Actively Recruiting
A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
Led by Janssen Research & Development, LLC · Updated on 2026-04-13
240
Participants Needed
40
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening
- Have active PsA defined by at least 3 swollen joints and at least 3 tender joints at screening and baseline
- Have C-reactive protein (CRP) of 0.1 mg/dL or higher at screening from the central laboratory
- Have at least one of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis without rheumatoid nodules, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis
- Have active plaque psoriasis with at least one psoriatic plaque of 2 centimeters or more in diameter or nail changes consistent with psoriasis
- Female participants of childbearing potential must have negative serum pregnancy test at screening and negative urine pregnancy test at Week 0 prior to intervention
You will not qualify if you...
- Have a nonplaque form of psoriasis such as erythrodermic, guttate, or pustular psoriasis
- Have a history or current signs of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (except PsA), psychiatric, genitourinary, or metabolic disorders
- Have known or suspected allergies, hypersensitivity, or intolerance to JNJ-88545223 or excipients including placebo, or history of severe allergic reaction, angioedema, or anaphylaxis to drugs or food
- Have fibromyalgia or osteoarthritis symptoms that could interfere with efficacy assessments
- Currently have a malignancy or a history of malignancy within 5 years before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
Unity Health-White County Medical Center
Searcy, Arkansas, United States, 72143
Actively Recruiting
2
Newport Huntington Medical Group
Huntington Beach, California, United States, 92648
Actively Recruiting
3
Rheumatology Center of San Diego
San Diego, California, United States, 92128
Actively Recruiting
4
American Research, LLC
Cutler Bay, Florida, United States, 33157
Actively Recruiting
5
Innovation Medical Research Center
Palmetto Bay, Florida, United States, 33157
Actively Recruiting
6
Clinical Research of West Florida
Tampa, Florida, United States, 33606
Actively Recruiting
7
Conquest Research
Winter Park, Florida, United States, 32789
Actively Recruiting
8
Atlanta Research Center for Rheumatology
Marietta, Georgia, United States, 30060
Actively Recruiting
9
Willow Rheumatology and Wellness PLLC
Willowbrook, Illinois, United States, 60527
Actively Recruiting
10
Qualmedica Research
Evansville, Indiana, United States, 47715
Actively Recruiting
11
Joint and Muscle Research Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
12
Paramount Medical Research & Consulting
Middleburg Heights, Ohio, United States, 44130
Actively Recruiting
13
Clinical Research Philadelphia
Philadelphia, Pennsylvania, United States, 19114
Actively Recruiting
14
Arthritis and Rheumatology Research Institute
Allen, Texas, United States, 75013
Actively Recruiting
15
Peking University People's Hospital
Beijing, China, 100044
Actively Recruiting
16
Peking University Third Hospital
Beijing, China, 100191
Actively Recruiting
17
Changzhou No 2 Peoples Hospital
Changzhou, China, 213003
Actively Recruiting
18
West China Hospital Sichuan University
Chengdu, China, 610093
Actively Recruiting
19
The Second Affiliated Hospital of Zhejiang University
Hangzhou, China, 310009
Actively Recruiting
20
Ningbo medical center lihuili hospital
Ningbo, China, 315041
Actively Recruiting
21
Hamburger Rheuma Forschungszentrum II
Hamburg, Germany, 20095
Actively Recruiting
22
CAIR Heidelberg
Heidelberg, Germany, 69121
Actively Recruiting
23
Hautarztpraxis Mortazawi
Remscheid, Germany, 42897
Actively Recruiting
24
Hautarztpraxis
Witten, Germany, 58453
Actively Recruiting
25
Imamura General Hospital
Kagoshima, Japan, 890-0064
Actively Recruiting
26
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Japan, 807-8556
Actively Recruiting
27
Osaka Metropolitan University Hospital
Osaka, Japan, 545 8586
Actively Recruiting
28
Sanuki Municipal Hospital
Sanuki, Japan, 769-2393
Actively Recruiting
29
Tokito Clinic Rheumatology and Orthopaedic Surgery
Shimonoseki, Japan, 752 0976
Actively Recruiting
30
Nzoz Osteo Medic
Bialystok, Poland, 15 351
Actively Recruiting
31
Centrum Kliniczno Badawcze
Elblag, Poland, 82-300
Actively Recruiting
32
Malopolskie Badania Kliniczne Sp z o o
Krakow, Poland, 30-002
Actively Recruiting
33
Pratia MCM Krakow
Krakow, Poland, 30-727
Actively Recruiting
34
Etyka Osrodek Badan Klinicznych Tomasz Pesta S K A
Olsztyn, Poland, 10 117
Actively Recruiting
35
MICS Centrum Medyczne Warszawa 1
Warsaw, Poland, 00-872
Actively Recruiting
36
Centrum Medyczne Reuma Park
Warsaw, Poland, 02 665
Actively Recruiting
37
FutureMeds Targowek
Warsaw, Poland, 03 291
Actively Recruiting
38
Hosp Univ A Coruna
A Coruña, Spain, 15006
Actively Recruiting
39
Hosp. Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
40
Hosp. Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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