera Universitaria Careggi

Florence, Tuscany, Italy, 50134

Actively Recruiting

250

IOV - Istituto Oncologico Veneto - IRCCS

Padova, Veneto, Italy, 35128

Actively Recruiting

251

University of Nairobi - Institute of Tropical and Infectious Diseases

Nairobi, Kenya

Actively Recruiting

252

Panamerican Clinical Research S.A de C.V.

Guadalajara, Jalisco, Mexico, 44670

Actively Recruiting

253

RENATI INNOVATION S.A.P.I. de C.V

Guadalajara, Jalisco, Mexico, 44680

Actively Recruiting

254

Productos y Servicios Oncologicos Acacias SA de CV

Mexico City, Mexico CITY (federal District), Mexico, 03240

Actively Recruiting

255

Centro de Atencion Oncologica Viva S de RL de CV

Mexico City, Mexico CITY (federal District), Mexico, 06760

Actively Recruiting

256

Hospital Zambrano Hellion TecSalud

Monterrey, Nuevo León, Mexico

Actively Recruiting

257

Centro de Investigacion Clinica de Oaxaca

Oaxaca City, Oaxaca, Mexico, 68020

Actively Recruiting

258

PanAmerican Clinical Research, Querétaro

Queréaro, Querétaro, Mexico, 76230

Actively Recruiting

259

CENEIT Oncologicos

Mexico City, Mexico, 03100

Actively Recruiting

260

Clinica Alivia sucursal Coyoacan

Mexico City, Mexico, 04010

Actively Recruiting

261

Christchurch Hospital

Christchurch, New Zealand

Actively Recruiting

262

Palmerston North Hospital

Palmerston North, New Zealand, 4442

Actively Recruiting

263

Whangarei Hospital

Whangarei, New Zealand, 0110

Actively Recruiting

264

Centro Medico Monte Carmelo

Arequipa, Peru, 04001

Actively Recruiting

265

Hospital Goyeneche

Arequipa, Peru, 5154

Actively Recruiting

266

Clínica Santa Beatriz

Lima, Peru, 15072

Completed

267

Hospital Nacional Arzobispo Loayza

Lima, Peru, 1

Actively Recruiting

268

Oncosalud Sac

Lima, Peru, 41

Actively Recruiting

269

Instituto Nacional de Enfermedades Neoplasicas

Lima, Peru, Lima 34

Actively Recruiting

270

Clinica Internacional, Sede San Borja

Lima, Peru, Lima 41

Actively Recruiting

271

Instituto Peruano de Oncología y Radioterapia

Lima, Peru

Actively Recruiting

272

Clinica San Antonio;Investigaciones Trujillo S.A.C.

Trujillo, Peru, 13008

Actively Recruiting

273

Clinica Peruana Americana

Trujillo, Peru, 13011

Withdrawn

274

Instituto Regional de Enfermedades Neoplasicas - IREN Norte

Trujillo, Peru, 13014

Actively Recruiting

275

Instytut "Centrum Zdrowia Matki Polki"

?ód?, Poland, 93-338

Actively Recruiting

276

Centrum Onkologii im. Prof. Franciszka ?ukaszczyka

Bydgoszcz, Poland, 85-796

Actively Recruiting

277

Szpital Morski Im. Pck

Gdynia, Poland, 81-519

Actively Recruiting

278

Narodowy Instytut Onkologii Odzia? w Gliwicach

Gliwice, Poland, 44-102

Actively Recruiting

279

?wi?tokrzyskie Centrum Onkologii

Kielce, Poland, 25-734

Actively Recruiting

280

Przychodnia Lekarska KOMED, Roman Karaszewski

Konin, Poland, 62-500

Actively Recruiting

281

Szpital Wojewódzki im. Miko?aja Kopernika

Koszalin, Poland, 75-581

Actively Recruiting

282

Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli

Lublin, Poland, 20-090

Actively Recruiting

283

Opolskie Centrum Onkologii

Opole, Poland, 45-061

Withdrawn

284

Mazowiecki Szpital Wojewódzki im. ?w. Jana Paw?a II

Siedlce, Poland, 08-110

Actively Recruiting

285

Zachodniopomorskie Centrum Onkologii

Szczecin, Poland, 71-730

Actively Recruiting

286

Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad

Warsaw, Poland, 02-781

Actively Recruiting

287

IPO de Coimbra

Coimbra, Portugal, 3000-075

Actively Recruiting

288

Hospital de S. Francisco Xavier

Lisbon, Portugal, 1495-005

Actively Recruiting

289

Hospital da Luz

Lisbon, Portugal, 1500-650

Actively Recruiting

290

IPO do Porto

Porto, Portugal, 4200-072

Actively Recruiting

291

CHVNG/E_Unidade 1

Vila Nova de Gaia, Portugal, 4434-502

Actively Recruiting

292

PanOncology Trials

San Juan, Puerto Rico, 00935

Actively Recruiting

293

Spitalul Clinic Filantropia

Bucharest, Romania, 011171

Actively Recruiting

294

Institutul Oncologic Prof. Dr. Alexandru Trestioreanu

Bucharest, Romania, 022328

Actively Recruiting

295

Amethyst Cluj

Cluj County, Romania, 407280

Actively Recruiting

296

Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca

Cluj-Napoca, Romania, 400015

Actively Recruiting

297

Centrul de Oncologie Sfantul Nectarie

Craiova, Romania, 200347

Actively Recruiting

298

Institutul Regional de Oncologie Iasi

Iași, Romania, 700483

Actively Recruiting

299

Centrul de Oncologie Oncohelp

Timișoara, Romania, 300239

Actively Recruiting

300

National University Hospital

Singapore, Singapore, 119228

Actively Recruiting

301

National Cancer Centre

Singapore, Singapore, 168583

Actively Recruiting

302

Icon Cancer Centre Gleneagles

Singapore, Singapore, 258499

Actively Recruiting

303

Institute of Oncology Ljubljana

Ljubljana, Slovenia, 1000

Actively Recruiting

304

Cancercare Rondebosch Oncology

Cape Town, South Africa, 7700

Withdrawn

305

Cancercare

Port Elizabeth, South Africa, 6045

Actively Recruiting

306

Steve Biko Academic Hospital

Pretoria, South Africa, 0002

Actively Recruiting

307

Kyungpook National University Chilgok Hospital

Daegu, South Korea, 41404

Actively Recruiting

308

Seoul National University Bundang Hospital

Seongnam-si, South Korea, 13620

Actively Recruiting

309

Korea University Anam Hospital

Seoul, South Korea, 02841

Actively Recruiting

310

Seoul National University Hospital

Seoul, South Korea, 03080

Actively Recruiting

311

Severance Hospital, Yonsei University Health System

Seoul, South Korea, 03722

Actively Recruiting

312

Asan Medical Center

Seoul, South Korea, 05505

Actively Recruiting

313

Gangnam Severance Hospital

Seoul, South Korea, 06273

Actively Recruiting

314

Ewha Womans University Mokdong Hospital

Seoul, South Korea, 07985

Actively Recruiting

315

Samsung Medical Center

Seoul, South Korea, 135-710

Actively Recruiting

316

Ulsan University Hosiptal

Ulsan, South Korea, 44033

Actively Recruiting

317

Institut Catala d?Oncologia Hospital Germans Trias i Pujol

Badalona, Barcelona, Spain, 08916

Actively Recruiting

318

Hospital de Jerez de la Frontera

Jerez de la Frontera, Cadiz, Spain, 11407

Actively Recruiting

319

Hospital Quiron de Madrid

Pozuelo de Alarcón, Madrid, Spain, 28223

Actively Recruiting

320

Hospital Universitario Virgen de La Arrixaca

EL Palmar (EL Palmar), Murcia, Spain, 30120

Actively Recruiting

321

Hospital Alvaro Cunqueiro

Vigo, Pontevedra, Spain, 36213

Actively Recruiting

322

Hospital Universitari Dexeus - Grupo Quironsalud

Barcelona, Spain, 08028

Actively Recruiting

323

Hospital Universitari Vall d'Hebron

Barcelona, Spain, 08035

Actively Recruiting

324

Hospital Juan Ramon Jimenez

Huelva, Spain, 21005

Actively Recruiting

325

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico

Jaén, Spain, 23007

Actively Recruiting

326

Centro Oncologico MD Anderson Internacional

Madrid, Spain, 28033

Actively Recruiting

327

Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal

Madrid, Spain, 28050

Actively Recruiting

328

Hospital Universitario Virgen Macarena

Seville, Spain, 41009

Actively Recruiting

329

Hospital Universitario Virgen del Rocio

Seville, Spain, 41013

Actively Recruiting

330

Instituto Valenciano Oncologia

Valencia, Spain, 46009

Actively Recruiting

331

Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia

Valencia, Spain, 46015

Actively Recruiting

332

Hsin-Chu Branch of National Taiwan University Hospital

Hsinchu, Taiwan, 300

Actively Recruiting

333

China Medical University Hospital

Taichung, Taiwan, 404

Actively Recruiting

334

Veterans General Hospital

Taipei, Taiwan, 00112

Actively Recruiting

335

National Taiwan Uni Hospital

Taipei, Taiwan, 100

Actively Recruiting

336

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, Taiwan, 11259

Actively Recruiting

337

Veterans General Hospital - Taichung

Xitun Dist., Taiwan, 40705

Actively Recruiting

338

Chulalongkorn Hospital

Bangkok, Thailand, 10330

Actively Recruiting

339

National Cancer Institute

Bangkok, Thailand, 10400

Actively Recruiting

340

Rajavithi Hospital

Bangkok, Thailand, 10400

Actively Recruiting

341

Chulabhorn Hospital

Lak Si, Thailand, 10210

Actively Recruiting

342

Maharaj Nakorn Chiang Mai Hospital;Depart of Radiology

Muang Chiang MAI Delivery Branch 3, Thailand, 50200

Actively Recruiting

343

Songklanagarind Hospital

Songkhla, Thailand, 90110

Actively Recruiting

344

Sakarya Training and Research Hospital

Adapazarı, Turkey (Türkiye), 54290

Actively Recruiting

345

Ankara City Hospital

Ankara, Turkey (Türkiye), 06800

Actively Recruiting

346

Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji

Bakirkoy / Istanbul, Turkey (Türkiye), 34147

Actively Recruiting

347

Izmir Ataturk Training and Research Hospital

Izmir, Turkey (Türkiye), 35360

Actively Recruiting

348

Goztepe Prof.Dr. Suleyman Yalcin City Hospital

Kadiköy, Turkey (Türkiye), 34722

Actively Recruiting

349

Mersin City Education and Research Hospital

Mersin, Turkey (Türkiye), 33240

Actively Recruiting

350

Medikal Park Samsun

Samsun, Turkey (Türkiye), 55200

Actively Recruiting

351

Hacettepe Uni Medical Faculty Hospital

Sihhiye/Ankara, Turkey (Türkiye), 06230

Actively Recruiting

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Research Team

R

Reference Study ID Number: CO44657 https://forpatients.roche.com/

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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