Actively Recruiting
A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization
Led by AstraZeneca · Updated on 2026-05-07
435
Participants Needed
183
Research Sites
135 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
AZD0292 is a bispecific IgG1k mAb being evaluated for the prevention of exacerbations in bronchiectasis patients chronically colonized with PsA.
CONDITIONS
Official Title
A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be 63 12 years of age at the time of signing the informed consent/assent
- Weight 63 35 kg
- Bronchiectasis diagnosed by a physician and confirmed by CT demonstrating abnormal bronchial dilation in 63 1 lobe; historical CT within 5 years acceptable or CT at screening
- Receiving standard of care therapy with documented history of 63 2 moderate or 63 1 severe exacerbations requiring antibiotics in past 12 months
- Clinically stable and free from bronchiectasis exacerbation for 4 weeks before randomization
- Pre- or post-bronchodilator FEV1 63 25% predicted value at screening
- Positive (PCR or culture) PsA in airway sample at least once in last 24 months prior to screening
- Culture positive PsA in sputum within 5 weeks of randomization; prior PsA eradication therapy allowed if colonized
- Capable of giving signed informed consent/assent and complying with protocol requirements
You will not qualify if you...
- Primary lung diagnosis other than bronchiectasis
- Active tuberculosis or nontuberculous mycobacteria treated or needing treatment; treatment completed allowed
- Active allergic bronchopulmonary aspergillosis treated or needing treatment
- Need for long term supplemental oxygen; oxygen use for ambulation or exercise relief allowed
- Current or recent malignancy within 5 years except stable prostate cancer, treated skin or cervical cancers
- AIDS or advanced HIV disease with CD4 count < 200 cells/mm3
- History of severe allergic reaction to monoclonal antibodies or immune complex disease
- New long term anti-PsA antibiotics, macrolides, or DPP-1 inhibitors started within 3 months prior to screening
- New chronic immunosuppressive therapy (prednisolone > 5 mg or equivalent) initiated within last 3 months
- Receipt of investigational products for bronchiectasis exacerbations treatment or prevention
- CF patients on CFTR modulator therapies started within previous 3 months
- Female participants who are pregnant, lactating, or women of childbearing potential not using effective contraception or abstinence from 4 weeks before to 6 months after intervention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 183 locations
1
Research Site
Orange, California, United States, 92868
Not Yet Recruiting
2
Research Site
San Francisco, California, United States, 94143
Actively Recruiting
3
Research Site
Denver, Colorado, United States, 80206
Not Yet Recruiting
4
Research Site
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
5
Research Site
Jacksonville, Florida, United States, 32209
Actively Recruiting
6
Research Site
Miami Lakes, Florida, United States, 33014
Suspended
7
Research Site
Naples, Florida, United States, 34102
Actively Recruiting
8
Research Site
Ormond Beach, Florida, United States, 32174
Actively Recruiting
9
Research Site
Plantation, Florida, United States, 33324
Actively Recruiting
10
Research Site
Rincon, Georgia, United States, 31326
Actively Recruiting
11
Research Site
Kansas City, Kansas, United States, 66160
Actively Recruiting
12
Research Site
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
13
Research Site
Rochester, Minnesota, United States, 55905
Withdrawn
14
Research Site
St Louis, Missouri, United States, 63130
Actively Recruiting
15
Research Site
New York, New York, United States, 10016
Actively Recruiting
16
Research Site
New Bern, North Carolina, United States, 28562
Not Yet Recruiting
17
Research Site
Winston-Salem, North Carolina, United States, 27104
Not Yet Recruiting
18
Research Site
Tulsa, Oklahoma, United States, 74133
Withdrawn
19
Research Site
DuBois, Pennsylvania, United States, 15801
Withdrawn
20
Research Site
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
21
Research Site
Charleston, South Carolina, United States, 29425
Not Yet Recruiting
22
Research Site
Rock Hill, South Carolina, United States, 29732
Actively Recruiting
23
Research Site
Austin, Texas, United States, 78705
Withdrawn
24
Research Site
Mansfield, Texas, United States, 76063
Actively Recruiting
25
Research Site
Ciudad de Buenos Aires, Argentina, C1180AAX
Actively Recruiting
26
Research Site
Florida, Argentina, B1602DQD
Actively Recruiting
27
Research Site
Rosario, Argentina, 2000
Actively Recruiting
28
Research Site
San Miguel de Tucumán, Argentina, 4000
Actively Recruiting
29
Research Site
Birtinya, Australia, 4575
Not Yet Recruiting
30
Research Site
Macquarie University, Australia, 2109
Not Yet Recruiting
31
Research Site
South Brisbane, Australia, 4101
Actively Recruiting
32
Research Site
Ghent, Belgium, 9000
Actively Recruiting
33
Research Site
Leuven, Belgium, 3000
Actively Recruiting
34
Research Site
Liège, Belgium, 4000
Actively Recruiting
35
Research Site
Sint-Niklaas, Belgium, 9100
Actively Recruiting
36
Research Site
Blumenau, Brazil, 89030-101
Actively Recruiting
37
Research Site
Campinas, Brazil, 13060-080
Actively Recruiting
38
Research Site
Curitiba, Brazil, 80030-110
Actively Recruiting
39
Research Site
Curitiba, Brazil, 80230-130
Not Yet Recruiting
40
Research Site
Porto Alegre, Brazil, 9061-000
Actively Recruiting
41
Research Site
Porto Alegre, Brazil, 90630-165
Not Yet Recruiting
42
Research Site
Porto Alegre, Brazil, 91350-200
Not Yet Recruiting
43
Research Site
Salvador, Brazil, 40050-410
Withdrawn
44
Research Site
São José dos Campos, Brazil, 12230-001
Not Yet Recruiting
45
Research Site
São Paulo, Brazil, 05.403-010
Not Yet Recruiting
46
Research Site
São Paulo, Brazil, 05403-000
Actively Recruiting
47
Research Site
Calgary, Alberta, Canada, T2N4Z6
Actively Recruiting
48
Research Site
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
49
Research Site
Ajax, Ontario, Canada, L1S 2J5
Actively Recruiting
50
Research Site
Stoney Creek, Ontario, Canada, L8G 2V6
Actively Recruiting
51
Research Site
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
52
Research Site
Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
Actively Recruiting
53
Research Site
Trois-Rivières, Quebec, Canada, G8T 7A1
Withdrawn
54
Research Site
Concepción, Chile, 4070196
Not Yet Recruiting
55
Research Site
Santiago, Chile, 8150000
Not Yet Recruiting
56
Research Site
Santiago, Chile, 8380453
Not Yet Recruiting
57
Research Site
Talca, Chile, 3481349
Not Yet Recruiting
58
Research Site
Viña del Mar, Chile, 2540364
Not Yet Recruiting
59
Research Site
Aalborg, Denmark, 9000
Actively Recruiting
60
Research Site
Aarhus N, Denmark, 8200
Withdrawn
61
Research Site
Hvidovre, Denmark, 2650
Actively Recruiting
62
Research Site
Odense C, Denmark, 5000
Actively Recruiting
63
Research Site
Roskilde, Denmark, 4000
Actively Recruiting
64
Research Site
Brest, France, 29200
Actively Recruiting
65
Research Site
Créteil, France, 94010
Actively Recruiting
66
Research Site
Marseille, France, 13915
Not Yet Recruiting
67
Research Site
Montpellier, France, 34295
Actively Recruiting
68
Research Site
Paris, France, 75014
Actively Recruiting
69
Research Site
Pessac, France, 33604
Actively Recruiting
70
Research Site
Strasbourg, France, 67091
Actively Recruiting
71
Research Site
Toulouse, France, 31100
Actively Recruiting
72
Research Site
Darmstadt, Germany, 64283
Withdrawn
73
Research Site
Essen, Germany, 45239
Actively Recruiting
74
Research Site
Frankfurt, Germany, 60596
Actively Recruiting
75
Research Site
Halle, Germany, 06108
Actively Recruiting
76
Research Site
Hanover, Germany, 30625
Actively Recruiting
77
Research Site
Konstanz, Germany, 78464
Actively Recruiting
78
Research Site
München, Germany, 80336
Not Yet Recruiting
79
Research Site
München-Pasing, Germany, 81241
Actively Recruiting
80
Research Site
Athens, Greece, 11527
Actively Recruiting
81
Research Site
Athens, Greece, 12462
Actively Recruiting
82
Research Site
Athens, Greece, 15126
Actively Recruiting
83
Research Site
Athens, Greece, 17562
Actively Recruiting
84
Research Site
Ioannina, Greece, 45500
Actively Recruiting
85
Research Site
Larissa, Greece, 41110
Actively Recruiting
86
Research Site
Pátrai, Greece, 26500
Actively Recruiting
87
Research Site
Thessaloniki, Greece, 57010
Actively Recruiting
88
Research Site
Ashkelon, Israel, 7830604
Actively Recruiting
89
Research Site
Haifa, Israel, 34362
Actively Recruiting
90
Research Site
Jerusalem, Israel, 00000
Actively Recruiting
91
Research Site
Jerusalem, Israel, 91031
Actively Recruiting
92
Research Site
Ramat Gan, Israel, 52621
Actively Recruiting
93
Research Site
Tel Aviv, Israel, 6423906
Actively Recruiting
94
Research Site
Milan, Italy, 20122
Actively Recruiting
95
Research Site
Palermo, Italy, 90127
Actively Recruiting
96
Research Site
Pavia, Italy, 27100
Actively Recruiting
97
Research Site
Perugia, Italy, 06129
Actively Recruiting
98
Research Site
Roma, Italy, 00163
Actively Recruiting
99
Research Site
Rozzano, Italy, 20089
Actively Recruiting
100
Research Site
Torrette, Italy, 60126
Actively Recruiting
101
Research Site
Bunkyō City, Japan, 113-8655
Not Yet Recruiting
102
Research Site
Gifu, Japan, 500-8717
Not Yet Recruiting
103
Research Site
Hiratsuka-shi, Japan, 254-8502
Not Yet Recruiting
104
Research Site
Kamogawa-shi, Japan, 296-0041
Not Yet Recruiting
105
Research Site
Kiyose-shi, Japan, 204-8522
Not Yet Recruiting
106
Research Site
Kiyose-shi, Japan, 204-8585
Not Yet Recruiting
107
Research Site
Kurashiki-shi, Japan, 710-8602
Not Yet Recruiting
108
Research Site
Miyazaki, Japan, 889-1692
Not Yet Recruiting
109
Research Site
Nagasaki, Japan, 852-8501
Not Yet Recruiting
110
Research Site
Ogi, Japan, 845-0032
Not Yet Recruiting
111
Research Site
Shinjuku-ku, Japan, 160-8582
Not Yet Recruiting
112
Research Site
Shinjuku-ku, Japan, 162-8655
Not Yet Recruiting
113
Research Site
Urayasu-shi, Japan, 279-0021
Not Yet Recruiting
114
Research Site
Bandar Puncak Alam, Malaysia, 42300
Not Yet Recruiting
115
Research Site
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
116
Research Site
Sibu, Malaysia, 96000
Actively Recruiting
117
Research Site
Amsterdam, Netherlands, 1081 HV
Not Yet Recruiting
118
Research Site
Rotterdam, Netherlands, 3015 GD
Not Yet Recruiting
119
Research Site
Zutphens, Netherlands, 7207 AE
Withdrawn
120
Research Site
Bellavista, Peru, CALLAO 2
Withdrawn
121
Research Site
Callao, Peru, Bellavista
Not Yet Recruiting
122
Research Site
Lima, Peru, 15023
Not Yet Recruiting
123
Research Site
Lima, Peru, 15036
Actively Recruiting
124
Research Site
Lima, Peru, 15038
Actively Recruiting
125
Research Site
Lima, Peru, 15082
Not Yet Recruiting
126
Research Site
Lima, Peru, 15088
Withdrawn
127
Research Site
Lima, Peru, LIMA 1
Actively Recruiting
128
Research Site
Lima, Peru, LIMA 29
Withdrawn
129
Research Site
Iloilo City, Philippines, 5000
Not Yet Recruiting
130
Research Site
Manila, Philippines, 1000
Not Yet Recruiting
131
Research Site
Quezon City, Philippines, 1100
Not Yet Recruiting
132
Research Site
Tondo, Philippines, 1012
Not Yet Recruiting
133
Research Site
Anyang-si, South Korea, 14068
Actively Recruiting
134
Research Site
Cheongju-si, South Korea, 28644
Actively Recruiting
135
Research Site
Daegu, South Korea, 42415
Actively Recruiting
136
Research Site
Seongnam-si, South Korea, 13620
Actively Recruiting
137
Research Site
Seoul, South Korea, 04763
Actively Recruiting
138
Research Site
Seoul, South Korea, 05030
Actively Recruiting
139
Research Site
Seoul, South Korea, 05505
Actively Recruiting
140
Research Site
Seoul, South Korea, 07441
Actively Recruiting
141
Research Site
Ulsan, South Korea, 44033
Actively Recruiting
142
Research Site
Barcelona, Spain, 08003
Actively Recruiting
143
Research Site
Barcelona, Spain, 08036
Actively Recruiting
144
Research Site
Benalmádena, Spain, 29631
Actively Recruiting
145
Research Site
Madrid, Spain, 28040
Actively Recruiting
146
Research Site
Madrid, Spain, 28046
Actively Recruiting
147
Research Site
Mérida, Spain, 06800
Not Yet Recruiting
148
Research Site
Patraix, Spain, 46017
Actively Recruiting
149
Research Site
Valencia, Spain, 46009
Actively Recruiting
150
Research Site
Kaohsiung City, Taiwan, 80756
Actively Recruiting
151
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
152
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
153
Research Site
Taipei, Taiwan, 0116
Actively Recruiting
154
Research Site
Taipei, Taiwan, 10002
Actively Recruiting
155
Research Site
Taipei, Taiwan, 110
Not Yet Recruiting
156
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
157
Research Site
Bang Kra So, Thailand, 11000
Actively Recruiting
158
Research Site
Bangkok, Thailand, 10400
Actively Recruiting
159
Research Site
Khon Kaen, Thailand, 40002
Actively Recruiting
160
Research Site
Muang, Thailand, 50200
Actively Recruiting
161
Research Site
Pathum Thani, Thailand, 12120
Actively Recruiting
162
Research Site
Adana, Turkey (Türkiye), 1330
Actively Recruiting
163
Research Site
Ankara, Turkey (Türkiye), 6340
Actively Recruiting
164
Research Site
Diyarbakır, Turkey (Türkiye), 21280
Actively Recruiting
165
Research Site
Istanbul, Turkey (Türkiye), 34098
Actively Recruiting
166
Research Site
Istanbul, Turkey (Türkiye), 34890
Actively Recruiting
167
Research Site
Mersin, Turkey (Türkiye), 33343
Actively Recruiting
168
Research Site
Zeytinburnu, Turkey (Türkiye), 34020
Actively Recruiting
169
Research Site
Belfast, United Kingdom, BT9 7AB
Actively Recruiting
170
Research Site
Birmingham, United Kingdom, B9 5SS
Actively Recruiting
171
Research Site
Brighton, United Kingdom, BN2 1ES
Actively Recruiting
172
Research Site
Cambridge, United Kingdom, CB2 0AY
Actively Recruiting
173
Research Site
Dundee, United Kingdom, DD1 9SY
Actively Recruiting
174
Research Site
Edinburgh, United Kingdom, EH16 4SA
Actively Recruiting
175
Research Site
Exeter, United Kingdom, EX2 5DW
Actively Recruiting
176
Research Site
Liverpool, United Kingdom, L14 3PE
Actively Recruiting
177
Research Site
Manchester, United Kingdom, M23 9LT
Actively Recruiting
178
Research Site
Can Tho, Vietnam, 900000
Not Yet Recruiting
179
Research Site
Haiphong, Vietnam, 180000
Not Yet Recruiting
180
Research Site
Hanoi, Vietnam, 100000
Not Yet Recruiting
181
Research Site
Hà Nội, Vietnam, 100000
Not Yet Recruiting
182
Research Site
Ho Chi Minh City, Vietnam, 700000
Not Yet Recruiting
183
Research Site
Huế, Vietnam, 530000
Not Yet Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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