Actively Recruiting
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Led by Novartis Pharmaceuticals · Updated on 2026-05-12
1275
Participants Needed
180
Research Sites
424 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to provide efficacy and safety data for remibrutinib in patients with secondary progressive multiple sclerosis (SPMS)
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent prior to any assessments
- Male or female aged 18 to 65 years at screening
- Diagnosis of secondary progressive multiple sclerosis per 2017 revised McDonald criteria
- No clinical relapses in the 24 months before screening and randomization
- Expanded Disability Status Scale (EDSS) score between 3.0 and 6.0 at screening
- Documented disability progression in the 12 months before screening
You will not qualify if you...
- Unable or unwilling to undergo MRI scans (e.g., due to claustrophobia or contraindications like metallic implants or pacemaker)
- History of significant central nervous system diseases such as stroke, traumatic brain or spinal injury, or neurological disorders mimicking multiple sclerosis
- Ongoing substance abuse or psychiatric conditions interfering with study compliance
- History of confirmed progressive multifocal leukoencephalopathy (PML) or symptoms consistent with PML
- Women of childbearing potential not using highly effective contraception during and for at least 1 week after treatment
- Significant bleeding risk or coagulation disorders at screening
- Use of exclusionary medications before screening or randomization as per protocol
- Other protocol-defined exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 180 locations
1
Alabama Neurology Associates PC
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
AZ Integrated Neuro and Spine
Phoenix, Arizona, United States, 85037
Actively Recruiting
3
Center for Neurosciences
Tucson, Arizona, United States, 85718
Actively Recruiting
4
Fullerton Neuro and Headache Ctr
Fullerton, California, United States, 92835
Actively Recruiting
5
Regina Berkovich MD PhD Inc
West Hollywood, California, United States, 90048
Actively Recruiting
6
Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
7
Medstar Washington Hosp Ctr
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
8
Neurology of Central FL Res Ctr
Altamonte Springs, Florida, United States, 32714
Actively Recruiting
9
UF Health Cancer Center
Gainesville, Florida, United States, 32610
Actively Recruiting
10
Homestead Assoc In Research Inc
Homestead, Florida, United States, 33033
Actively Recruiting
11
Neurology Associates PA
Maitland, Florida, United States, 32751
Actively Recruiting
12
Miami NS Ins Baptist Health S FL
Miami, Florida, United States, 33176
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13
Aqualane Clinical Research
Naples, Florida, United States, 34105
Actively Recruiting
14
Orlando Health Clinical Trials
Orlando, Florida, United States, 32806
Actively Recruiting
15
Comprehensive Neurology Clinic
Orlando, Florida, United States, 32825
Actively Recruiting
16
Neurology Associates of Ormond Beach
Ormond Beach, Florida, United States, 32174
Actively Recruiting
17
Axiom Brain Health
Tampa, Florida, United States, 33609
Actively Recruiting
18
Joi Life Wellness Group LLC
Smyrna, Georgia, United States, 30080
Actively Recruiting
19
Hawaii Pacific Neuroscience LLC
Honolulu, Hawaii, United States, 96817
Actively Recruiting
20
University of Kansas Hospital
Kansas City, Kansas, United States, 66160
Actively Recruiting
21
Mid Atlantic Epilepsy and Sleep Ctr
Bethesda, Maryland, United States, 20817-1807
Actively Recruiting
22
Neuro Institute of New England P C
Foxborough, Massachusetts, United States, 02035
Actively Recruiting
23
Michigan Institute of Neurological
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
24
University of New Mexico Hospital
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
25
Premier Neurology
Greenville, South Carolina, United States, 29605
Actively Recruiting
26
Neurology Clinic PC
Cordova, Tennessee, United States, 38018
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27
Saturn Research Solution
Plano, Texas, United States, 75024
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28
Citta Clinical Research
Spokane, Washington, United States, 99202
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29
Novartis Investigative Site
Capital Federal, Buenos Aires, Argentina, 1424
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30
Novartis Investigative Site
Bombal, Mendoza Province, Argentina, M5500DXO
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31
Novartis Investigative Site
Buenos Aires, Argentina, C1012AAR
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32
Novartis Investigative Site
Caba, Argentina, C1055AAF
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33
Novartis Investigative Site
CABA, Argentina, C1181ACH
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34
Novartis Investigative Site
Caba, Argentina, C1182
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35
Novartis Investigative Site
Caba, Argentina, C1424BYD
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36
Novartis Investigative Site
Santiago del Estero, Argentina, 4200
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37
Novartis Investigative Site
Kogarah, New South Wales, Australia, 2217
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38
Novartis Investigative Site
New Lambton Heights, New South Wales, Australia, 2305
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39
Novartis Investigative Site
Westmead, New South Wales, Australia, 2145
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40
Novartis Investigative Site
Clayton, Victoria, Australia, 3168
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41
Novartis Investigative Site
Heidelberg, Victoria, Australia, 3084
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42
Novartis Investigative Site
Linz, Austria, 4020
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43
Novartis Investigative Site
Vienna, Austria, 1180
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44
Novartis Investigative Site
Pleven, Bulgaria, 5800
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45
Novartis Investigative Site
Sofia, Bulgaria, 1113
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46
Novartis Investigative Site
Sofia, Bulgaria, 1407
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47
Novartis Investigative Site
Sofia, Bulgaria, 1431
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48
Novartis Investigative Site
Sofia, Bulgaria, 1510
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49
Novartis Investigative Site
Sofia, Bulgaria, 1606
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50
Novartis Investigative Site
Vancouver, British Columbia, Canada, V6T 2A1
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51
Novartis Investigative Site
Ottawa, Ontario, Canada, K1H 8L6
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52
Novartis Investigative Site
Lévis, Quebec, Canada, G6W 0M5
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53
Novartis Investigative Site
Montreal, Quebec, Canada, H2W 1T8
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54
Novartis Investigative Site
Montreal, Quebec, Canada, H3A 2B4
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55
Novartis Investigative Site
Montreal, Quebec, Canada, H4A 3T2
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56
Novartis Investigative Site
Sherbrooke, Quebec, Canada, J1H 5N4
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57
Novartis Investigative Site
Guangzhou, Guangdong, China, 510030
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58
Novartis Investigative Site
Zhengzhou, Henan, China, 450003
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59
Novartis Investigative Site
Wuhan, Hubei, China, 430030
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60
Novartis Investigative Site
Hohhot, Inner Mongolia, China, 010017
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61
Novartis Investigative Site
Suzhou, Jiangsu, China, 215004
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62
Novartis Investigative Site
Changchun, Jilin, China, 130021
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63
Novartis Investigative Site
Yinchuan, Ningxia, China, 750004
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64
Novartis Investigative Site
Xianyang, Shaanxi, China, 712000
Actively Recruiting
65
Novartis Investigative Site
Taiyuan, Shanxi, China, 030001
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66
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310016
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67
Novartis Investigative Site
Wenzhou, Zhejiang, China, 325000
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68
Novartis Investigative Site
Beijing, China, 065001
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69
Novartis Investigative Site
Beijing, China, 100034
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70
Novartis Investigative Site
Chongqing, China, 400016
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71
Novartis Investigative Site
Shanghai, China, 200040
Actively Recruiting
72
Novartis Investigative Site
Tianjin, China, 300052
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73
Novartis Investigative Site
Barranquilla, Atlántico, Colombia, 080020
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74
Novartis Investigative Site
Bogotá, Colombia, 111321
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75
Novartis Investigative Site
Medellín, Colombia, 050001
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76
Novartis Investigative Site
Medellín, Colombia, 050034
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77
Novartis Investigative Site
Jihlava, Czechia, 586 01
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78
Novartis Investigative Site
Prague, Czechia, 140 59
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79
Novartis Investigative Site
Prague, Czechia, 150 06
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80
Novartis Investigative Site
Teplice, Czechia, 415 29
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81
Novartis Investigative Site
Esbjerg, Denmark, 6700
Actively Recruiting
82
Novartis Investigative Site
Limoges, Haute Vienne, France, 87000
Actively Recruiting
83
Novartis Investigative Site
Ajaccio, France, 20090
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84
Novartis Investigative Site
Amiens, France, 80054
Actively Recruiting
85
Novartis Investigative Site
Clermont-Ferrand, France, 63003
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86
Novartis Investigative Site
Gonesse, France, 95500
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87
Novartis Investigative Site
Grenoble, France, 38043
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88
Novartis Investigative Site
Lille, France, 59000
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89
Novartis Investigative Site
Lille, France, 59037
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90
Novartis Investigative Site
Montpellier, France, 34090
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91
Novartis Investigative Site
Nancy, France, 54035
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92
Novartis Investigative Site
Nice, France, 06000
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93
Novartis Investigative Site
Nîmes, France, 30029
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94
Novartis Investigative Site
Orsay, France, 91400
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95
Novartis Investigative Site
Paris, France, 75013
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96
Novartis Investigative Site
Paris, France, 75940
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97
Novartis Investigative Site
Poitiers, France, 86021
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98
Novartis Investigative Site
Rennes, France, 35033
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99
Novartis Investigative Site
Rouen, France, 76031
Actively Recruiting
100
Novartis Investigative Site
Strasbourg, France, 67000
Actively Recruiting
101
Novartis Investigative Site
Toulouse, France, 31059
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102
Novartis Investigative Site
Tours, France, 37044
Actively Recruiting
103
Novartis Investigative Site
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106
Actively Recruiting
104
Novartis Investigative Site
Mannheim, Baden-Wurttemberg, Germany, 68167
Actively Recruiting
105
Novartis Investigative Site
Munich, Bavaria, Germany, 81377
Actively Recruiting
106
Novartis Investigative Site
Unterhaching, Bavaria, Germany, 82008
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107
Novartis Investigative Site
Halle, Saxony-Anhalt, Germany, 06120
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108
Novartis Investigative Site
Erfurt, Germany, 99089
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109
Novartis Investigative Site
Giessen, Germany, 35392
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110
Novartis Investigative Site
Greifswald, Germany, 17475
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111
Novartis Investigative Site
Heidelberg, Germany, 69120
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112
Novartis Investigative Site
Itzehoe, Germany, 25524
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113
Novartis Investigative Site
Tübingen, Germany, 72076
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114
Novartis Investigative Site
Chaïdári, Greece, 124 62
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115
Novartis Investigative Site
Budapest, Hungary, 1044
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116
Novartis Investigative Site
Kistarcsa, Hungary, 2143
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117
Novartis Investigative Site
Gurugram, Haryana, India, 122011
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118
Novartis Investigative Site
Mangalore, Karnataka, India, 575003
Actively Recruiting
119
Novartis Investigative Site
Kochi, Kerala, India, 682025
Actively Recruiting
120
Novartis Investigative Site
New Delhi, National Capital Territory of Delhi, India, 110029
Actively Recruiting
121
Novartis Investigative Site
New Delhi, National Capital Territory of Delhi, India, 110060
Actively Recruiting
122
Novartis Investigative Site
Chandigarh, Punjab, India, 160012
Actively Recruiting
123
Novartis Investigative Site
Vellore, Tamil Nadu, India, 632 004
Actively Recruiting
124
Novartis Investigative Site
Hyderabad, Telangana, India, 500082
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125
Novartis Investigative Site
Haifa, Israel, 3436212
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126
Novartis Investigative Site
Jerusalem, Israel, 9112001
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127
Novartis Investigative Site
Ramat Gan, Israel, 5265601
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128
Novartis Investigative Site
Rehovot, Israel, 7661041
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129
Novartis Investigative Site
Tel Aviv, Israel, 6423906
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130
Novartis Investigative Site
Ẕerifin, Israel, 7030000
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131
Novartis Investigative Site
Bergamo, BG, Italy, 24127
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132
Novartis Investigative Site
Foggia, FG, Italy, 71122
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133
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
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134
Novartis Investigative Site
Pavia, PV, Italy, 27100
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135
Novartis Investigative Site
Roma, RM, Italy, 00133
Actively Recruiting
136
Novartis Investigative Site
Arnhem, Gelderland, Netherlands, 6815 AD
Actively Recruiting
137
Novartis Investigative Site
Leiden, Netherlands, 2334 CN
Actively Recruiting
138
Novartis Investigative Site
Bydgoszcz, Woj Kujawsko Pomorskie, Poland, 85-796
Actively Recruiting
139
Novartis Investigative Site
Chojnice, Poland, 89-600
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140
Novartis Investigative Site
Katowice, Poland, 40-081
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141
Novartis Investigative Site
Katowice, Poland, 40-686
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142
Novartis Investigative Site
Rzeszów, Poland, 35-323
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143
Novartis Investigative Site
Skorzewo, Poland, 60-185
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144
Novartis Investigative Site
Zabrze, Poland, 41-800
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145
Novartis Investigative Site
Żory, Poland, 44-240
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146
Novartis Investigative Site
Braga, Portugal, 4710243
Actively Recruiting
147
Novartis Investigative Site
Lisbon, Portugal, 1349-019
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148
Novartis Investigative Site
Porto, Portugal, 4200 319
Actively Recruiting
149
Novartis Investigative Site
Constanța, ROM, Romania, 900123
Actively Recruiting
150
Novartis Investigative Site
Bucharest, Romania, 040215
Actively Recruiting
151
Novartis Investigative Site
Campulung Muscel, Romania, 115100
Actively Recruiting
152
Novartis Investigative Site
Bratislava, Slovakia, 851 01
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153
Novartis Investigative Site
Komárno, Slovakia, 945 05
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154
Novartis Investigative Site
Nitra, Slovakia, 950 01
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155
Novartis Investigative Site
Trnava, Slovakia, 917 02
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156
Novartis Investigative Site
Cape Town, Western Cape, South Africa, 7405
Actively Recruiting
157
Novartis Investigative Site
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
Actively Recruiting
158
Novartis Investigative Site
Pozuelo de Alarcón, Madrid, Spain, 28223
Actively Recruiting
159
Novartis Investigative Site
Torrejón de Ardoz, Madrid, Spain, 28850
Actively Recruiting
160
Novartis Investigative Site
El Palmar, Murcia, Spain, 30120
Actively Recruiting
161
Novartis Investigative Site
Castilleja de la Cuesta, Sevilla, Spain, 41950
Actively Recruiting
162
Novartis Investigative Site
Valencia, Valencia, Spain, 46017
Actively Recruiting
163
Novartis Investigative Site
Barakaldo, Vizcaya, Spain, 48903
Actively Recruiting
164
Novartis Investigative Site
Alicante, Spain, 03010
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165
Novartis Investigative Site
Barcelona, Spain, 08035
Actively Recruiting
166
Novartis Investigative Site
Las Palmas GC, Spain, 35010
Actively Recruiting
167
Novartis Investigative Site
Lleida, Spain, 25198
Actively Recruiting
168
Novartis Investigative Site
Madrid, Spain, 28009
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169
Novartis Investigative Site
Madrid, Spain, 28034
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170
Novartis Investigative Site
Madrid, Spain, 28040
Actively Recruiting
171
Novartis Investigative Site
Málaga, Spain, 29010
Actively Recruiting
172
Novartis Investigative Site
Salamanca, Spain, 37007
Actively Recruiting
173
Novartis Investigative Site
Valencia, Spain, 46026
Actively Recruiting
174
Novartis Investigative Site
Bern, Switzerland, 3010
Actively Recruiting
175
Novartis Investigative Site
Lausanne, Switzerland, 1011
Actively Recruiting
176
Novartis Investigative Site
Brighton, East Sussex, United Kingdom, BN2 5BE
Actively Recruiting
177
Novartis Investigative Site
Coventry, United Kingdom, CV2 2DX
Actively Recruiting
178
Novartis Investigative Site
Glasgow, United Kingdom, G51 4TF
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179
Novartis Investigative Site
Leeds, United Kingdom, LS1 3EX
Actively Recruiting
180
Novartis Investigative Site
Nottingham, United Kingdom, NG7 2UH
Actively Recruiting
Research Team
N
Novartis Pharmaceuticals
CONTACT
N
Novartis Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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