Actively Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Led by Celgene · Updated on 2026-05-07
200
Participants Needed
54
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986368 in participants with Multiple Sclerosis Spasticity
CONDITIONS
Official Title
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have a multiple sclerosis (MS) diagnosis.
- Participants must have a history of spasticity due to MS for at least 6 months prior to Visit 1.
- Participants must have a Modified Ashworth Scale (mAS) score 62;2 in each of 2 muscle groups (at least one muscle group in the leg, excluding ankle plantar flexors) at Visit 1.
- Participants must have an Expanded Disability Status Scale (EDSS) score 3.0-6.5 at Visit 1.
You will not qualify if you...
- Participants must not have any concomitant disease or disorder that has symptoms of spasticity or that may influence the participant's level of spasticity.
- Participants must not have an acute MS exacerbation/relapse requiring treatment or alteration in disease modifying drug dose within 3 months of Visit 1 or Visit 2.
- Participants must not have a history of any substance abuse disorder as defined in DSM-5 Diagnostic Criteria for Drug and Alcohol Abuse.
- Participants must not be currently taking a medication for spasticity that cannot be discontinued and washed out by Visit 2.
- Participants must not have used FAAH/MAGL inhibitor medication or any cannabinoid-related products (including cannabis, cannabidiol (CBD), or tetrahydrocannabinol (THC)) within 30 days prior to Visit 1.
- Other protocol-defined Inclusion/Exclusion criteria apply.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 54 locations
1
Alabama Neurology Associates
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
Perseverance Research Center,LLC
Scottsdale, Arizona, United States, 85253
Actively Recruiting
3
Local Institution - 0017
Aurora, Colorado, United States, 80045
Withdrawn
4
Aqualane Clinical Research
Naples, Florida, United States, 34105
Actively Recruiting
5
USF Health
Tampa, Florida, United States, 33612
Actively Recruiting
6
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
7
Neurology Center of New England
Foxborough, Massachusetts, United States, 02035
Actively Recruiting
8
Local Institution - 0071
Southfield, Michigan, United States, 48034
Not Yet Recruiting
9
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
10
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
11
Local Institution - 0039
Columbus, Ohio, United States, 43214
Not Yet Recruiting
12
Local Institution - 0069
Columbus, Ohio, United States, 43235
Withdrawn
13
Local Institution - 0067
Philadelphia, Pennsylvania, United States, 19107
Not Yet Recruiting
14
Hope Neurology
Knoxville, Tennessee, United States, 37922
Actively Recruiting
15
EvergreenHealth Medical Center
Kirkland, Washington, United States, 98034
Actively Recruiting
16
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
17
University of Sydney - Brain and Mind Research Institute (BMRI)
Sydney, New South Wales, Australia, 2050
Actively Recruiting
18
Centre for Neuroscience Innovation
Kent Town, South Australia, Australia, 5067
Actively Recruiting
19
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Actively Recruiting
20
Austin Health
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
21
The Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
22
Perron Institute
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
23
University Of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2G3
Actively Recruiting
24
University Hospital - London Health Sciences Centre
London, Ontario, Canada, N6A 5A5
Actively Recruiting
25
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
26
Local Institution - 0028
Toronto, Ontario, Canada, M5B 1W8
Not Yet Recruiting
27
Centre de Recherche Saint-Louis
Lévis, Quebec, Canada, G6W0M5
Actively Recruiting
28
Montreal Neurological Institute and Hospital
Montreal, Quebec, Canada, H3A2B4
Actively Recruiting
29
Fakultni Nemocnice u sv. Anny v Brne
Brno, Brno-město, Czechia, 656 91
Actively Recruiting
30
Fakultni nemocnice Hradec Kralove
Hradec Králové, Hradec Králové, Czechia, 500 05
Actively Recruiting
31
Vseobecna fakultni nemocnice v Praze
Prague, Praha 2, Czechia, 12111
Actively Recruiting
32
Fakultni Thomayerova nemocnice
Prague, Praha 4, Czechia, 14059
Actively Recruiting
33
Local Institution - 0011
Prague, Praha 5, Czechia, 150 06
Withdrawn
34
Nemocnice Pardubického kraje
Pardubice, Czechia, 532 03
Actively Recruiting
35
Nemocnice Teplice
Teplice, Ústí nad Labem Region, Czechia, 415 01
Actively Recruiting
36
Klinikum Würzburg Mitte
Würzburg, Bavaria, Germany, 97074
Actively Recruiting
37
Neurologischen Gemeinschaftspraxis Kassel und Vellmar
Kassel, Hesse, Germany, 34121
Actively Recruiting
38
St. Josef und St. Elisabeth Hospital gGmbH
Bochum, North Rhine-Westphalia, Germany, 44791
Actively Recruiting
39
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, North Rhine-Westphalia, Germany, 48149
Actively Recruiting
40
Local Institution - 0031
Meisenheim, Rhineland-Palatinate, Germany, 55590
Withdrawn
41
Universitätsklinikum Jena
Jena, Thuringia, Germany, 07747
Actively Recruiting
42
Neurozentrum Bielefeld
Bielefeld, Germany, 33647
Actively Recruiting
43
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Actively Recruiting
44
Local Institution - 0020
Essen, Germany, 45122
Withdrawn
45
Centrum Medyczne NEUROMED
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-163
Actively Recruiting
46
Local Institution - 0044
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-796
Not Yet Recruiting
47
Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, Poland, 30-727
Actively Recruiting
48
SP ZOZ Szpital Uniwersytecki w Krakowie
Krakow, Lesser Poland Voivodeship, Poland, 31-503
Actively Recruiting
49
Instytut Zdrowia Dr Boczarska Jedynak
Oświęcim, Lesser Poland Voivodeship, Poland, 32-600
Actively Recruiting
50
Centrum Medyczne NeuroProtect
Warsaw, Masovian Voivodeship, Poland, 01-684
Actively Recruiting
51
Local Institution - 0061
Gdansk, Poland, 80-952
Withdrawn
52
M.A. - LEK A.M. Maciejowscy S.C., Centrum Terapii SM
Katowice, Poland, 40-571
Actively Recruiting
53
Local Institution - 0051
Słomniki, Poland, 32-090
Withdrawn
54
Puerto Rico Multiple Sclerosis Center
Caguas, Puerto Rico, 00725
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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