Actively Recruiting
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)
Led by Incyte Corporation · Updated on 2026-04-16
550
Participants Needed
101
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in participants with hidradenitis suppurativa.
CONDITIONS
Official Title
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of hidradenitis suppurativa for at least 6 months prior to screening visit
- Mild to moderate hidradenitis suppurativa (Hurley I or II) at screening and baseline
- At least 4 affected areas with no draining tunnels at screening and baseline
- Involvement of at least 2 distinct anatomical areas
- Agreement to avoid topical and systemic antibiotics during the vehicle-controlled period
- Agreement to avoid topical antiseptics on HS lesions during the vehicle-controlled and extension periods
You will not qualify if you...
- Body surface area to be treated exceeds 20% at screening or baseline
- Presence of draining tunnels at screening or baseline
- History or current infections, cancer, lymphoproliferative disorders, or other medical conditions per investigator discretion
- Laboratory values outside protocol-defined limits
- Pregnant or lactating or planning pregnancy during study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 101 locations
1
Investigative Site US020
Phoenix, Arizona, United States, 85008
Actively Recruiting
2
Investigative Site US033
Scottsdale, Arizona, United States, 85259
Actively Recruiting
3
Investigative Site US054
Tempe, Arizona, United States, 85282
Actively Recruiting
4
Investigative Site US002
Fayetteville, Arkansas, United States, 72703
Actively Recruiting
5
Investigative Site US055
Brea, California, United States, 92821
Actively Recruiting
6
Investigative Site US004
Laguna Niguel, California, United States, 92677
Actively Recruiting
7
Investigative Site US007
Los Angeles, California, United States, 90033
Actively Recruiting
8
Investigative Site US013
San Diego, California, United States, 92103
Actively Recruiting
9
Investigative Site US060
San Diego, California, United States, 92120
Actively Recruiting
10
Investigative Site US038
San Diego, California, United States, 92121
Actively Recruiting
11
Investigative Site US059
Aurora, Colorado, United States, 80045
Actively Recruiting
12
Investigative Site US045
Boynton Beach, Florida, United States, 33437
Actively Recruiting
13
Investigative Site US028
Fort Myers, Florida, United States, 33912
Actively Recruiting
14
Investigative Site US016
Miami, Florida, United States, 33142
Actively Recruiting
15
Investigative Site US027
Sanford, Florida, United States, 32771
Actively Recruiting
16
Investigative Site US057
Sweetwater, Florida, United States, 33172
Actively Recruiting
17
Investigative Site US029
Tampa, Florida, United States, 33609
Actively Recruiting
18
Investigative Site US061
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
19
Investigative Site US053
Atlanta, Georgia, United States, 30331
Actively Recruiting
20
Investigative Site US019
Marietta, Georgia, United States, 30060
Actively Recruiting
21
Investigative Site US026
Chicago, Illinois, United States, 60657
Actively Recruiting
22
Investigative Site US049
Clarksville, Indiana, United States, 47129
Actively Recruiting
23
Investigative Site US052
West Lafayette, Indiana, United States, 47906
Actively Recruiting
24
Investigative Site US001
Bowling Green, Kentucky, United States, 42104
Actively Recruiting
25
Investigative Site US022
Louisville, Kentucky, United States, 40241
Actively Recruiting
26
Investigative Site US050
Baton Rouge, Louisiana, United States, 70809
Actively Recruiting
27
Investigative Site US046
Glenn Dale, Maryland, United States, 20769
Actively Recruiting
28
Investigative Site US003
Boston, Massachusetts, United States, 02115
Actively Recruiting
29
Investigative Site US030
Boston, Massachusetts, United States, 02215
Actively Recruiting
30
Investigative Site US010
Quincy, Massachusetts, United States, 02169
Actively Recruiting
31
Investigative Site US051
Novi, Michigan, United States, 48377
Not Yet Recruiting
32
Investigative Site US006
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
33
Investigative Site US021
New Brighton, Minnesota, United States, 55112
Actively Recruiting
34
Investigative Site US036
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
35
Investigative Site US034
New City, New York, United States, 10956
Actively Recruiting
36
Investigative Site US018
New York, New York, United States, 10003
Actively Recruiting
37
Investigative Site US017
New York, New York, United States, 10023
Actively Recruiting
38
Investigative Site US023
Rochester, New York, United States, 14623
Actively Recruiting
39
Investigative Site US014
Chapel Hill, North Carolina, United States, 27516
Actively Recruiting
40
Investigative Site US025
Fargo, North Dakota, United States, 58103
Actively Recruiting
41
Investigative Site US015
Bexley, Ohio, United States, 43209
Actively Recruiting
42
Investigative Site US044
Cincinnati, Ohio, United States, 45219
Actively Recruiting
43
Investigative Site US008
Columbus, Ohio, United States, 43230
Actively Recruiting
44
Investigative Site US031
Mason, Ohio, United States, 45040
Actively Recruiting
45
Investigative Site US048
Oklahoma City, Oklahoma, United States, 73118
Actively Recruiting
46
Investigative Site US043
Danville, Pennsylvania, United States, 17822
Not Yet Recruiting
47
Investigative Site US056
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
48
Investigative Site US024
Charleston, South Carolina, United States, 29425
Actively Recruiting
49
Investigative Site US041
Myrtle Beach, South Carolina, United States, 29788
Actively Recruiting
50
Investigative Site US047
Nashville, Tennessee, United States, 37215
Actively Recruiting
51
Investigative Site US062
Dallas, Texas, United States, 75390
Actively Recruiting
52
Investigative Site US035
El Paso, Texas, United States, 79902
Actively Recruiting
53
Investigative Site US032
Frisco, Texas, United States, 75033
Actively Recruiting
54
Investigative Site US012
Plano, Texas, United States, 75025
Actively Recruiting
55
Investigative Site US011
San Antonio, Texas, United States, 78213
Actively Recruiting
56
Investigative Site US040
Layton, Utah, United States, 84041
Completed
57
Investigative Site US037
Murray, Utah, United States, 84107
Actively Recruiting
58
Investigative Site US039
Ogden, Utah, United States, 84405
Completed
59
Investigative Site US058
Seattle, Washington, United States, 98195
Actively Recruiting
60
Investigative Site BG002
Sofia, Bulgaria, 01407
Actively Recruiting
61
Investigative Site BG003
Sofia, Bulgaria, 01463
Actively Recruiting
62
Investigative Site CA004
Calgary, Alberta, Canada, T2J 7E1
Actively Recruiting
63
Investigative Site CA003
Calgary, Alberta, Canada, T3E 0B2
Actively Recruiting
64
Investigative Site CA009
Ottawa, Ontario, Canada, K1K 4L2
Actively Recruiting
65
Investigative Site CA002
Peterborough, Ontario, Canada, K9J 5K2
Actively Recruiting
66
Investigative Site CA001
Richmond Hill, Ontario, Canada, L4B 1L1
Actively Recruiting
67
Investigative Site CA007
Toronto, Ontario, Canada, M3B 0A7
Actively Recruiting
68
Investigative Site CA005
Toronto, Ontario, Canada, M4E 1R7
Actively Recruiting
69
Investigative Site CA006
Waterloo, Ontario, Canada, N2J 1C4
Actively Recruiting
70
Investigative Site CA008
Sherbrooke, Quebec, Canada, J1G 1X9
Actively Recruiting
71
Investigative Site FR002
Bordeaux, France, 33000
Actively Recruiting
72
Investigative Site FR005
Brest, France, 29609
Actively Recruiting
73
Investigative Site FR004
Nantes, France, 44093
Actively Recruiting
74
Investigative Site FR003
Nice, France, 06200
Actively Recruiting
75
Investigative Site FR001
Paris, France, 75010
Actively Recruiting
76
Investigative Site DE006
Berlin, Germany, 10117
Actively Recruiting
77
Investigative Site DE005
Berlin, Germany, 13595
Actively Recruiting
78
Investigative Site DE002
Bochum, Germany, 44791
Actively Recruiting
79
Investigative Site DE004
Darmstadt, Germany, 64283
Actively Recruiting
80
Investigative Site DE001
Dresden, Germany, 01307
Actively Recruiting
81
Investigative Site DE003
Erlangen, Germany, 91054
Actively Recruiting
82
Investigative Site DE007
Hamburg, Germany, 20246
Actively Recruiting
83
Investigative Site DE008
Lübeck, Germany, 23538
Actively Recruiting
84
Investigative Site IT001
Catania, Italy, 95123
Actively Recruiting
85
Investigative Site IT005
Cona, Italy, 44124
Actively Recruiting
86
Investigative Site IT009
Florence, Italy, 50122
Not Yet Recruiting
87
Investigative Site IT003
Milan, Italy, 20122
Actively Recruiting
88
Investigative Site IT007
Naples, Italy, 80131
Actively Recruiting
89
Investigative Site IT006
Roma, Italy, 00137
Actively Recruiting
90
Investigative Site IT004
Roma, Italy, 00144
Actively Recruiting
91
Investigative Site IT002
Rozzano, Italy, 20089
Actively Recruiting
92
Investigative Site IT008
Torino, Italy, 10126
Not Yet Recruiting
93
Investigative Site PL002
Lodz, Poland, 90-436
Actively Recruiting
94
Investigative Site PL003
Torun, Poland, 87-100
Actively Recruiting
95
Investigative Site PL001
Warsaw, Poland, 02-962
Actively Recruiting
96
Investigative Site PL004
Wroclaw, Poland, 54-239
Actively Recruiting
97
Investigative Site ES004
Alicante, Spain, 03010
Actively Recruiting
98
Investigative Site ES005
Badalona, Spain, 08916
Actively Recruiting
99
Investigative Site ES003
Barcelona, Spain, 08003
Actively Recruiting
100
Investigative Site ES001
Madrid, Spain, 28009
Actively Recruiting
101
Investigative Site ES002
Madrid, Spain, 28040
Actively Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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