Actively Recruiting
A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis
Led by Renibus Therapeutics, Inc. · Updated on 2026-04-22
150
Participants Needed
16
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this 26 week study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD) and metabolic acidosis.
CONDITIONS
Official Title
A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent is provided.
- Adults 18 years old or older, male or female.
- Diagnosed with chronic kidney disease with eGFR less than 60 mL/min/1.73m² and not expected to need dialysis or transplant during the study.
- Two serum bicarbonate values between 12 and 21 mmol/L within 6 months before screening.
- During screening, two central serum bicarbonate values between 12 and 21 mmol/L.
- Willingness to maintain a stable diet.
- Expectation to keep oral alkali therapy dose stable.
- Women of childbearing potential must have a negative pregnancy test and agree to abstinence or use contraception.
You will not qualify if you...
- Considered inappropriate for physical performance testing (e.g., severe musculoskeletal pain, non-ambulatory) or have a screening Sit-to-Stand 5 times test time less than 10 seconds.
- Considered inappropriate for cardiopulmonary exercise testing (CPET) due to conditions like advanced COPD, recent major cardiovascular event, or very high blood pressure.
- History or current diagnosis of significant gastrointestinal disorders such as gastroparesis, bariatric surgery, bowel obstruction, swallowing disorders, inflammatory bowel disease, major gastrointestinal surgery, or active gastric/duodenal ulcers.
- Severe recurrent diarrhea or constipation.
- Diagnosed with pernicious anemia, atrophic or autoimmune gastritis, achlorhydria, or hypochlorhydria.
- Active Helicobacter pylori infection at screening.
- Active, recurrent, or metastatic cancer at screening.
- History of certain malignancies not meeting specific remission or treatment criteria.
- Evidence or history of acute or recurrent fluid overload.
- Screening hemoglobin less than 10 g/dL.
- Presence of primary respiratory alkalosis.
- Serum gastrin level greater than 500 pg/mL.
- Use of investigational medication within 28 days before screening.
- Use or planned use of certain gastrointestinal binders or acid-reducing drugs within 28 days before screening.
- Use or planned use of GLP-1 inhibitors within 6 months before screening.
- Unstable use or planned changes of specific medications including diuretics, carbonic anhydrase inhibitors, diabetes drugs, RAAS inhibitors, supplements, phosphate binders, and SGLT-2 inhibitors.
- Taking more than 30 units of insulin daily.
- History of alcoholism or drug abuse within 1 year before screening.
- Current regular use of cannabis/THC products.
- Inability to take study medication or comply with protocol.
- Any medical condition or uncontrolled disease that could reduce study compliance or participant safety as judged by the Investigator.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
California Institute of Renal Research
Chula Vista, California, United States, 91910
Actively Recruiting
2
Academic Medical Research Institute
Los Angeles, California, United States, 90022
Actively Recruiting
3
UC Davis Health, Dept of Internal Medicine
Sacramento, California, United States, 95817
Actively Recruiting
4
Velocity Clinical Research
Edgewater, Florida, United States, 32132
Actively Recruiting
5
Belkis Delgado MD PA
Miami Springs, Florida, United States, 33166
Actively Recruiting
6
ClinTrial Research - Oakwater
Orlando, Florida, United States, 32806
Actively Recruiting
7
Southeastern Clinical Research Institute
Augusta, Georgia, United States, 30904
Actively Recruiting
8
CARE Institute - Boise Kidney
Boise, Idaho, United States, 83706
Actively Recruiting
9
Idaho Kidney - CARE Institute
Chubbuck, Idaho, United States, 83201
Actively Recruiting
10
CARE Institute - Idaho Falls
Idaho Falls, Idaho, United States, 83401
Actively Recruiting
11
Research by Design
Chicago, Illinois, United States, 60643
Actively Recruiting
12
Indiana University School of Medicine
Indianapolis, Indiana, United States, 46202
Actively Recruiting
13
Nephrology Associates of Kentuckiana
Louisville, Kentucky, United States, 40205
Actively Recruiting
14
New York-Presbyterian Queens
Fresh Meadows, New York, United States, 11365
Actively Recruiting
15
Brookview Hills Research Associates
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
16
Clinical Advancement Center
San Antonio, Texas, United States, 78212
Actively Recruiting
Research Team
A
Ayla Rasmussen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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