Actively Recruiting

Phase 3
Age: 5Years - 17Years
All Genders
NCT07424404

A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

Led by Karuna Therapeutics, Inc., a Bristol Myers Squibb company · Updated on 2026-05-11

400

Participants Needed

59

Research Sites

204 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to evaluate the long-term safety and tolerability of KarXT and KarX-EC for the treatment of Schizophrenia and autism-related irritability in adolescents, respectively

CONDITIONS

Official Title

A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

Who Can Participate

Age: 5Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants must have completed the double-blind treatment period of Study CN0120020 or Studies CN0120044 or CN0120045 without an adverse event that could indicate an unacceptable safety risk according to the investigator.
Not Eligible

You will not qualify if you...

  • Participants with significant risk of violent acts, serious self-harm, or recent suicidal ideation based on history or psychiatric evaluation are excluded.
  • Participants with homicidal behavior or considered high risk to others are excluded.
  • Participants with any clinically significant abnormality in physical exam, vital signs, or ECG at the end of prior related studies that jeopardizes safety are excluded.
  • Participants with systolic or diastolic blood pressure meeting stage 2 hypertension criteria are excluded.
  • Other protocol-defined inclusion or exclusion criteria apply.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 59 locations

1

Local Institution - 0077

Anaheim, California, United States, 92805

Not Yet Recruiting

2

Local Institution - 0058

Chino, California, United States, 91710

Not Yet Recruiting

3

Local Institution - 0024

Culver City, California, United States, 90230

Not Yet Recruiting

4

Local Institution - 0083

Redlands, California, United States, 92373

Not Yet Recruiting

5

Local Institution - 0089

San Francisco, California, United States, 94158

Not Yet Recruiting

6

Apg Research, Llc

Orlando, Florida, United States, 32803

Actively Recruiting

7

Atlanta Center for Medical Research

Atlanta, Georgia, United States, 30331

Actively Recruiting

8

Salveo Integrative Health - Lawrenceville

Lawrenceville, Georgia, United States, 30046

Actively Recruiting

9

Local Institution - 0039

Stone Mountain, Georgia, United States, 30083

Not Yet Recruiting

10

EmVenio Research Center - Prime Healthcare

Chicago, Illinois, United States, 60622

Actively Recruiting

11

Local Institution - 0076

Boston, Massachusetts, United States, 02115

Not Yet Recruiting

12

Local Institution - 0059

Worcester, Massachusetts, United States, 01608

Not Yet Recruiting

13

Local Institution - 0061

Great Neck, New York, United States, 11021

Not Yet Recruiting

14

University of Cincinnati Cancer Institute

Cincinnati, Ohio, United States, 45219

Actively Recruiting

15

Local Institution - 0097

Philadelphia, Pennsylvania, United States, 19139

Not Yet Recruiting

16

Local Institution - 0137

Nashville, Tennessee, United States, 37212

Not Yet Recruiting

17

Local Institution - 0046

Garland, Texas, United States, 75043

Not Yet Recruiting

18

Local Institution - 0066

Spring, Texas, United States, 77381

Not Yet Recruiting

19

Local Institution - 0050

Richmond, Virginia, United States, 23284

Not Yet Recruiting

20

Local Institution - 0084

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1107

Not Yet Recruiting

21

Local Institution - 0085

La Plata, Buenos Aires, Argentina, 1900

Not Yet Recruiting

22

Local Institution - 0036

Buenos Aires, Argentina, C1405BOA

Not Yet Recruiting

23

Local Institution - 0035

Córdoba, Argentina, X5003DCE

Not Yet Recruiting

24

Local Institution - 0116

Santiago del Estero, Argentina, G4200DND

Not Yet Recruiting

25

Local Institution - 0111

Edmonton, Alberta, Canada, T6G 1Z1

Not Yet Recruiting

26

Local Institution - 0110

Kingston, Ontario, Canada, K7L4X3

Not Yet Recruiting

27

Local Institution - 0113

Toronto, Ontario, Canada, M4G 1R8

Not Yet Recruiting

28

Local Institution - 0112

Montreal, Quebec, Canada, H3T 1C5

Not Yet Recruiting

29

Local Institution - 0118

Bordeaux, France, 33076

Not Yet Recruiting

30

Local Institution - 0120

Bron, France, 69678

Not Yet Recruiting

31

Local Institution - 0119

Paris, France, 75019

Not Yet Recruiting

32

Local Institution - 0121

Gdansk, Germany, 80-546

Not Yet Recruiting

33

Local Institution - 0129

Budapest, Hungary, 1143

Not Yet Recruiting

34

Local Institution - 0130

Gyula, Hungary, 5700

Not Yet Recruiting

35

Local Institution - 0131

Szeged, Hungary, 6720

Not Yet Recruiting

36

Local Institution - 0075

Chikugo, Fukuoka, Japan, 833-0041

Not Yet Recruiting

37

Goryokai Medical Corporation - Goryokai Hospital

Sapporo, Hokkaido, Japan, 002-8029

Actively Recruiting

38

Local Institution - 0025

Zentsujichó, Kagawa-ken, Japan, 765-8507

Not Yet Recruiting

39

Local Institution - 0062

Miyakonojō, Miyazaki, Japan, 885-0093

Not Yet Recruiting

40

Local Institution - 0086

Bunkyo-ku, Tokyo, Japan, 113-8431

Not Yet Recruiting

41

Local Institution - 0056

Ōta-ku, Tokyo, Japan, 143-8541

Not Yet Recruiting

42

Local Institution - 0063

Yokohama, Kanagawa, Japan, 213-8507

Not Yet Recruiting

43

Local Institution - 0128

Poznan, Greater Poland Voivodeship, Poland, 60-744

Not Yet Recruiting

44

Local Institution - 0125

Wroclaw, Lower Silesian Voivodeship, Poland, 54-234

Not Yet Recruiting

45

Local Institution - 0122

Kraśnik, Lublin Voivodeship, Poland, 23-210

Not Yet Recruiting

46

Local Institution - 0127

Warsaw, Masovian Voivodeship, Poland, 02-957

Not Yet Recruiting

47

Local Institution - 0126

Gdansk, Pomeranian Voivodeship, Poland, 80-542

Not Yet Recruiting

48

Local Institution - 0123

Szczecin, West Pomeranian Voivodeship, Poland, 70-419

Not Yet Recruiting

49

Local Institution - 0124

Katowice, Poland, 40-146

Not Yet Recruiting

50

Local Institution - 0029

Bucharest, Bucharest, Romania, 041914

Not Yet Recruiting

51

Local Institution - 0031

Cluj-Napoca, Cluj, Romania, 400370

Not Yet Recruiting

52

Local Institution - 0040

Bucharest, Romania, 021056

Not Yet Recruiting

53

Local Institution - 0042

Bucharest, Romania, 031871

Not Yet Recruiting

54

Local Institution - 0008

Iași, Romania, 700282

Not Yet Recruiting

55

Local Institution - 0038

Timișoara, Romania, 300011

Not Yet Recruiting

56

Local Institution - 0101

Barcelona, Spain, 08036

Not Yet Recruiting

57

Local Institution - 0099

Barcelona, Spain, 8035

Not Yet Recruiting

58

Local Institution - 0098

Madrid, Spain, 28007

Not Yet Recruiting

59

Local Institution - 0100

Madrid, Spain, 28031

Not Yet Recruiting

Loading map...

Research Team

B

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

F

First line of the email MUST contain NCT # and Site #.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here