Using Microvessel Ultrasound Imaging to Study Wound Healing in Adults With Chronic Diabetic and Venous Ulcers

What this Trial Is About

This research explores the use of a high-resolution microvessel ultrasound imaging system to observe scarring and monitor wound healing in patients with chronic ulcers. The study aims to see if treatments affect the number of tiny blood vessels and circulation around the wound, focusing on chronic diabetic and venous ulcers. It is an interventional study led by the Mayo Clinic that does not involve drug phases or masking methods. Participants with chronic diabetic and venous ulcers will receive standard wound care including wound debridement and treatment. During the study, they will undergo research-specific microvessel ultrasound examinations to assess microvessel formation and tissue stiffness near the ulcer and in unaffected skin. Additionally, two skin biopsies will be taken to gather more information about the wound and skin tissue. Participants will be evaluated over a period of three months, during which microvessel imaging is the primary outcome being measured. The study includes monitoring wound healing progress through ultrasound and skin biopsy data. Patients will be assessed for blood glucose control, blood supply to the wound, and other clinical indicators to understand the healing process. Safety and wound status will be regularly checked throughout the study duration.

A Study to Evaluate Microvessel Ultrasound Imaging of Wound Healing in Patients With Chronic Ulcers