Actively Recruiting
Phase 3 Study to Test KarXT Medicine for Treating Schizophrenia in Teens Aged 13 to 17
Led by Bristol-Myers Squibb · Updated on 2026-07-20
166
Participants Needed
39
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the efficacy and safety of KarXT for treating schizophrenia in adolescents aged 13 to 17 years. This phase 3, randomized, double-blind, placebo-controlled study aims to better understand how KarXT impacts symptoms of schizophrenia, a serious mental health condition characterized by psychosis and other challenges. The study is sponsored by Bristol-Myers Squibb and focuses on adolescents experiencing active symptoms and meeting diagnostic criteria. Participants are randomly assigned to receive either KarXT or a matching placebo at specified doses on scheduled days. The study uses a parallel design with two groups one receiving the experimental drug KarXT and the other receiving placebo. Treatment and observation last through the study period, with key assessments taking place up to week 5. Participants will undergo evaluations including symptom severity scales such as the Positive and Negative Syndrome Scale PANSS, Clinical Global Impression scales, and the Childrens Global Assessment Scale CGAS. Researchers monitor changes from baseline in these measures to understand the impact of KarXT. Safety and symptom assessments occur throughout the trial, which runs until December 2029, allowing for careful monitoring of participant health and treatment effects.
CONDITIONS
Brief Title
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
Research Team
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