Actively Recruiting
A Study to Evaluate the Efficacy and Safety of TL118 in Solid Tumors Patients
Led by Teligene US · Updated on 2026-04-28
60
Participants Needed
19
Research Sites
298 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective of the study will be to evaluate the efficacy of TL118 in participants with solid tumors harboring NTRK gene fusions
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety of TL118 in Solid Tumors Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years old and above, male or female
- Confirmed diagnosis of locally advanced or metastatic solid tumor with NTRK1/2/3 gene fusion producing a functional TRK kinase domain, without another onco-driver
- Disease progression after prior treatment, or unsuitable for standard care as judged by investigator; prior TRK inhibitor treatment allowed only if less than 28 days due to toxicity
- At least one measurable lesion
- ECOG performance status of 0, 1, or 2
- Minimum life expectancy greater than 3 months
- Adequate bone marrow, liver, kidney, and coagulation functions
- Other inclusion criteria as per study protocol
You will not qualify if you...
- Systemic anti-tumor therapy (chemotherapy, radiation including curative or spinal >30%) within 3 weeks before enrollment; immunotherapy within 4 weeks; palliative radiotherapy or traditional Chinese medicines for tumor within 2 weeks
- Participation in another interventional trial within 2 weeks or within 5 half-lives of last investigational product dose
- Unresolved toxicities from prior therapy greater than Grade 1, except those posing no safety risk
- Active central nervous system metastases
- Other primary malignant tumors within 3 years, except cured skin basal cell carcinoma or in situ cervix cancer of low risk
- Active uncontrolled infection
- Other exclusion criteria as per study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
Adventist Health Glendale
Glendale, California, United States, 91206
Actively Recruiting
2
Texas Oncology
Dallas, Texas, United States, 75251
Actively Recruiting
3
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
4
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
5
Peking University School and Hospital of Stomatology
Beijing, Beijing Municipality, China
Actively Recruiting
6
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Actively Recruiting
7
Fujian Cancer Hospital
Fuzhou, Fujian, China
Actively Recruiting
8
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, Guangdong, China
Actively Recruiting
9
Harbin medical university cancer hospital
Harbin, Heilongjiang, China
Actively Recruiting
10
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
11
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
12
Hunan Cancer Hospital
Changsha, Hunan, China
Actively Recruiting
13
Jiangxi Cancer Hospital
Nanchang, Jiangxi, China
Actively Recruiting
14
Shanxi Cancer Hospital
Xi'an, Shaanxi, China
Actively Recruiting
15
Jinan Central Hospital
Jinan, Shandong, China
Actively Recruiting
16
Shanghai East Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
17
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Actively Recruiting
18
Affiliated Cancer Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
Actively Recruiting
19
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
X
Xiaoyang Xia
CONTACT
D
Dawei Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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