Actively Recruiting
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Led by Incyte Corporation · Updated on 2026-04-14
240
Participants Needed
83
Research Sites
185 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician-diagnosed asthma requiring treatment with medium- to high-dose ICS-LABA for at least 12 months prior to screening.
- Pre-bronchodilator FEV1 less than 80% predicted at Visit 2.
- Documented post-bronchodilator reversibility of FEV1 of at least 12% and 200 mL.
- At least 2 asthma exacerbations requiring systemic corticosteroids, hospitalization, or emergency visit within 12 months prior to screening, but not within 4 weeks before screening.
- Asthma Control Questionnaire (ACQ-6) score of 1.5 or higher at screening.
You will not qualify if you...
- Use of asthma controllers other than ICS-LABA for maintenance.
- Previous bronchial thermoplasty treatment.
- Current smokers, history of 10 or more pack-years smoking, or use of vaping/electronic cigarettes.
- Pregnant, breastfeeding, or planning pregnancy.
- Other significant pulmonary diseases besides asthma.
- Blood disorders including thrombocytopenia, coagulopathy, or platelet dysfunction.
- History of venous or arterial thrombosis, heart failure (NYHA Class III or IV), stroke, myocardial infarction, coronary stenting, or coronary artery bypass graft surgery.
- Other significant cardiovascular diseases such as angina, peripheral arterial disease, or uncontrolled arrhythmias.
- Organ transplant recipients requiring ongoing immunosuppression.
- Immunocompromised status including lymphoma, AIDS, or Wiskott-Aldrich syndrome.
- Current or past malignancies.
- Chronic or recurrent infections.
- Use of biologic drugs for asthma within 12 weeks or 5 half-lives prior to screening.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 83 locations
1
Allervie Clinical Research
Birmingham, Alabama, United States, 35209
Completed
2
Kern Allergy Medical Clinic, Inc
Bakersfield, California, United States, 93301
Actively Recruiting
3
Integrated Research of Inland, Inc
Upland, California, United States, 91786
Completed
4
Qway Research
Hialeah, Florida, United States, 33010
Actively Recruiting
5
Direct Helpers Research Center
Hialeah, Florida, United States, 33012
Actively Recruiting
6
Care Research Inc
Miami, Florida, United States, 33130
Actively Recruiting
7
Verus Clinical Research Corp
Miami, Florida, United States, 33135
Actively Recruiting
8
Dr. de Armas Research Center, Llc
Miami, Florida, United States, 33174
Completed
9
Care Research Center, Inc
Miami, Florida, United States, 33175
Completed
10
Anderson Allergy and Asthma
Orlando, Florida, United States, 32806
Completed
11
Heuer Md Research Inc
Orlando, Florida, United States, 32819
Completed
12
Advanced Clinical Research Atlanta
Atlanta, Georgia, United States, 30309
Completed
13
Covenant Pulmonary Critical Care
East Point, Georgia, United States, 30344
Completed
14
Northshore Medical Group
Glenview, Illinois, United States, 60026
Completed
15
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Completed
16
Aa Medical Research Center
Flint, Michigan, United States, 48504
Completed
17
Revive Research Institute
Southfield, Michigan, United States, 48075
Completed
18
Northwell Health Physician Partners
New Hyde Park, New York, United States, 11040
Completed
19
Pioneer Clinical Research Ny
New York, New York, United States, 10016
Completed
20
Montefiore Medical Center (Mmc)
The Bronx, New York, United States, 10461
Completed
21
Onsite Clinical Solutions, Llc Charlotte Central Office
Charlotte, North Carolina, United States, 28277
Completed
22
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Completed
23
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States, 29732
Completed
24
Howland Allergy and Asthma Pllc Dba Orion Clinical Research
Austin, Texas, United States, 78759
Actively Recruiting
25
Linq Research, Llc
Pearland, Texas, United States, 77584
Actively Recruiting
26
Quality Assurance Research Center
San Antonio, Texas, United States, 78212
Completed
27
Fundacion Respirar
Buenos Aires, Argentina, 01426
Actively Recruiting
28
Fundacion Cidea
Buenos Aires, Argentina, 1125 ABE
Actively Recruiting
29
Mautalen Salud E Investigacion
Buenos Aires, Argentina, C1128AAF
Actively Recruiting
30
Care: Centro de Alergia Y Enfermedades Respiratorias
CABA, Argentina, C1414AIF
Actively Recruiting
31
INAER
Capitalfederal, Argentina, C1425BEN
Actively Recruiting
32
Centro de Medicina Respiratoria
Concepción del Uruguay, Argentina, 03260
Actively Recruiting
33
Instituto de Medicina Respiratoria - Imer
Córdoba, Argentina, X5003DCE
Actively Recruiting
34
Fundacion Enfisema
Mar del Plata, Argentina, B7612ENA
Actively Recruiting
35
Centro Medico Dharma
Mendoza, Argentina, 05500
Actively Recruiting
36
Polo de Salud Vistalba
Mendoza, Argentina, 05509
Actively Recruiting
37
Fundacion Scherbovsky
Mendoza, Argentina, M5500AXR
Actively Recruiting
38
INSARES
Mendoza, Argentina, MENDOZA (5500)
Actively Recruiting
39
Centro Respiratorio Quilmes
Quilmes, Argentina, 01878
Actively Recruiting
40
Centro Respiratorio Infantil
Rosario, Argentina, 02000
Actively Recruiting
41
Instituto de Diagnostico Abc
Rosario, Argentina, 02000
Actively Recruiting
42
Instituto Especialidades de La Salud Rosario
Rosario, Argentina, 02000
Actively Recruiting
43
Instituto Medico de La Fundacion Estudios Clinicos
Rosario, Argentina, S2000 DEJ
Actively Recruiting
44
Centro Medico Respire
San Fernando, Argentina, 01644
Actively Recruiting
45
Ierim Instituto de Enfermedades Respiratorias E Investigacion Medica
San Juan Bautista, Argentina, 01888
Actively Recruiting
46
Ipr Instituto de Patologias Respiratorias
San Miguel de Tucumán, Argentina, 04000
Actively Recruiting
47
Cimer - Centro Integral de Medicina Respiratoria Srl
San Miguel de Tucumán, Argentina, T4000 CBC
Actively Recruiting
48
Iba Medica
Santa Fe, Argentina, S3000ASF
Actively Recruiting
49
Synergy Respiratory Care
Sherwood Park, Alberta, Canada, T8H 0N2
Actively Recruiting
50
Centre For Lung Health
Vancouver, British Columbia, Canada, V5Z 1M9
Completed
51
Dynamic Drug Advancement
Ajax, Ontario, Canada, L1S2J5
Actively Recruiting
52
Hamilton Allergy
Hamilton, Ontario, Canada, L8S 1G5
Withdrawn
53
Ottawa Allergy Research Corporation
Ottawa, Ontario, Canada, K1H 1E4
Completed
54
S. Fikry Medicine Professional Corporation
Waterloo, Ontario, Canada, N2J 1C4
Actively Recruiting
55
Dr. Syed Anees Medicine Professional Corporation
Windsor, Ontario, Canada, N8X 1T3
Actively Recruiting
56
Pneumologische Gemeinschaftspraxis Kroker-Schaeben-Schmidt
Bendorf, Germany, 56170
Actively Recruiting
57
Universitatsklinikum Bonn Aoer
Bonn, Germany, 53127
Actively Recruiting
58
Ikf Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases
Frankfurt am Main, Germany, 60596
Actively Recruiting
59
Hannover Medical School
Hanover, Germany, 30625
Actively Recruiting
60
Ikf Pneumologie Mainz
Mainz, Germany, 55128
Actively Recruiting
61
Nihonbashi Medical and Allergy Clinic
Chūōku, Japan, 103-0022
Completed
62
Fukuwa Clinic
Chūōku, Japan, 104-0031
Actively Recruiting
63
National Hospital Organization Fukuoka National Hospital
Fukuoka, Japan, 811-1394
Actively Recruiting
64
Kishiwada City Hospital
Kishiwada, Japan, 596-8501
Actively Recruiting
65
Kirigaoka Tsuda Hospital
Kitakyushu-shi, Japan, 802-0052
Actively Recruiting
66
Tohno Chuo Clinic
Mizunami-shi, Japan, 509-6134
Actively Recruiting
67
Kyosokai Amc Nishi-Umeda Clinic
Osaka, Japan, 530-0001
Completed
68
Lee Clinic
Osaka, Japan, 531-0073
Completed
69
Sakaide City Hospital
Sakaide-shi, Japan, 762-8550
Actively Recruiting
70
Idaimae Minami Yojo Int Clinic
Sapporo, Japan, 064-0804
Completed
71
Tokyo Shinagawa Hospital
Shinagawa-ku, Japan, 140-8522
Actively Recruiting
72
Takahashi Medical Clinic
Tokyo, Japan, 185-0014
Completed
73
Kouwa Clinic
Toshima-ku, Japan, 170-0003
Completed
74
Local Independent Administrative Institution Mie Prefectural General Medical Center
Yokkaichi-shi, Japan, 510-8561
Actively Recruiting
75
Kaiseikai Kita Shin Yokohama Internal Medicine Clinic
Yokohama, Japan, 223-0059
Completed
76
Allergy Clinic Homeo Medicus
Bialystok, Poland, 15-687
Actively Recruiting
77
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Actively Recruiting
78
Nzoz Atopia
Krakow, Poland, 31-142
Actively Recruiting
79
Szpital Specjalistyczny Cdt Medicus
Lubin, Poland, 59-300
Completed
80
Ostrowieckie Centrum Medyczne Spka Cywilna Anna Olech-Cudzik Krzysztof Cudzik
Ostrowiec Świętokrzyski, Poland, 27-400
Actively Recruiting
81
Pim Mswia
Warsaw, Poland, 02-507
Completed
82
Giromed Institute/ Clinica Tres Torrres
Barcelona, Spain, 08017
Actively Recruiting
83
Hospital Clinic Barcelona Main
Barcelona, Spain, 08036
Actively Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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