Actively Recruiting
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)
Led by Incyte Corporation · Updated on 2026-05-08
330
Participants Needed
120
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate effect of povorcitinib on itch and skin lesions in participants with prurigo nodularis.
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants 18 to 75 years of age.
- Clinical diagnosis of prurigo nodularis for at least 3 months prior to screening.
- Average itch severity score of 7 or higher during the 7 days before baseline.
- At least 20 itchy nodular lesions on two or more body regions (legs, arms, trunk) at screening and baseline.
- Documented history of treatment failure, intolerance, or contraindication to previous prurigo nodularis treatments.
- Willingness to avoid pregnancy or fathering children during the study.
You will not qualify if you...
- Chronic itch caused by conditions other than prurigo nodularis or neuropathic/psychogenic itch.
- Prurigo nodularis caused by medications.
- Active atopic dermatitis lesions within 3 months prior to screening.
- Pregnant or breastfeeding women.
- History of blood disorders, significant cardiovascular diseases, disseminated herpes infections, chronic infections, or malignancies.
- Infection with tuberculosis, hepatitis B, hepatitis C, or HIV.
- Previous failure to topical or systemic JAK or TYK2 inhibitors for prurigo nodularis or inflammatory diseases.
- Laboratory test results outside protocol-defined ranges.
- Other protocol-defined inclusion/exclusion criteria apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 120 locations
1
Cahaba Dermatology
Birmingham, Alabama, United States, 35244
Actively Recruiting
2
Banner - University Medicine Multispecialty Services Clinic
Tucson, Arizona, United States, 85718
Actively Recruiting
3
Premier Dermatology Clinical Trials Institute At Northwest Arkansas
Fayetteville, Arkansas, United States, 72703
Completed
4
Burke Pharmaceutical Research
Hot Springs, Arkansas, United States, 71913
Actively Recruiting
5
Dermatology Research Associates
Los Angeles, California, United States, 90045
Actively Recruiting
6
Northridge
Northridge, California, United States, 91325
Actively Recruiting
7
Rendon Center the Dermatology and Aesthetic Center
Boca Raton, Florida, United States, 33486
Actively Recruiting
8
Driven Research Llc
Coral Gables, Florida, United States, 33134
Actively Recruiting
9
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
Actively Recruiting
10
Research Institute of the Southeast, Llc
West Palm Beach, Florida, United States, 33401
Actively Recruiting
11
Illinois Dermatology Institute the Chicago Loop
Chicago, Illinois, United States, 60602
Actively Recruiting
12
Chicago Cosmetic Surgery and Dermatology
Chicago, Illinois, United States, 60654
Completed
13
Center For Medical Dermatology and Immunology Research
Chicago, Illinois, United States, 60657
Actively Recruiting
14
Northshore University Healthsystem
Skokie, Illinois, United States, 60077
Completed
15
Dermatology Specialists Research Indiana
Clarksville, Indiana, United States, 47129
Actively Recruiting
16
Oakland Hills Dermatology
Auburn Hills, Michigan, United States, 48326
Actively Recruiting
17
Hamzavi Dermatology
Fort Gratiot, Michigan, United States, 48059
Completed
18
Somerset Skin Centre
Troy, Michigan, United States, 48084
Completed
19
Medisearch Clinical Trials
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
20
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
21
The University of New Mexico Unm Health Sciences Center Hsc
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
22
Montefiore Medical Center
East Syracuse, New York, United States, 13057
Completed
23
Skin Center Dermatology Group
New York, New York, United States, 10956
Actively Recruiting
24
Stony Brook Dermatology Associates
Stony Brook, New York, United States, 11790
Actively Recruiting
25
Centricity Research Columbus
Columbus, Ohio, United States, 43213
Actively Recruiting
26
Wright State Physicians Health Center
Dayton, Ohio, United States, 45324
Actively Recruiting
27
International Clinical Research Tennessee Llc
Murfreesboro, Tennessee, United States, 37130
Completed
28
Dermatology Treatment and Research Center
Dallas, Texas, United States, 75230
Actively Recruiting
29
Sweetwater Dermatology
Sugar Land, Texas, United States, 77479
Completed
30
Center For Clinical Studies
Webster, Texas, United States, 77598
Actively Recruiting
31
Frontier Dermatology
Mill Creek, Washington, United States, 98012
Actively Recruiting
32
Conexa Investigacion Clinica S.A.
Buenos Aires, Argentina, 01012
Actively Recruiting
33
Cedic - Centro de Investigacion Clinica
Buenos Aires, Argentina, C1060ABN
Actively Recruiting
34
Instituto de Neumonologia Y Dermatologia
Buenos Aires, Argentina, C1425BEA
Not Yet Recruiting
35
Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias (Inaer)
Buenos Aires, Argentina, C1425BEN
Actively Recruiting
36
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, Argentina, B7600FYK
Actively Recruiting
37
Instituto Especialidades de La Salud Rosario - Clinica Del Torax
Rosario, Argentina, S2000
Actively Recruiting
38
Investigaciones Reumatologicas Tucuman S.R.L.
San Miguel de Tucumán, Argentina, T4000AXL
Actively Recruiting
39
Medical University Graz University Clinic For Dermatology and Venerology
Graz, Austria, 08036
Actively Recruiting
40
Wiener Krankenanstaltenverbund, Krankenhaus Hietzing Mit Neurologischem Zentrum Rosenhugel
Vienna, Austria, 01130
Actively Recruiting
41
Medical Center Medconsult Pleven
Lovech, Bulgaria, 05500
Actively Recruiting
42
Medconsult Pleven
Pleven, Bulgaria, 05800
Actively Recruiting
43
Diagnostic-Consultative Centre Pulmed Eood
Plovdiv, Bulgaria, 04002
Actively Recruiting
44
Medical Center Prolet Eood
Rousse, Bulgaria, 07000
Actively Recruiting
45
Medical Center Unimed Eood
Sevlievo, Bulgaria, 05400
Actively Recruiting
46
Diagnostic-Consultative Center Ascendent Eood
Sofia, Bulgaria, 01202
Actively Recruiting
47
Diagnostic-Consultative Center Aleksandrovska Eood
Sofia, Bulgaria, 01431
Actively Recruiting
48
Dermatology Research Institute
Calgary, Alberta, Canada, T2J 7E1
Actively Recruiting
49
Rao Dermatology
Edmonton, Alberta, Canada, T6G 1C3
Actively Recruiting
50
Skin Physicians
Edmonton, Alberta, Canada, T6W 4V4
Actively Recruiting
51
Alpha Research-Lucere Dermatology and Laser Clinic
Edmonton, Alberta, Canada, T6X 0N9
Actively Recruiting
52
Park Dermatology
Sherwood Park, Alberta, Canada, T8H 0P1
Actively Recruiting
53
Simcoderm Medical and Surgical Dermatology Centre
Barrie, Ontario, Canada, L4M 7G1
Actively Recruiting
54
Skin Health
Cobourg, Ontario, Canada, K9A 0Z4
Actively Recruiting
55
Centricity Research London Victoria Multispecialty
London, Ontario, Canada, N6A 2C2
Actively Recruiting
56
Dermeffects
London, Ontario, Canada, N6H 5L5
Actively Recruiting
57
North York Research Inc.
Toronto, Ontario, Canada, M2N 3A6
Actively Recruiting
58
Toronto Research Centre
Toronto, Ontario, Canada, M3H 5Y8
Actively Recruiting
59
Centre de Recherche Dermatologique de Quebec
Québec, Quebec, Canada, G1V4X7
Actively Recruiting
60
Centre de Recherche Saint-Louis
Québec, Quebec, Canada, G1W 4R4
Actively Recruiting
61
Sima Recherche
Verdun, Quebec, Canada, H4G 3E7
Actively Recruiting
62
Skinsense Medical Research
Saskatoon, Saskatchewan, Canada, S7K 2C1
Actively Recruiting
63
Hopital Prive D Antony
Antony, France, 92160
Actively Recruiting
64
Hospital Morvan
Brest, France, 29200
Actively Recruiting
65
Cabinet Medical- Chemin de Paradis
Martigues, France, 13500
Not Yet Recruiting
66
Ghrmsa Hopital Emile Muller
Mulhouse, France, 68100
Completed
67
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hopital Hotel Dieu
Nantes, France, 44093
Actively Recruiting
68
Chu Paris-Gh St-Louis Lariboisiere F.Widal Hopital Saint-Louis
Paris, France, 75010
Actively Recruiting
69
Hopitaux Drome Nord - Site de Romans Sur Isere
Romans-sur-Isère, France, 26102
Actively Recruiting
70
Hopital Larrey
Toulouse, France, 31400
Actively Recruiting
71
Aachen University Hospital
Aachen, Germany, 52074
Not Yet Recruiting
72
Fachklinik Bad Bentheim
Bad Bentheim, Germany, 48455
Actively Recruiting
73
Hautzentrum Friedrichshain Studien
Berlin, Germany, 10247
Actively Recruiting
74
Charite Universitatsmedizin Berlin
Berlin, Germany, 12203
Actively Recruiting
75
Klinikum Dortmund Ggmbh
Dortmund, Germany, 44137
Actively Recruiting
76
Universitaetsklinik Und Poliklinik Fuer Dermatologie Und Venerologie
Halle, Germany, 06120
Actively Recruiting
77
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany, 20246
Actively Recruiting
78
Universitatsklinik Heidelberg
Heidelberg, Germany, 69115
Actively Recruiting
79
Universitaetsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
80
Universitaetsklinikum Schleswig-Holstein (Uksh) - Campus Luebeck
Lübeck, Germany, 23538
Actively Recruiting
81
Universitaetsmedizin Der Johannes - Gutenberg Universitaet Mainz
Mainz, Germany, 55131
Actively Recruiting
82
Universitaetsklinikum Giessen Und Marburg Gmbh
Marburg, Germany, 35043
Actively Recruiting
83
Universitaets-Hautklinik Eberhard-Karls-Universitaet Tuebingen
Tübingen, Germany, 72076
Actively Recruiting
84
Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele Ospedale Gaspare Rodolico Di Catania
Catania, Italy, 95123
Actively Recruiting
85
Clinical Research Centre - Cast
Chieti, Italy, 66013
Actively Recruiting
86
Azienda Sanitaria Locale 1 (Asl 1) - Ospedale Regionale San Salvatore
L’Aquila, Italy, 67100
Actively Recruiting
87
Uoc Dermatologia Ospedale Maggiore Policlinico, Fondazione Irccs Ca' Granda
Milan, Italy, 20122
Actively Recruiting
88
Aou Universita Della Campania Luigi Vanvitelli, Azienda Ospedaliero Universitaria Federico Ii Di Nap
Naples, Italy, 80131
Actively Recruiting
89
Azienda Ospedaliera Di Perugia
Perugia, Italy, 06129
Actively Recruiting
90
Azienda Ospedaliero Universitaria Pisana - Ospedale S. Chiara
Pisa, Italy, 56126
Actively Recruiting
91
Catholic University of the Sacred Heart
Rome, Italy, 00168
Actively Recruiting
92
Irccs Istituto Clinico Humanitas
Rozzano, Italy, 20089
Actively Recruiting
93
Amsterdam Universitair Medisch Centrum, Locatie Amsterdam Medisch Centrum
Amsterdam, Netherlands, 1105 AZ
Completed
94
Maxima Medisch Centrum
Veldhoven, Netherlands, 5504 DB
Completed
95
Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczny Osrodek Dermatologiczny Dermal
Bialystok, Poland, 15-453
Actively Recruiting
96
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Actively Recruiting
97
Gyncentrum Sp. Z O.O., Nzoz Holsamed- Oddzial Libero
Katowice, Poland, 40-600
Actively Recruiting
98
Pro Familia Altera Sp. Z O.O.
Katowice, Poland, 40-648
Completed
99
Centrum Badan Klinicznych, Jagiellonskie Centrum Innowacji Sp.Z.O.O.
Krakow, Poland, 30-348
Actively Recruiting
100
Diamond Clinic Sp. Z O.O.
Krakow, Poland, 31-559
Actively Recruiting
101
Niepubliczny Zaklad Opieki Zdrowotnej Med-Laser
Lublin, Poland, 20-406
Actively Recruiting
102
Mazowieckie Centrum Badan Klinicznych
Pruszków, Poland, 05-800
Actively Recruiting
103
Laser Clinic
Szczecin, Poland, 70-332
Actively Recruiting
104
Nzoz Gyncentrum - Oddzial Warszawa
Warsaw, Poland, 00-124
Actively Recruiting
105
Clinical Research Group Sp. Z.O.O
Warsaw, Poland, 01-142
Actively Recruiting
106
Centrum Medyczne Evimed
Warsaw, Poland, 02-625
Actively Recruiting
107
Klinika Ambroziak Sp. Z O.O.
Warsaw, Poland, 02-953
Actively Recruiting
108
Dermaceum Centrum Badan Klinicznych
Wroclaw, Poland, 53-613
Actively Recruiting
109
Penta Hospitals Przychodnie, Wroclaw Wejherowska
Wroclaw, Poland, 54-239
Actively Recruiting
110
Korea University Ansan Hospital
Ansan-si, South Korea, 15355
Actively Recruiting
111
Soon Chun Hyang University Bucheon Hospital
Bucheon-si, South Korea, 14584
Actively Recruiting
112
Pusan National University Hospital (Pnuh)
Busan, South Korea, 49241
Actively Recruiting
113
Pusan National University Yangsan Hospital
Busan, South Korea, 50612
Actively Recruiting
114
The Catholic University of Korea, Incheon St. Mary'S Hospital
Incheon, South Korea, 21431
Actively Recruiting
115
Jeonbuk National University Hospital
Jeonju, South Korea, 54907
Actively Recruiting
116
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
117
Konkuk University Medical Center
Seoul, South Korea, 05030
Completed
118
Inselspital Bern
Bern, Switzerland, 03010
Actively Recruiting
119
Dsc Clinic Buochs
Buochs, Switzerland, 06374
Actively Recruiting
120
Universitatsspital Zurich
Zurich, Switzerland, 08091
Actively Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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