Actively Recruiting
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Led by Incyte Corporation · Updated on 2026-05-08
466
Participants Needed
162
Research Sites
178 weeks
Total Duration
On this page
Sponsors
I
Incyte Corporation
Lead Sponsor
E
ENGOT Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression.
CONDITIONS
Official Title
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological diagnosis of high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer.
- Have platinum-resistant disease.
- Participants with 1 line of platinum-based therapy must have received at least 4 cycles of platinum.
- Participants with 2 to 4 lines of platinum-based therapy must have progressed on or within 6 months after last platinum dose.
- Archival tumor tissue block or slides no older than 5 years must be available or willingness for pretreatment biopsy.
- Received between 1 and 4 prior lines of systemic therapy after initial diagnosis.
- Prior treatment with bevacizumab unless contraindicated.
- Prior treatment with mirvetuximab soravtansine if tumor is FRα positive unless medically exempt.
- Measurable disease per RECIST v1.1.
You will not qualify if you...
- Have endometrioid, clear cell, mucinous, or sarcomatous histology, mixed tumors with these histologies, or low-grade/borderline ovarian cancer.
- Have primary platinum-refractory disease (progression on or within 3 months after first line platinum therapy).
- Clinically significant or uncontrolled cardiac disease within 6 months before first dose.
- Known active CNS metastases or carcinomatous meningitis.
- Known progressing additional malignancy or history of other malignancy within 3 years before first dose.
- Clinically significant gastrointestinal abnormalities.
- Other protocol-defined inclusion/exclusion criteria may apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 162 locations
1
Alaska Womens Cancer Care Akwcc
Anchorage, Alaska, United States, 99508
Not Yet Recruiting
2
City of Hope Medical Center
Duarte, California, United States, 91010
Not Yet Recruiting
3
Valkyrie Clinical Trials
Los Angeles, California, United States, 90067
Actively Recruiting
4
University of Colorado Cancer Center
Aurora, Colorado, United States, 80045
Not Yet Recruiting
5
Georgia Cancer Center
Augusta, Georgia, United States, 30912
Not Yet Recruiting
6
Carle Cancer Center
Effingham, Illinois, United States, 62401-2006
Not Yet Recruiting
7
Northshore University Health System-Evanston Hospital
Evanston, Illinois, United States, 60201
Not Yet Recruiting
8
Women'S Cancer Care
Covington, Louisiana, United States, 70433
Not Yet Recruiting
9
Maine Center For Cancer Medicine
Scarborough, Maine, United States, 04074
Not Yet Recruiting
10
Holy Cross Hospital
Silver Spring, Maryland, United States, 20910
Not Yet Recruiting
11
Mercy Hospital St. Louis - David C. Pratt Cancer Center
St Louis, Missouri, United States, 63141
Not Yet Recruiting
12
Billings Clinic
Billings, Montana, United States, 59101
Actively Recruiting
13
Center of Hope
Reno, Nevada, United States, 89502
Not Yet Recruiting
14
Levine Cancer Center
Charlotte, North Carolina, United States, 28204
Not Yet Recruiting
15
Novant Presbyterian Hospital
Charlotte, North Carolina, United States, 28204
Not Yet Recruiting
16
Novant Health Oncology Specialists
Winston-Salem, North Carolina, United States, 27103
Not Yet Recruiting
17
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States, 27157
Not Yet Recruiting
18
Oncology Associates of Oregon, P.C.
Eugene, Oregon, United States, 97401
Not Yet Recruiting
19
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Not Yet Recruiting
20
University of Pittsburgh Cancer Institute Cancer Services
Pittsburgh, Pennsylvania, United States, 15213
Not Yet Recruiting
21
Wellspan Gynecologic Oncology
York, Pennsylvania, United States, 17403
Not Yet Recruiting
22
Sanford Cancer Center-Sioux Falls
Sioux Falls, South Dakota, United States, 57104-8805
Not Yet Recruiting
23
Erlanger Health, Inc.
Chattanooga, Tennessee, United States, 37403
Actively Recruiting
24
Texas Oncology-Abilene
Abilene, Texas, United States, 79606
Not Yet Recruiting
25
Inova Schar Cancer Institute
Fairfax, Virginia, United States, 22031
Not Yet Recruiting
26
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Not Yet Recruiting
27
Chris O'Brien Lifehouse Hospital
Camperdown, New South Wales, Australia, 02050
Not Yet Recruiting
28
North Coast Cancer Institute
Port Macquarie, New South Wales, Australia, 02444
Withdrawn
29
The Wollongong Hospital
Wollongong, New South Wales, Australia, 02500
Not Yet Recruiting
30
Icon Cancer Care - Townsville
Townsville, Queensland, Australia, 04812
Not Yet Recruiting
31
Eastern Health-Box Hill Hospital
Box Hill, Victoria, Australia, 03128
Not Yet Recruiting
32
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
Brussels, Belgium, 01070
Not Yet Recruiting
33
Cliniques Universitaires St Luc Ucl
Brussels, Belgium, B-1200
Not Yet Recruiting
34
Az Maria Middelares Gent
Ghent, Belgium, 09000
Not Yet Recruiting
35
UZ GENT
Ghent, Belgium, 09000
Not Yet Recruiting
36
Az Groeninge
Kortrijk, Belgium, 08500
Not Yet Recruiting
37
Universitair Ziekenhuis Leuven
Leuven, Belgium, 03000
Not Yet Recruiting
38
Tom Baker Cancer Center-Alberta Health Services (Ahs) - University of Calgary
Calgary, Alberta, Canada, T2N 4N2
Not Yet Recruiting
39
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Not Yet Recruiting
40
British Columbia Cancer Agency (Bcca) - Abbotsford Regional Hospital and Cancer Centre (Arhcc)
Abbotsford British Columbia, British Columbia, Canada, V2S 0C2
Withdrawn
41
Bc Cancer Vancouver
Vancouver, British Columbia, Canada, V5Z 1L3
Withdrawn
42
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Not Yet Recruiting
43
Sunnybrook Health Science Centre
Toronto, Ontario, Canada, M4N 3M5
Withdrawn
44
University Health Network (Uhn) - Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Not Yet Recruiting
45
Sir Mortimer B. Davis - Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Not Yet Recruiting
46
Cedars Cancer Centre - McGill University Health Centre (Muhc) - Glen Site
Montreal, Quebec, Canada, H4A 3J1
Not Yet Recruiting
47
Trillium Health Partners - Credit Valley Hospital
Mississauga, Canada, L5M 2N1
Not Yet Recruiting
48
Ch Davignon - Hopital Henri Duffaut
Avignon, France, 84902
Not Yet Recruiting
49
Clinique Tivoli
Bordeaux, France, 33000
Not Yet Recruiting
50
Clinique Pole Sante Leonard de Vinci
Chambray-lès-Tours, France, 37170
Not Yet Recruiting
51
Centre Hospitalier Departemental de Vendee, Hopital de La-Roche-Sur-Yon Les Oudairies
La Roche-sur-Yon, France, 85925
Not Yet Recruiting
52
Centre Hospitalier Universitaire de Grenoble- Hopital Albert Michallon
La Tronche, France, 38700
Not Yet Recruiting
53
Hopital Prive Jean Mermoz
Lyon, France, 69008
Not Yet Recruiting
54
Institut Paoli Calmettes
Marseille, France, 13009
Not Yet Recruiting
55
Centre Antoine Laccassagne
Nice, France, 06189
Not Yet Recruiting
56
Tenon - Aphp
Paris, France, 75020
Not Yet Recruiting
57
Centre Eugene Marquis
Rennes, France, 35042
Not Yet Recruiting
58
Hopital de Hautepierre
Strasbourg, France, 67098
Not Yet Recruiting
59
Institut Gustave Roussy-Gustave Roussy Cancer Center -Ditep
Villejuif, France, 94805
Not Yet Recruiting
60
Universitätsklinikum Bonn
Bonn, Germany, 53127
Not Yet Recruiting
61
University Clinic Carl Gustav Carus Technical University Dresden
Dresden, Germany, 01307
Not Yet Recruiting
62
Vidia Christliche Kliniken Karlsruhe
Karlsruhe, Germany, 76135
Withdrawn
63
Klinikum Kassel
Kassel, Germany, 34125
Not Yet Recruiting
64
Universitatsklinikum Schleswig Holstein
Kiel, Germany, 24105
Not Yet Recruiting
65
Universitätsmedizin Mannheim
Mannheim, Germany, 68167
Not Yet Recruiting
66
Johannes Wesling Klinikum Minden
Minden, Germany, 32429
Not Yet Recruiting
67
Lmu - Klinikum Der Universitaet Muenchen - Campus Grosshadern
München, Germany, 81377
Not Yet Recruiting
68
Universitaetsklinikum Tuebingen (Ukt)
Tübingen, Germany, 72076
Not Yet Recruiting
69
Universitätsklinikum Ulm
Ulm, Germany, 89075
Not Yet Recruiting
70
St. Vincent'S University Hospital
Dublin, Ireland, D04 Y8V0
Not Yet Recruiting
71
Mater Misericordiae University Hospital
Dublin, Ireland, D07 R2WY
Not Yet Recruiting
72
St. James Hospital
Dublin, Ireland, D08 NHY1
Not Yet Recruiting
73
University Hospital Waterford
Waterford, Ireland, X91 ER8E
Not Yet Recruiting
74
Azienda Ospedaliero-Universitaria Di Alessandria Ss.Antonio E Biagio E Cesare Arrigo
Alessandria, Italy, 15121
Withdrawn
75
Ss Antonio & Biagio and C. Arrigo Hospital
Alessandria, Italy, 15121
Not Yet Recruiting
76
Centro Di Riferimento Oncologico Di Aviano
Aviano, Italy, 33081
Not Yet Recruiting
77
Azienda Ospedaliero-Universitaria Orsola-Malpighi - Universita Degli Studi Di Bologna
Bologna, Italy, 40138
Not Yet Recruiting
78
Ospedale Careggi
Florence, Italy, 50134
Not Yet Recruiting
79
Azienda Socio Santaria Territoriale de Lecco - Ospedale A. Manzoni
Lecco, Italy, 23900
Not Yet Recruiting
80
Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) - Ospedale San Raffaele (Hsr) (Istituto
Milan, Italy, 20132
Not Yet Recruiting
81
Fondazione Irccs Istituto Nazionale Dei Tumori
Milan, Italy, 20133
Not Yet Recruiting
82
Humanitas San Pio X
Milan, Italy, 20159
Not Yet Recruiting
83
Azienda Ulss 3 Serenissima - Ospedale Di Mirano
Mirano, Italy, 30035
Not Yet Recruiting
84
Istituto Nazionale Tumori Irccs Fondazione Pascale
Naples, Italy, 80131
Not Yet Recruiting
85
Comitato Etico Irccs Istituto Oncologico Veneto Di Padova
Padova, Italy, 35128
Not Yet Recruiting
86
Universita Degli Studi Di Pavia-Fondazione Irccs Policlinico San Matteo
Pavia, Italy, 27100
Not Yet Recruiting
87
Ausl Di Placenza Ospedale Guglielmo Da Saliceto
Placenza, Italy, 29121
Not Yet Recruiting
88
Ospedale Santa Maria Delle Croci
Ravenna, Italy, 48121
Not Yet Recruiting
89
Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena (Ire)
Rome, Italy, 00144
Not Yet Recruiting
90
Fondazione Policlinico Universitario Agostino Gemelli Irccs - Universita Cattolica Del Sacro Cuore
Rome, Italy, 00168
Not Yet Recruiting
91
Ordine Mauriziano - Ospedale Umberto I Di Torino
Torino, Italy, 10128
Not Yet Recruiting
92
Ospedale Ca' Foncello
Treviso, Italy, 31100
Not Yet Recruiting
93
Azienda Sanitaria Universitaria Friuli Centrale Asu Fc
Udine, Italy, 33100
Not Yet Recruiting
94
Ospedale Ferrero
Verduno, Italy, 12060
Not Yet Recruiting
95
Hyogo Cancer Center
Akashi-shi, Japan, 673-8558
Not Yet Recruiting
96
Saitama Medical University International Medical Center
Hidaka-shi, Japan, 350-1298
Not Yet Recruiting
97
The Cancer Institute Hospital of Jfcr
Kōtoku, Japan, 135-8550
Not Yet Recruiting
98
Kurume University Hospital
Kurume, Japan, 830-0011
Not Yet Recruiting
99
Nho Shikoku Cancer Center
Matsuyama, Japan, 791-0280
Not Yet Recruiting
100
The Jikei University Hospital
Minatoku, Japan, 105-8471
Actively Recruiting
101
Aichi Cancer Center
Nagoya, Japan, 464-8681
Not Yet Recruiting
102
Okayama University Hospital
Okayama, Japan, 700-8558
Actively Recruiting
103
Osaka International Cancer Institute
Osaka, Japan, 541-8567
Actively Recruiting
104
Sapporo Medical University Hospital
Sapporo, Japan, 060-8543
Actively Recruiting
105
Hokkaido University Hospital
Sapporo, Japan, 060-8648
Not Yet Recruiting
106
Tohoku University Hospital
Sendai, Japan, 980-8574
Actively Recruiting
107
Iwate Medical University Hospital
Shiwa-gun, Japan, 028-3695
Not Yet Recruiting
108
Shizuoka Cancer Center
Sunto-gun, Japan, 411-8777
Not Yet Recruiting
109
National Cancer Center Hospital
Tokyo, Japan, 104-0045
Not Yet Recruiting
110
Nki-Avl (Nederlands Kanker Instituut-Anthonie Van Leeuwenhoek)
Amsterdam, Netherlands, 1066 CX
Not Yet Recruiting
111
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ
Not Yet Recruiting
112
Radboud University Medical Center
Nijmegen, Netherlands, 6525 GA
Not Yet Recruiting
113
Erasmus Medisch Centrum 1
Rotterdam, Netherlands, 3015 GD
Not Yet Recruiting
114
Universitair Medisch Centrum Utrecht (Umc Utrecht)
Utrecht, Netherlands, 3584 CX
Not Yet Recruiting
115
Uniwersyteckie Centrum Onkologii
Bialystok, Poland, 15-276
Not Yet Recruiting
116
Gdanski Uniwersytet Medyczny
Gdansk, Poland, 80-214
Not Yet Recruiting
117
Swietokrzyskie Centrum Onkologii Spzoz
Kielce, Poland, 25-734
Not Yet Recruiting
118
Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii
Siedlce, Poland, 08-110
Not Yet Recruiting
119
Uniwersytecki Szpital Kliniczny Nr 2 Pomorskiego Uniwersytetu Medycznego W Szczecinie
Szczecin, Poland, 70-111
Not Yet Recruiting
120
Samsung Changwon Hospital
Changwon-si, South Korea, 51353
Not Yet Recruiting
121
National Cancer Center
Goyang-si, South Korea, 10408
Not Yet Recruiting
122
Cha University Bundang Cha Medical Center
Seongnam-si, South Korea, 13520
Not Yet Recruiting
123
Seoul National University Bundang Hospital (Snubh)
Seongnam-si, South Korea, 13620
Not Yet Recruiting
124
Korea University Anam Hospital
Seoul, South Korea, 02841
Not Yet Recruiting
125
Seoul National University Hospital
Seoul, South Korea, 03080
Not Yet Recruiting
126
Konkuk University Medical Center
Seoul, South Korea, 05030
Not Yet Recruiting
127
Asan Medical Center
Seoul, South Korea, 05505
Not Yet Recruiting
128
Samsung Medical Center
Seoul, South Korea, 06351
Not Yet Recruiting
129
Seoul St. Mary'S Hospital
Seoul, South Korea, 06591
Not Yet Recruiting
130
Ewha Womans University Mokdong Hospital
Seoul, South Korea, 07985
Not Yet Recruiting
131
Hospital Universitario de Alava
Alava, Spain, 01009
Not Yet Recruiting
132
Ico-Badalona
Badalona, Spain, 89016
Not Yet Recruiting
133
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Not Yet Recruiting
134
Clinica Universidad de Navarra
Madrid, Spain, 28022
Not Yet Recruiting
135
Hospital Universitario La Paz
Madrid, Spain, 28046
Not Yet Recruiting
136
Hospital Universitario Virgen de La Victoria
Málaga, Spain, 29010
Not Yet Recruiting
137
Hospital Universitario Central de Asturias
Oviedo, Spain, 33011
Not Yet Recruiting
138
Hospital Son Espases. Mallorca
Palma de Mallorca, Spain, 07120
Not Yet Recruiting
139
Corporacio Sanitaria Universitaria Parc Tauli
Sabadell, Spain, 08208
Not Yet Recruiting
140
Hospital Universitario Virgen Del Rocío Sevilla
Seville, Spain, 41013
Not Yet Recruiting
141
Hospital Universitario Virgen de Valme
Seville, Spain, 41014
Not Yet Recruiting
142
Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva)
Valencia, Spain, 46010
Not Yet Recruiting
143
Ospedale Regionale Di Bellinzona
Bellinzona, Switzerland, 06500
Not Yet Recruiting
144
Kantonsspital Graubunden
Chur, Switzerland, 07000
Not Yet Recruiting
145
Kantonsspital Frauenfeld
Frauenfeld, Switzerland, 08501
Not Yet Recruiting
146
Hopitaux Universitaires de Geneve (Hug) (Hopital Cantonal)
Geneva, Switzerland, 01205
Not Yet Recruiting
147
Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit
Lausanne, Switzerland, 01011
Not Yet Recruiting
148
University Hospital of Zurich
Zurich, Switzerland, 08032
Not Yet Recruiting
149
Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
Cambridge, United Kingdom, CB2 0QQ
Not Yet Recruiting
150
Velindre Nhs Trust, Velindre Cancer Centre
Cardiff, United Kingdom, CF14 2TL
Not Yet Recruiting
151
Edinburgh Cancer Centre Western General Hospital
Edinburgh, United Kingdom, EH4 2XU
Withdrawn
152
Royal Surrey County Hospital - Royal Surrey County Hospital Nhs Foundation Trust
Guildford, United Kingdom, GU2 7XX
Not Yet Recruiting
153
St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
Leeds, United Kingdom, LS9 7TF
Not Yet Recruiting
154
Clatterbridge Cancer Center
Liverpool, United Kingdom, L7 8YA
Not Yet Recruiting
155
University College London Hospitals - University College London Hospitals Nhs Foundation Trust
London, United Kingdom, NW1 2BU
Not Yet Recruiting
156
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
London, United Kingdom, SE1 9RT
Not Yet Recruiting
157
Hammersmith Hospital - Imperial College Healthcare Nhs Trust
London, United Kingdom, W12 0HS
Not Yet Recruiting
158
The Christie Nhs Foundation Trust
Manchester Greater, United Kingdom, M204BX
Not Yet Recruiting
159
Northampton General Hospital - Northampton General Hospital Nhs Trust
Northampton, United Kingdom, NN1 5BD
Not Yet Recruiting
160
Mount Vernon Cancer Centre
Northwood, United Kingdom, HA6 2RN
Not Yet Recruiting
161
Royal Marsden Hospital
Sutton, United Kingdom, SM2 5PT
Not Yet Recruiting
162
Musgrove Park Hospital - Somerset Nhs Foundation Trust
Taunton, United Kingdom, TA1 5DA
Not Yet Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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