Actively Recruiting
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Led by BeOne Medicines · Updated on 2026-05-11
500
Participants Needed
149
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy and safety of BGB-16673 alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).
CONDITIONS
Official Title
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) needing treatment based on 2018 iwCLL criteria
- Previously treated for CLL or SLL with at least one line of therapy including a covalent Bruton tyrosine kinase inhibitor (cBTKi) with disease relapsed or refractory
- For participants with SLL, measurable disease by CT or MRI with at least one lymph node larger than 1.5 cm in longest diameter and measurable in two perpendicular diameters
You will not qualify if you...
- Known prolymphocytic leukemia or history or suspicion of Richter's transformation
- History of bleeding disorders such as hemophilia A, hemophilia B, von Willebrand disease, or spontaneous bleeding requiring transfusion or other medical intervention
- History of ischemic stroke or intracranial hemorrhage within 6 months before starting study drug
- Previous exposure to any Bruton tyrosine kinase (BTK) protein degraders or noncovalent BTK inhibitors (ncBTKi)
- Current or past central nervous system involvement by CLL or SLL including brain, spinal cord, leptomeninges, or cerebrospinal fluid as shown by imaging, cytology, or biopsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 149 locations
1
Mayo Clinic Phoenix
Phoenix, Arizona, United States, 85054-4502
Actively Recruiting
2
Kaiser Permanente Southern California
Irvine, California, United States, 92618-3734
Actively Recruiting
3
University of California San Diego (Ucsd) Moores Cancer Center
La Jolla, California, United States, 92093-1503
Actively Recruiting
4
Cancer and Blood Specialty Clinic
Los Alamitos, California, United States, 90720-3302
Actively Recruiting
5
UCLA Department of Medicine Hematologyoncology
Los Angeles, California, United States, 90095-3075
Actively Recruiting
6
Stanford Cancer Institute
Palo Alto, California, United States, 94304-2205
Actively Recruiting
7
Christiana Care
Newark, Delaware, United States, 19713-2055
Actively Recruiting
8
Cancer Specialists of North Florida
Jacksonville, Florida, United States, 001625
Actively Recruiting
9
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224-1865
Actively Recruiting
10
Mount Sinai Comprehensive Cancer Center
Miami, Florida, United States, 33140-2840
Actively Recruiting
11
University of Chicago Medical Center
Chicago, Illinois, United States, 60637-1443
Actively Recruiting
12
The University of Kansas Cancer Center
Westwood, Kansas, United States, 66205-2003
Actively Recruiting
13
Our Lady of the Lake Hospital
Baton Rouge, Louisiana, United States, 70808-4365
Actively Recruiting
14
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809-3738
Actively Recruiting
15
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121-2429
Actively Recruiting
16
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215-5418
Actively Recruiting
17
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201-2013
Actively Recruiting
18
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905-0001
Actively Recruiting
19
Washington University School of Medicine
St Louis, Missouri, United States, 63110-1010
Actively Recruiting
20
Titan Health Partners Llc Dba Astera Cancer Care
East Brunswick, New Jersey, United States, 08816-4096
Actively Recruiting
21
John Theurer Cancer Center Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601-2191
Actively Recruiting
22
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
23
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York, United States, 10065-6800
Actively Recruiting
24
University of Rochester
Rochester, New York, United States, 14642-0001
Actively Recruiting
25
University of North Carolina At Chapel Hill
Chapel Hill, North Carolina, United States, 27514-4220
Actively Recruiting
26
Atrium Health Levine Cancer Institute (Lci)
Charlotte, North Carolina, United States, 28204-2990
Actively Recruiting
27
Duke University Medical Center
Durham, North Carolina, United States, 27705-3976
Actively Recruiting
28
Dayton Physician Network
Dayton, Ohio, United States, 45415
Actively Recruiting
29
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111-2434
Actively Recruiting
30
Tennessee Oncology, Pllc Nashville
Nashville, Tennessee, United States, 37203
Actively Recruiting
31
Md Anderson Cancer Center
Houston, Texas, United States, 77030-3907
Actively Recruiting
32
Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia)
Roanoke, Virginia, United States, 24014
Actively Recruiting
33
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-4433
Actively Recruiting
34
Summit Cancer Centers
Spokane, Washington, United States, 99208-1129
Actively Recruiting
35
Northwest Medical Specialties
Tacoma, Washington, United States, 98405
Actively Recruiting
36
Gunderson Health System
La Crosse, Wisconsin, United States, 54601-5467
Actively Recruiting
37
Concord Repatriation General Hospital
Concord, New South Wales, Australia, NSW 2139
Actively Recruiting
38
Sunshine Coast Hospital and Health Service
Birtinya, Queensland, Australia, QLD 4575
Actively Recruiting
39
Flinders Medical Centre
Bedford PK, South Australia, Australia, SA 5042
Actively Recruiting
40
St Vincents Hospital Melbourne
Fitzroy, Victoria, Australia, VIC 3065
Actively Recruiting
41
Peninsula Private Hospital
Frankston, Victoria, Australia, VIC 3199
Actively Recruiting
42
Austin Health
Heidelberg, Victoria, Australia, VIC 3084
Actively Recruiting
43
Cabrini Hospital Malvern
Malvern East, Victoria, Australia, VIC 3144
Actively Recruiting
44
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia, VIC 3000
Actively Recruiting
45
The Alfred Hospital
Melbourne, Victoria, Australia, VIC 3004
Actively Recruiting
46
Linear Clinical Research
Nedlands, Western Australia, Australia, WA 6009
Actively Recruiting
47
Medizinische Universitatsklinik Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
48
Ordensklinikum Linz Gmbh Elisabethinen
Linz, Austria, 4020
Actively Recruiting
49
Uk St Poelten
Sankt Pölten, Austria, 3100
Actively Recruiting
50
Institut Jules Bordet
Anderlecht, Belgium, 1070
Actively Recruiting
51
UZ GENT
Ghent, Belgium, 9000
Actively Recruiting
52
Az Groeninge Campus Loofstraat
Kortrijk, Belgium, 8500
Actively Recruiting
53
Chc Montlegia
Liège, Belgium, 4000
Actively Recruiting
54
Chu de Liege
Liège, Belgium, 4000
Actively Recruiting
55
Az Sint Maarten
Mechelen, Belgium, 2800
Actively Recruiting
56
Chu Ucl Namur
Yvoir, Belgium, 5530
Actively Recruiting
57
Centro de Pesquisa Clinica Dom Bosco Ltda
Araçatuba, Brazil, 16015-150
Actively Recruiting
58
Ictr Instituto Do Cancer E Transplante de Curitiba
Curitiba, Brazil, 80510-130
Actively Recruiting
59
Hospital de Clinicas de Goiania Ufg
Goiânia, Brazil, 74605-020
Actively Recruiting
60
Inca Instituto Nacional de Cancer
Rio de Janeiro, Brazil, 20231-050
Actively Recruiting
61
Ensino E Terapia de Inovacao Clinica Amo Etica
Salvador, Brazil, 41950-640
Actively Recruiting
62
Hospital Nove de Julho Dasa
São Paulo, Brazil, 01409-001
Actively Recruiting
63
Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo
São Paulo, Brazil, 05403-010
Actively Recruiting
64
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, France, 33000
Actively Recruiting
65
Hopital Estaing
Clermontferrand, France, 63100
Actively Recruiting
66
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, France, 44000
Actively Recruiting
67
Hopital Saint Louis
Paris, France, 75010
Actively Recruiting
68
Centre Henri Becquerel
Rouen, France, 76038
Actively Recruiting
69
Iuc Toulouse Oncopole
Toulouse, France, 31100
Actively Recruiting
70
Chu Tours Hopital Bretonneau
Tours, France, 37000
Actively Recruiting
71
Chu Nancy Hopital Brabois
VandoeuvrelesNancy, France, 54511
Actively Recruiting
72
Gemeinschaftspraxis Fur Hamatologie Und Onkologie Dortmund
Dortmund, Germany, 44309
Actively Recruiting
73
Luebecker Onkologische Schwerpunktpraxis Dres Med Kisroweber
Lübeck, Germany, 23562
Actively Recruiting
74
Universitaetsklinikum Ulm
Ulm, Germany, 89081
Actively Recruiting
75
Gemeinschaftspraxis Fuer Haematologie Und Onkologie Westerstede
Westerstede, Germany, 26655
Actively Recruiting
76
Bnai Zion Medical Center
Haifa, Israel, 31048
Actively Recruiting
77
Shaare Zedek Medical Center
Jerusalem, Israel, 9103102
Actively Recruiting
78
Hadassah University Hospital Ein Kerem
Jerusalem, Israel, 91120
Actively Recruiting
79
Meir Medical Center
KfarSava, Israel, 4428164
Actively Recruiting
80
Rabin Medical Center
Petah Tikva, Israel, 49100
Actively Recruiting
81
Sheba Medical Center
Ramat Gan, Israel, 5262100
Actively Recruiting
82
Sourasky Tel Aviv Medical Center
Tel Aviv, Israel, 6423906
Actively Recruiting
83
Policlinico Sorsola Malpighi, Aou Di Bologna
Bologna, Italy, 40138
Actively Recruiting
84
Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
85
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
86
Azienda Ospedaliera Di Padova
Padova, Italy, 35128
Actively Recruiting
87
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital
Nakamuraku, Aichi-ken, Japan, 453-8511
Actively Recruiting
88
Matsuyama Red Cross Hospital
Matsuyama, Ehime, Japan, 790 8524
Actively Recruiting
89
Fukushima Medical University Hospital
Fukushima, Fukushima, Japan, 960-1295
Actively Recruiting
90
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
Hiroshima, Hiroshima, Japan, 730-8619
Actively Recruiting
91
Aiiku Hospital
Sapporo, Hokkaido, Japan, 064-0804
Actively Recruiting
92
Kochi Medical School Hospital
Nankoku, Kochi, Japan, 783-8505
Actively Recruiting
93
Japanese Red Cross Kyoto Daini Hospital
Kyotoshi, Kyoto, Japan, 602-8026
Actively Recruiting
94
Okayama University Hospital
Okayama, Okayama-ken, Japan, 700-8558
Actively Recruiting
95
Kindai University Hospital
Sakai, Osaka, Japan, 590-0197
Actively Recruiting
96
Dokkyo Medical University Saitama Medical Center
Koshigaya, Saitama, Japan, 503-8502
Actively Recruiting
97
Tokyo Metropolitan Komagome Hospital
Bunkyoku, Tokyo, Japan, 113-8677
Actively Recruiting
98
Cancer Institute Hospital of Jfcr
Kotoku, Tokyo, Japan, 135-8550
Actively Recruiting
99
National Hospital Organization (Nho) Disaster Medical Center
Tachikawashi, Tokyo, Japan, 190-0014
Actively Recruiting
100
Yamagata University Hospital
Yamagata, Yamagata, Japan, 990-9585
Actively Recruiting
101
Kumamoto University Hospital
Kumamoto, Japan, 860-8556
Actively Recruiting
102
Osaka Metropolitan University Hospital
Osaka, Japan, 545-8586
Actively Recruiting
103
Oita Prefectural Hospital
Ōita, Japan, 870-8511
Actively Recruiting
104
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands, 3318 AT
Actively Recruiting
105
Catharina Hospital
EJ Eindhoven, Netherlands, 5623
Actively Recruiting
106
Groene Hart Hospital
Gouda, Netherlands, 2803
Actively Recruiting
107
University of Medical Center Groningen (Umcg)
Groningen, Netherlands, 9713 GZ
Actively Recruiting
108
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands, 6532 SZ
Actively Recruiting
109
Universitair Medisch Centrum Utrecht
Utrecht, Netherlands, 3584 CX
Actively Recruiting
110
North Shore Hospital
Auckland, New Zealand, 0622
Actively Recruiting
111
Tauranga Hospital
Tauranga, New Zealand, 3112
Actively Recruiting
112
Wellington Regional Hospital (Ccdhb)
Wellington, New Zealand, 6021
Actively Recruiting
113
Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii
Gdansk, Poland, 80-219
Actively Recruiting
114
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach
Kielce, Poland, 25-734
Actively Recruiting
115
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
Lodz, Poland, 93-513
Actively Recruiting
116
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie Uniwersytet Medyczny W Lublinie
Lublin, Poland, 20-400
Actively Recruiting
117
Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii
Olsztyn, Poland, 10-228
Actively Recruiting
118
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
Torun, Poland, 87-100
Actively Recruiting
119
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie Hematology Unit
Warsaw, Poland, 02-781
Actively Recruiting
120
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
Wroclaw, Poland, 50-367
Actively Recruiting
121
Auxilio Mutuo Cancer Center
San Juan, Puerto Rico, 00917
Actively Recruiting
122
Coltea Clinical Hospital
Bucharest, Romania, 30171
Actively Recruiting
123
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ClujNapoca, Romania, 400015
Actively Recruiting
124
Institutul Regional de Oncologie Iasi
Iași, Romania, 700483
Actively Recruiting
125
Singapore General Hospital
Singapore, Singapore, 168582
Actively Recruiting
126
Tan Tock Seng Hospital Haematology
Singapore, Singapore, 308433
Actively Recruiting
127
Pusan National University Hospital
Seogu, Busan Gwang'yeogsi, South Korea, 49241
Actively Recruiting
128
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
129
Gyeongsang National University Hospital
Jinju, Gyeongsangnam-do, South Korea, 52727
Actively Recruiting
130
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi, South Korea, 06591
Actively Recruiting
131
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
132
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 03080
Actively Recruiting
133
Ico Badalona
Badalona, Spain, 08916
Actively Recruiting
134
Hospital Universitario de Burgos
Burgos, Spain, 09006
Actively Recruiting
135
Hospital Universitario de Gran Canaria Dr Negrin
Las Palmas de Gran Canaria, Spain, 35010
Actively Recruiting
136
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
137
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain, 28222
Actively Recruiting
138
Hospital Universitari Son Espases
Palma de Mallorca, Spain, 07120
Actively Recruiting
139
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
140
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden, 413 46
Actively Recruiting
141
Karolinska Universitetssjukhuset Solna
Stockholm, Sweden, 171 76
Actively Recruiting
142
Inselspital Bern (Inselspital, Universitatsspital Bern)
Bern, Switzerland, 3010
Actively Recruiting
143
Universitatsspital Zurich
Zurich, Switzerland, 8091
Actively Recruiting
144
University Hospitals Sussex Nhs Foundation Trust
Brighton, United Kingdom, BN2 5BE
Actively Recruiting
145
Kent and Canterbury Hospital
Canterbury, United Kingdom, CT1 3NG
Actively Recruiting
146
Hull Royal Infirmary
Hull, United Kingdom, HU3 2JZ
Actively Recruiting
147
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
148
Spire Leeds Healthcare Spire Leeds Hospital
Roundhay, United Kingdom, LS8 1NT
Actively Recruiting
149
Salisbury Foundation Trust
Salisbury, United Kingdom, SP2 8BJ
Actively Recruiting
Research Team
S
Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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