Actively Recruiting
A Decentralized, Randomized Interventional Study to Evaluate the Impact of an Over-the-Counter Magnolia Officinalis Oral Supplement on Blood Biomarkers of Immune Activation in Subjects With Psoriasis
Led by Sirt3 LLC · Updated on 2026-03-13
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
S
Sirt3 LLC
Lead Sponsor
P
People Science, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether Viv, a consumer-grade dietary supplement made from Magnolia officinalis bark extract, affects immune activity markers in adults with psoriasis. This clinical trial compares Viv to a placebo to understand its impact on inflammation-related proteins. Participants have stable psoriasis confirmed by a dermatologist and may have related conditions like psoriatic arthritis if not requiring systemic treatments. Participants will be randomly assigned to take either Viv, containing 200 mg of Magnolia officinalis bark extract, or a placebo daily for three months. The study is triple-blinded, meaning neither the participants nor researchers know who receives which treatment. Participants will use the supplement at home and collect blood samples themselves at the start, after one month, and after three months using provided kits. During the study, participants will complete electronic questionnaires about their psoriasis symptoms and quality of life at the beginning, one month, and three months. Researchers will analyze blood samples to measure changes in inflammatory proteins and immune cells over time. The primary outcome is the change in plasma Beta defensin 2 levels after 12 weeks. The total study period for participants is three months, with ongoing safety and adherence monitored remotely.
CONDITIONS
Brief Title
A Study to Evaluate the Impact of a Magnolia Officinalis Dietary Supplement on Immune Biomarkers in Subjects With Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older at time of consent
- Diagnosis of stable psoriasis confirmed by a dermatologist for at least 6 months
- Patients with psoriasis-associated comorbidities including psoriatic arthritis permitted if not requiring systemic therapies
- Able to read and understand English
- Able to provide informed consent
- Able to use a personal smartphone and download the Chloe app
- Able to receive shipment of the study product within the United States
- Willing and able to adhere to the study protocol including blood sample collection and shipping
You will not qualify if you...
- No access to a personal smartphone or unwilling to download the Chloe app
- Use of systemic non-biologic immunosuppressive agents within 8 weeks prior to randomization
- Use of systemic biologic therapies within 6 months prior to randomization
- Use of other systemic investigational drugs within 6 months prior to randomization
- Currently pregnant, planning to become pregnant in next 3 months, or breastfeeding
- Medical conditions that may affect digestive symptom assessment or study outcomes
- Significant illness or condition that may impact study participation or outcomes
- Known allergy or hypersensitivity to magnolia, rice, or hypromellose
- Unlikely to comply with study requirements or deemed unsuitable by the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote or in-person) to confirm eligibility and consent
Duration - 12 weeks
Participants take either a dietary supplement containing Magnolia officinalis bark extract or a placebo daily.
Weekly remote check-ins with blood sample collection and symptom reporting
Trial Site Locations
Total: 1 location
1
Decentralized Study Coordinating Center
Englewood, New Jersey, United States, 07631
Actively Recruiting
Research Team
A
Adeeb Rahman, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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